Schizophrenia Research
Volume 43, Issue 2 , Pages 159-166 , 16 June 2000

Striatal D2 dopamine receptor density and psychotic symptoms in schizophrenia: a longitudinal study

  • E.K.G Syvälahti

      Affiliations

    • Department of Pharmacology and Clinical Pharmacology, University of Turku, Kiinamyllynkatu 10, FIN 20520, Turku, Finland
    • Turku Cyclotron/PET-Center, FIN-20520, Turku, Finland
    • Corresponding Author InformationCorresponding author. Tel.: +358-2-333-7582; fax: +358-2-333-7216
    • ,
  • V Räkköläinen

      Affiliations

    • Psychiatric Clinic, Turku City Hospital, Turku, Finland
    • ,
  • J Aaltonen

      Affiliations

    • Psychiatric Clinic, Turku City Hospital, Turku, Finland
    • ,
  • V Lehtinen

      Affiliations

    • Psychiatric Clinic, Turku City Hospital, Turku, Finland
    • ,
  • J Hietala

      Affiliations

    • Turku Cyclotron/PET-Center, FIN-20520, Turku, Finland
    • Psychiatric Clinic, Turku University Central Hospital, Turku, Finland

References 

  1. Breier A, Su TP, Saunders R, Carson RE, Kolachana BS, de-Bartolomeis A, et al. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc. Natl. Acad. Sci. USA. 1997;94:2569–2574
  2. Farde L, Wiesel F, Stone-Elander S, Halldin C, Nordström A, Hall H, et al. D2 dopamine receptors in neuroleptic-naive schizophrenic patients. Arch. Gen. Psychiatry. 1990;47:213–219
  3. Farde L, Nordström A, Karlsson P, Halldin C, Sedvall G. Positron emission tomography studies on dopamine receptors in schizophrenia. Clin. Neuropharmacol. 1995;18(suppl. 1):121–129
  4. Hietala J, Syvälahti E, Vuorio K, Någren K, Lehikoinen P, Ruotsalainen U, et al. Striatal dopamine D2 receptor characteristics in neuroleptic-naive schizophrenic patients studied with positron emission tomography. Arch. Gen. Psychiatry. 1994;51:116–123
  5. Hietala J, Syvälahti E, Vuorio K, Räkköläinen V, Bergman J, Haaparanta M, et al. Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients. Lancet. 1995;346:1130–1131
  6. Hietala J, Någren K, Lehikoinen P, Ruotsalainen U, Syvälahti E. Measurement of striatal D2 dopamine density and affinity with (11C)-raclopride in vivo. A test–retest analysis. J. Cereb. Blood Flow Metab. 1999;19:210–217
  7. Hietala J, Syvälahti E, Vilkman H, Vuorio K, Räkköläinen V, Bergman J, et al. Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizopheria. Schizophr. Res. 1999;35:41–50
  8. Laruelle M, Abi-Dhargam A, van Dyck C, Gil RD, D'Souza C, Erdos J, et al. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc. Natl. Acad. Sci. USA. 1996;93:9235–9240
  9. Nordström A, Farde L, Eriksson L, Halldin C. No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone. Psych. Res.: Neuroimaging. 1995;61:67–83
  10. Pearlson G, Wong D, Tune L, Ross C, Chase G, Links J, et al. In vivo D2 dopamine receptor density in psychotic and nonpsychotic patients with bipolar disorder. Arch. Gen. Psychiatry. 1995;52:471–477
  11. Tune L, Wong D, Pearlson G, Strauss M, Young T, Shaya E, et al. Dopamine D2 receptor density estimates in schizophrenia: a positron emission tomography study with 11C-N-methylspiperone. Psych. Res. 1993;49:219–237
  12. Wong D, Wagner H, Tune L, Dannals R, Pearlson G, Links J, et al. Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science. 1986;234:1558–1563

PII: S0920-9964(99)00027-4

Schizophrenia Research
Volume 43, Issue 2 , Pages 159-166 , 16 June 2000

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