Schizophrenia Research
Volume 42, Issue 1 , Pages 29-39 , 16 March 2000

Regional cerebral blood flow in male schizophrenic patients performing an auditory discrimination task

  • Masato Higashima

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Kanazawa University, Kanazawa 920-8641, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-76-265-2304; fax: +81-76-234-4254
    • ,
  • Yasuhiro Kawasaki

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Kanazawa University, Kanazawa 920-8641, Japan
    • ,
  • Katsumi Urata

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Kanazawa University, Kanazawa 920-8641, Japan
    • ,
  • Naoto Sakai

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Kanazawa University, Kanazawa 920-8641, Japan
    • ,
  • Tatsuya Nagasawa

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Kanazawa University, Kanazawa 920-8641, Japan
    • ,
  • Yoshifumi Koshino

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Kanazawa University, Kanazawa 920-8641, Japan
    • ,
  • Hisashi Sumiya

      Affiliations

    • Department of Nuclear Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
    • ,
  • Norihisa Tonami

      Affiliations

    • Department of Nuclear Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
    • ,
  • Shiro Tsuji

      Affiliations

    • Department of Radiological Technology, School of Health Sciences, Kanazawa University, Kanazawa, Japan
    • ,
  • Hiroshi Matsuda

      Affiliations

    • Division of Radiology and Nuclear Medicine, National Center Hospital for Mental, Nervous and Muscular Disorders, NCNP, Tokyo, Japan

Received 14 January 1999 ,Accepted 20 May 1999.

References 

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed., revised. Washington, DC: American Psychiatric Press; 1987;
  2. Andersen AR. 99mTc-d,l-hexamethylene-propyleneamine oxime (99mTc-HMPAO): basic kinetic studies of a tracer of cerebral blood flow. Cerebrovasc. Brain Metab. Rev. 1989;1:288–318
  3. Andreasen NC, Grove W. The relationship between schizophrenic language, manic language, and aphasia. In:  Gruzelier J,  Flor-Henry P editor. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier/North Holland; 1979;p. 373–390
  4. Andreasen NC, Rezai K, Alliger R, Swayze II VW, Flaum M, Kirchner P, et al. Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia: assessment with xenon 133 single-photon emission computed tomography and the Tower of London. Arch. Gen. Psychiatry. 1992;49:943–958
  5. Andreasen NC, O'Leary DS, Flaum M, Nopoulos P, Watkins GL, Ponto LLB, et al. Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naı̈ve patients. Lancet. 1997;349:1730–1734
  6. Berman KF, Torrey EF, Daniel DG, Weinberger DR. Regional cerebral blood flow in monozygotic twins discordant and concordant for schizophrenia. Arch. Gen. Psychiatry. 1992;49:927–934
  7. Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophr. Bull. 1993;19:233–259
  8. Buchsbaum MS, DeLisi LE, Holcomb HH, Cappelletti J, King AC, Johnson J, et al. Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch. Gen. Psychiatry. 1984;41:1159–1166
  9. Buchsbaum MS, Nuechterlein KH, Haier RJ, Wu J, Sicotte N, Hazlett E, et al. Glucose metabolic rate in normals and schizophrenics during the continuous performance test assessed by positron emission tomography. Br. J. Psychiatry. 1990;156:216–227
  10. Buchsbaum MS, Haier RJ, Potkin SG, Nuechterlein K, Bracha HS, Katz M, et al. Frontostriatal disorder of cerebral metabolism in never-medicated schizophrenics. Arch. Gen. Psychiatry. 1992;49:935–942
  11. Chao LL, Knight RT. Human prefrontal lesions increase distractibility to irrelevant sensory inputs. NeuroReport. 1995;6:1605–1610
  12. Cleghorn JM, Garnett ES, Nahmias C, Firnau G, Brown GM, Kaplan R, et al. Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia. Psychiatry Res. 1989;28:119–133
  13. Cohen RM, Semple WE, Gross M, Nordahl TE, DeLisi LE, Holcomb HH, et al. Dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sci. 1987;40:2031–2039
  14. Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N, et al. Schizophrenia as an anomaly of development of cerebral asymmetry: a postmortem study and a proposal concerning the genetic basis of the disease. Arch. Gen. Psychiatry. 1989;46:1145–1150
  15. DeLisi LE, Holcomb HH, Cohen RM, Pickar D, Carpenter W, Morihisa JM, et al. Positron emission tomography in schizophrenic patients with and without neuroleptic medication. J. Cereb. Blood Flow Metab. 1985;5:201–206
  16. Erbas B, Kumbasar H, Erbengi G, Bekdik C. Tc-99m HMPAO/SPECT determination of regional cerebral blood flow changes in schizophrenics. Clin. Nucl. Med. 1990;15:904–907
  17. Flor-Henry P. Psychosis and temporal lobe epilepsy: a controlled investigation. Epilepsia. 1969;10:363–395
  18. Ford JM, Pfefferbaum A, Roth W. P3 and schizophrenia. Ann. NY Acad. Sci. 1992;658:146–162
  19. Franzén G, Ingvar DH. Absence of activation in frontal structures during psychological testing of chronic schizophrenics. J. Neurol. Neurosurg. Psychiatry. 1975;38:1027–1032
  20. Fuster JM. The Prefrontal Cortex: Anatomy, Physiology and Neuropsychology of the Frontal Lobe. 3rd ed.. Philadelphia: Lippincott-Raven; 1997;
  21. Geraud G, Arné-Bès MC, Güell A, Bes A. Reversibility of hemodynamic hypofrontality in schizophrenia. J. Cereb. Blood Flow Metab. 1987;7:9–12
  22. Gur RE, Skolnick BE, Gur RC, Caroff S, Rieger W, Obrist WD, et al. Brain function in psychiatric disorders: I. Regional cerebral blood flow in medicated schizophrenics. Arch. Gen. Psychiatry. 1983;40:1250–1254
  23. Higashima M, Kawasaki Y, Urata K, Maeda Y, Sakai N, Mizukoshi C, et al. Simultaneous observation of regional cerebral blood flow and event-related potential during performance of an auditory task. Cogn. Brain Res. 1996;4:289–296
  24. Higashima M, Urata K, Kawasaki Y, Maeda Y, Sakai N, Mizukoshi C, et al. P300 and the thought disorder factor extracted by factor-analytic procedures in schizophrenia. Biol. Psychiatry. 1998;44:115–120
  25. Holcomb HH, Cascella NG, Medoff DR, Gastineau EA, Loats H, Thaker GK, et al. PET-FDG test–rest reliability during a visual discrimination task in schizophrenia. J. Comput. Assist. Tomogr. 1993;17:704–709
  26. Holcomb HH, Cascella NG, Thaker GK, Medoff DR, Dannals RF, Tamminga CA. Functional sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol. Am. J. Psychiatry. 1996;153:41–49
  27. Ingvar DH, Franzén G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr. Scand. 1974;50:425–462
  28. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 1987;13:261–276
  29. Knight RT, Scabini D, Woods DL. Prefrontal cortex gating of auditory transmission in humans. Brain Res. 1989;504:338–342
  30. Kurachi M, Kobayashi K, Matsubara R, Hiramatsu H, Yamaguchi N, Matsuda H, et al. Regional cerebral blood flow in schizophrenic disorders. Eur. Neurol. 1985;24:176–181
  31. Lassen NA, Andersen AR, Friberg L, Paulson OB. The retention of [99mTc]-d,l,-HM-PAO in the human brain after intracarotid bolus injection: a kinetic analysis. J. Cereb. Blood Flow Metab. 1988;8(Suppl.):13–22
  32. Lohr JB, Caligiuri MP. Lateralized hemispheric dysfunction in the major psychotic disorders: historical perspectives and findings from a study of motor asymmetry in older patients. Schizophr. Res. 1997;27:191–198
  33. Matsuda H, Tsuji S, Shuke N, Sumiya H, Tonami N, Hisada K. A quantitative approach to technetium-99m hexamethylpropylene amine oxime. Eur. J. Nucl. Med. 1992;19:195–200
  34. Matsuda H, Tsuji S, Shuke N, Sumiya H, Tonami N, Hisada K. Noninvasive measurements of regional cerebral blood flow using technetium-99m hexamethylpropylene amine oxime. Eur. J. Nucl. Med. 1993;20:391–401
  35. Mazziotta JC, Phelps ME, Carson RE, Kuhl DE. Tomographic mapping of human cerebral metabolism: sensory deprivation. Ann. Neurol. 1982;12:435–444
  36. Molnár M. On the origin of the P3 event-related potential component. Int. J. Psychophysiol. 1994;17:129–144
  37. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J. Cereb. Blood Flow Metab. 1983;3:1–7
  38. Pfefferbaum A, Ford JM, White RM, Roth WT. P3 in schizophrenia is affected by stimulus modality, response requirements, medication status, and negative symptoms. Arch. Gen. Psychiatry. 1989;46:1035–1044
  39. Posner MI. Psychobiology of attention. In:  Gazzaniga MS,  Blakemore C editor. Handbook of Psychobiology. New York: Academic Press; 1975;p. 441–480
  40. Prohovnik I, Håkansson K, Risberg J. Observations on the functional significance of regional cerebral flow in ‘resting’ normal subjects. Neuropsychologia. 1980;18:203–217
  41. Reveley MA, Reveley AM, Baldy R. Left hemisphere hypodensity in discordant schizophrenic twins: a controlled study. Arch. Gen. Psychiatry. 1987;44:625–632
  42. Rubin P, Holm S, Friberg L, Videbech P, Andersen HS, Bendsen BB, et al. Altered modulation of prefrontal and subcortical brain activity in newly diagnosed schizophrenia and schizophreniform disorder: a regional cerebral blood flow study. Arch. Gen. Psychiatry. 1991;48:987–995
  43. Swanson CL, Mozley JMH, Gur RE. Positron emission tomography studies of cerebral metabolism and blood flow in schizophrenia. In:  Krishnan KRR,  Doraiswamy PM editor. Brain Imaging in Clinical Psychiatry. New York: Marcel Dekker; 1997;p. 401–424
  44. Szechtman H, Nahmias C, Garnett ES, Firnau G, Brown GM, Kaplan RD, et al. Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Arch. Gen. Psychiatry. 1988;45:523–532
  45. Volkow ND, Brodie JD, Wolf AP, Angrist B, Russel J, Cancro R. Brain metabolism in patients with schizophrenia before and after acute neuroleptic administration. J. Neurol. Neurosurg. Psychiatry. 1986;49:1199–1202
  46. Wolkin A, Jaeger J, Brodie JD, Wolf AP, Fowler J, Rotrosen J, et al. Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. Am. J. Psychiatry. 1985;142:564–571
  47. Wolkin A, Sanfilipo M, Wolf AP, Angrist B, Brodie JD, Rotrosen J. Negative symptoms and hypofrontality in chronic schizophrenia. Arch. Gen. Psychiatry. 1992;49:959–965

PII: S0920-9964(99)00094-8

Schizophrenia Research
Volume 42, Issue 1 , Pages 29-39 , 16 March 2000

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