Elsevier

Schizophrenia Research

Volume 195, May 2018, Pages 406-408
Schizophrenia Research

Letter to the Editor
First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction

https://doi.org/10.1016/j.schres.2017.09.016Get rights and content

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Contributors

Lilly Schwieler, Sophie Erhardt, Göran Engberg designed the study. Funda Orhan, Sophie Erhardt, and Göran Engberg drafted the report. Lilly Schwieler and Funda Orhan performed the cytokine analysis. Helena Fatouros-Bergman was responsible for all cognitive test sessions. Simon Cervenka and Lena Flyckt were responsible for clinical data. Carl Sellgren and Funda Orhan were responsible for the statistical analyses. All authors contributed to the interpretation of the results, provided critical

Role of funding source

There are no commercial associations that might pose a conflict of interest in connection with the manuscript. No funding sources had any role in the study design, in the collection, analysis, and interpretation of data, in the writing of the report, or in the decision to submit the paper for publication. This work was supported by grants from Psykiatrifonden, the Swedish Medical Research Council (SE: 2009-7053; 2013-2838; SC: 523-2014-3467), the Swedish Brain Foundation, Åhlén-siftelsen, Märta

Collaborators

Members of the Karolinska Schizophrenia Project (KaSP): Göran Engberg; Sophie Erhardt; Lilly Schwieler; Funda Orhan; Anna Malmqvist; Mikael Hedberg (Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden); Lars Farde; Helena Fatouros-Bergman; Simon Cervenka; Lena Flyckt; Karin Collste; Pauliina Victorsson (Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden); Fredrik Piehl (Department of Clinical Neuroscience,

Conflict of interest

The authors have no financial conflicts of interest.

Acknowledgments

We thank all the patients and healthy volunteers for their willingness to participate in the study. We also wish to express our appreciation to the research nurses Minna Juntura, Henrik Gregemark, Joachim Eckerström, Marie Adolfsson and Martin Szabo for their excellent work in recruiting and taking care of patients and healthy volunteers, as well as for their handling and maintenance of the clinical data base. The helpfulness of the staff at the participating psychiatric units in Stockholm

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References (7)

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  • Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms

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    Serum cortisol and depressive symptoms independently contributed to the explained variance in IL-18/IL-18BP ratio, suggesting that stress, depressive symptoms and IL-18-pathway activation may interact in adolescents with EOP. Our findings in adolescents with EOP support findings in adults with psychosis that showed elevated IL-18 levels (Orhan et al., 2018; Tanaka et al., 2000; Wu et al., 2016; Xiu et al., 2012) and an imbalance in the IL-18/IL-18BP ratio among younger adult patients (Palladino et al., 2012). An increased IL-18/IL-18BP ratio may induce a pro inflammatory state because elevated levels of free IL-18 stimulate nuclear factor-κB-dependent transcription of inflammatory cytokines, chemokines, adhesion molecules and inflammatory enzymes (Barnes and Karin, 1997).

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Karolinska Schizophrenia Project (KaSP) consortium – Members of Karolinska Schizophrenia Project (KaSP) are listed at the end of the article as collaborators.

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