Schizophrenia Research
Volume 46, Issue 1 , Pages 45-56 , 30 November 2000

Supporting evidence for the model of cognitive dysmetria in schizophrenia — a structural magnetic resonance imaging study using deformation-based morphometry

,Accepted 7 December 1999.

References 

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. third ed.. Washington, DC: American Psychiatric Press; 1987;
  2. Andreasen NC. The Scale for the Assessment of Negative Symptoms (SANS). Iowa: The University of Iowa; 1983;
  3. Andreasen NC. The Scale for the Assessment of Positive Symptoms (SAPS). Iowa: The University of Iowa; 1984;
  4. Andreasen NC. The role of the thalamus in schizophrenia. Can. J. Psychiatry. 1997;42:27–33
  5. Andreasen NC, Nasrallah HA, Dunn V, Olson SC, Grove WM, Ehrhardt JC, et al. Structural abnormalities in the frontal system in schizophrenia. Arch. Gen. Psychiatry. 1986;43:136–144
  6. Andreasen NC, Ehrhardt JC, Swayze VW, Alliger RJ, Yuh WT, Cohen G, et al. Magnetic resonance imaging of the brain in schizophrenia: the pathophysiological significance of structural abnormalities. Arch. Gen. Psychiatry. 1990;47:35–44
  7. Andreasen NC, Cizadlo T, Harris G, Swayze V, O'Leary DS, Cohen G, et al. Voxel processing techniques for the antemortem study of neuroanatomy and neuropathology using magnetic resonance imaging. J. Neuropsychiatry Clin. Neurosci. 1993;5:121–130
  8. Andreasen NC, Arndt S, Swayze V, Cizadlo T, Flaum M, O'Leary D, et al. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image avaraging. Science. 1994;266:294–298
  9. Andreasen NC, O'Leary DS, Cizadlo T, Arndt S, Rezai K, Ponto LL, et al. Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal–thalamic–cerebellar circuitry. Proc. Natl. Acad. Sci. USA. 1996;93:9985–9990
  10. Andreasen NC, Paradiso S, O'Leary DS. “Cognitive dysmetria” as an integrative theory of schizophrenia: a dysfunction in cortical–subcortical–cerebellar circuitry?. Schiz. Bull. 1998;24:203–218
  11. Ashburner J, Friston K. Nonlinear spatial normalization using basis functions. Hum. Brain Mapp. 1999;7:254–266
  12. Aylward EH, Reiss A, Barta PE, Tien A, Han W, Lee J, et al. Magnetic resonance imaging measurement of posterior fossa structures in schizophrenics. Am. J. Psychiatry. 1994;151:1448–1452
  13. Barta PE, Pearlson GD, Powers RE, Menon R, Richards S, Tune LE. Temporal lobe in schizophrenia. (abstract) APA New Res. Abstr. 1992;1992:146
  14. Benes FM, Paskevich P, Davidson J, Domesick VB. The effects of haloperidol on synaptic patterns in rat striatum. Brain Res. 1985;329:265–274
  15. Buchanan RW, Vlader K, Barta PE, Pearlson GD. Structural evaluation of the prefrontal cortex in schizophrenia. Am. J. Psychiatry. 1998;155:1049–1055
  16. Buchsbaum MS, Haier RJ, Potkin SG, Nuechterlein K, Bracha HS, Katz M, et al. Frontostriatal disorder of cerebral metabolism in never medicated schizophrenics. Arch. Gen. Psychiatry. 1992;49:935–942
  17. Buchsbaum MS, Someya T, Teng CY, Abel L, Chin S, Najafi A, et al. PET and MRI of the thalamus in never-medicated patients with schizophrenia. Am. J. Psychiatry. 1996;153:191–199
  18. Chakos MH, Lieberman JA, Bilder RM, Borenstein M, Lerner G, Bogerts B, et al. Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs. Am. J. Psychiatry. 1994;151:1430–1436
  19. Chua SE, McKenna PJ. Schizophrenia — a brain disease? A critical review of structural and functional cerebral abnormality in the disorder. Br. J. Psychiatry. 1995;166:563–582
  20. Coffman JA, Schwarzkopf SB, Olson SC, Nasrallah HA. Midsagittal cerebral anatomy by magnetic resonance imaging. The importance of slice position and thickness. Schizophr. Res. 1989;2:287–294
  21. Courchesne E, Press GA, Murakami JA, Berthoty D, Grafe M, Wiley CA, et al. The cerebellum in sagittal plane — anatomic-MR correlation: 1. The vermis. AJR Am. J. Roentgenol. 1989;10:829–835
  22. Davatzikos C, Vaillant M, Resnick SM, Prince JL, Letovsky S, Bryan RN. A computerized approach for morphological analysis of the corpus callosum. J. Comput. Assist. Tomogr. 1996;20:88–97
  23. DeLisi LE, Hoff AL, Neale C, Kushner M. Asymmetries in the superior temporal lobe in male and female first-episode schizophrenic patients: measures of the planum temporale and superior temporal gyrus by MRI. Schizophr. Res. 1994;12:19–28
  24. DeLisi LE, Sakuma M, Tew W, Kushner M, Hoff AL, Grimson R. Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia. Psychiatry Res. Neuroimaging. 1997;74:129–140
  25. De Quardo JR, Bookstein FC, Green WDK, Brunberg JA, Tandon R. Spatial relationship of neuroanatomic landmarks in schizophrenia. Psychiatry Res. Neuroimaging. 1996;67:81–95
  26. Deshmukh A, Sullivan EV, Mathalon DH, Desmond JE, Matsumoto B, Lim KO, et al. Cerebellar volume deficits in schizophrenia. (abstract) Biol. Psychiatry. 1996;39:600
  27. Elkashef AM, Buchanan RW, Gellad F, Munson RC, Breier A. Basal ganglia pathology in schizophrenia and tardive dyskenisia: an MRI quantitative study. Am. J. Psychiatry. 1994;151:752–755
  28. Feinberg I. Schizophrenia and late maturational brain changes in man. Psychopharmacol. Bull. 1982;18:29–31
  29. Flaum M, Swayze VW, O'Leary DS, Yuh WT, Ehrhardt JC, Arndt SV, et al. Effects of diagnosis, laterality and gender on brain morphology in schizophrenia. Am. J. Psychiatry. 1995;152:704–714
  30. Frazier JA, Giedd JN, Kaysen D, Albus K, Hamburger S, Alaghband-Rad J, et al. Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment. Am. J. Psychiatry. 1996;153:564–566
  31. Friston KJ, Ashburner J, Frith CD, Poline JB, Heather JD, Frackowiak RSJ. Spatial registration and normalization of images. Hum. Brain Mapp. 1995;2:165–189
  32. Frith CD, Friston KJ, Herold S, Silbersweig D, Fletcher P, Cahill C, et al. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br. J. Psychiatry. 1995;167:343–349
  33. Gaser C, Volz HP, Kiebel S, Riehemann S, Sauer H. Detecting structural changes in whole brain based on nonlinear deformation — application to schizophrenia research. Neuroimage. 1999;10:107–113
  34. Graybiel AM. Neurotansmitters and neuromodulators in the basal ganglia. Trends Neurosci. 1990;13:244–254
  35. Gurtin ME. An Introduction to Continuum Mechanics. New York: Academic Press; 1987;
  36. Hajek M, Huonker R, Boehle C, Volz HP, Nowak H, Sauer H. Abnormalities of auditory evoked magnetic fields and structural changes in the left hemisphere of male schizophrenics — a magnetoencephalographic–magnetic resonance imaging study. Biol. Psychiatry. 1997;42:609–616
  37. Haller JW, Banerjee A, Christensen GE, Gado M, Joshi S, Miller MI, et al. Three-dimensional hippocampal MR morphometry with high-dimensional transformation of a neuroanatomic atlas. Radiology. 1997;202:504–510
  38. Hokama H, Shenton ME, Nestor PG, Kikinis R, Levitt JJ, Metcalf D, et al. Caudate, putamen and globus pallidus volume in schizophrenia: a quantitative MRI study. Psychiatry Res. Neuroimaging. 1995;61:209–229
  39. Iosifescu DV, Shenton ME, Warfield SK, Kikinis R, Dengler J, Jolesz FA, et al. An automated registration algorithm for measuring MRI subcortical brain structures. Neuroimage. 1997;6:13–15
  40. Jacobsen LK, Giedd JN, Berquin PC, Krain AL, Hamburger SD, Kumra S, et al. Quantitative morphology of the cerebellum and fourth ventricle in childhood-onset schizophrenia. Am. J. Psychiatry. 1997;154:1663–1669
  41. Jacobsen LK, Hamburger SD, van Horn JD, Vaituzis AC, McKenna K, Frazier JA, et al. Cerebral glucose metabolism in childhood onset schizophrenia. Psychiatry Res. 1997;75:131–144
  42. Jernigan TL, Zisook S, Heaton RK, Moranville JT, Hesselink JR, Braff DL. Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. Arch. Gen. Psychiatry. 1991;48:881–890
  43. Kelsoe JR, Cadet JL, Picar JL, Weinberger DR. Quantitative neuroanatomy in schizophrenia: a controlled magnetic resonance imaging study. Arch. Gen. Psychiatry. 1988;45:533–541
  44. Kulynich JJ, Vladar K, Jones DW, Weinberger DR. Superior temporal gyrus volume in schizophrenia: a study using MRI morphometry assisted by surface rendering. Am. J. Psychiatry. 1996;153:50–56
  45. Lawrie SM, Abukmeil SS. Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. Br. J. Psychiatry. 1998;172:110–120
  46. Leiner HC, Leiner AL, Dow RS. The underestimated cerebellum. Hum. Brain Mapp. 1995;2:244–254
  47. Lewitt JJ, Donnino R, Shenton ME, Kikinis R, Jolesz FA, McCarley RW. A quantitative volumetric MRI study of the brainstem and cerebellum in schizophrenia. (abstract) Biol. Psychiatry. 1996;39:639
  48. Mathew RJ, Partain L. Midsagittal sections of the cerebellar vermis and fourth ventricle obtained with magnetic resonance imaging of schizophrenic patients. Am. J. Psychiatry. 1985;142:970–971
  49. Menon RR, Barta PE, Aylward EH, Richards SS, Vaughn DD, Tien AY. Posterior superior temporal gyrus in schizophrenia: grey matter changes and clinical correlates. Schizophr. Res. 1995;16:127–135
  50. Mion CC, Andreasen NC, Arndt S, Swayze VW, Cohen GA. MRI abnormalities in tardive dyskinesia. Psychiatry Res. 1991;40:157–166
  51. Nasrallah HA, Schwarzkopf SB, Olson SC, Coffman JA. Perinatal brain injury and cerebral vermal lobules I–X in schizophrenia. Biol. Psychiatry. 1991;29:567–574
  52. Nelson MD, Saykin AJ, Flashman LA, Riordan HJ. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging. A meta-analytic study. Arch. Gen. Psychiatry. 1998;55:433–440
  53. Overall JE, Gorham DR. The brief psychiatric rating scale. Psychol. Rep. 1962;10:799–812
  54. Paus T, Tomaiuolo F, Otaky N, MacDonald D, Petrides M, Atlas J, et al. Human cingulate and paracingulate sulci: pattern, variability, asymmetry, and probabilistic map. Cereb. Cortex. 1996;6:207–214
  55. Penhune VB, Zatorre RJ, MacDonald JD, Evans AC. Interhemispheric anatomical differences in human primary auditory cortex: probabilistic mapping and volume measurement from magnetic resonance scans. Cereb. Cortex. 1996;6:661–672
  56. Portas CM, Goldstein JM, Shenton ME, Hokama HH, Wible CG, Fischer I. Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biol. Psychiatry. 1998;43:649–659
  57. Raine A, Lencz T, Reynolds GP, Harrison G, Sheard C, Medley I, et al. An evaluation of structural and functional prefrontal deficits in schizophrenia. MRI and neuropsychological measures. Psychiatry Res. 1992;45:123–137
  58. Raz S, Raz N. Structural brain abnormalities in the major psychoses: a quantitative review of the evidence from computerized imaging. Psychol. Bull. 1990;108:93–108
  59. Rossi A, Stratta P, Mancini F, de Cataldo S, Casacchia M. Cerebellar vermal size in schizophrenia: a male effect. Biol. Psychiatry. 1993;33:354–357
  60. Schlaepfer TE, Harris GJ, Tien AY, Peng LW, Lee S, Federman EB. Decreased regional cortical gray matter volume in schizophrenia. Am. J. Psychiatry. 1994;151:842–848
  61. Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N. Engl. J. Med. 1992;327:604–612
  62. Silbersweig DA, Stern E. Functional neuroimaging of hallucinations in schizophrenia: toward an integration of bottom-up and top-down approaches. Mol. Psychiatry. 1996;1:367–375
  63. Smith RC, Baumgartner R, Calderon M. Magnetic resonance imaging of brains of schizophrenic patients. Psychiatry Res. 1987;20:33–46
  64. Stevens JR. Abnormal reinervation as a basis for schizophrenia: a hypothesis. Arch. Gen. Psychiatry. 1992;49:238–243correction: Arch. Gen. Psychiatry. 1992;49:708
  65. Stratta P, Rossi A, Gallucci M, Amicarelli I, Passariello R, Casacchia M. Hemispheric asymmetries and schizophrenia: a preliminary magnetic resonance imaging study. Biol. Psychiatry. 1989;25:275–284
  66. Suddath RL, Cassanova MF, Goldberg TE, Daniel DG, Kelsoe JR, Weinberger DR. Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. Am. J. Psychiatry. 1989;146:464–472
  67. Swayze VW, Andreasen NC, Alliger RJ, Yuh WTC, Ehrhardt JC. Subcortical and temporal structures in affective disorders and schizophrenia: a magnetic resonance imaging study. Biol. Psychiatry. 1992;31:221–240
  68. Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain. Stuttgart: Thieme; 1988;
  69. Thirion, J.P., Calmon, G., 1997. Deformation analysis to detect and quantify active lesions in 3D. Medical Image Sequences. Inria, Technical Report 3101.
  70. Thompson PM, MacDonald D, Mega MS, Holmes CJ, Evans AC, Toga AW. Detection and mapping of abnormal brain structure with a probabilistic atlas of cortical surfaces. J. Comput. Assist. Tomogr. 1997;21:67–81
  71. Vita A, Dieci M, Giobbio GM, Caputo A, Ghiringhelli L, Comazzi M, et al. Language and thought disorder in schizophrenia: brain morphological correlates. Schizophr. Res. 1995;15:243–251
  72. Volkow ND, Levy A, Brodie JD, Wolf AP, Cancro R, van Gelder P, et al. Low cerebellar metabolism in medicated patients with schizophrenia. Am. J. Psychiatry. 1992;149:686–688
  73. Ward KE, Friedman L, Wise A, Schulz SC. Meta-analysis of brain and cranial size in schizophrenia. Schizophr. Res. 1996;22:197–213
  74. Wible CG, Shenton ME, Fischer IA, Allard JE, Kikinis R, Jolesz FA, et al. Parcellation of the human prefrontal cortex using MRI. Psychiatry Res. 1997;28:29–40
  75. Williamson P, Pelz D, Merskey H, Morrison C, Conlon P. Correlation of negative symptoms in schizophrenia with frontal lobe parameters on magnetic resonance imaging. Br. J. Psychiatry. 1991;159:130–134
  76. Wolkin A, Rusinek H, Vaid G, Arena L, Lafargue T, Sanfilipo M. Structural magnetic resonance image averaging in schizophrenia. Am. J. Psychiatry. 1998;8:1064–1073
  77. Young AH, Blackwood DHR, Roxborough H. A magnetic resonance imaging study of schizophrenia: brain structure and clinical symptoms. Br. J. Psychiatry. 1991;158:158–164
  78. Zipursky RB, Lim DO, Sullivan EV, Brown BW, Pfefferbaum A. Widespread cerebral gray matter volume deficits in schizophrenia. Arch. Gen. Psychiatry. 1992;49:195–205
  79. Zipursky RM, Marsh L, Lim KO, DeMent S, Shear PK, Sullivan EV. Volumetric MRI assessment of the temporal lobe structures in schizophrenia. Biol. Psychiatry. 1994;35:501–506

PII: S0920-9964(99)00236-4

Schizophrenia Research
Volume 46, Issue 1 , Pages 45-56 , 30 November 2000

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