Elsevier

Schizophrenia Research

Volume 195, May 2018, Pages 579-580
Schizophrenia Research

Letter to the Editor
Exploration of clinical high-risk dropouts

https://doi.org/10.1016/j.schres.2017.09.018Get rights and content

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Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Contributors

Drs. Addington, Cadenhead, Cannon, Cornblatt, McGlashan, Perkins, Seidman, Tsuang, Walker, Woods, Bearden, and Mathalon, were responsible for the design of the study and for the supervision of all aspects of data collection. Ms. Stowkowy drafted the manuscript, and with Ms. Liu was responsible for data analysis. All authors contributed to and approved the final manuscript.

Role of funding source

The NIMH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

Acknowledgements

This study was supported by the National Institute of Mental Health (grant U01MH081984 to Dr. Addington; grants U01 MH081928; P50 MH080272; Commonwealth of Massachusetts SCDMH82101008006 to Dr. Seidman; grants R01 MH60720, U01 MH082022 and K24 MH76191 to Dr. Cadenhead; grant U01MH081902 to Dr. Cannon; grant U01MH082004-01A1 to Dr. Perkins; grant U01MH081988 to Dr. Walker; grant U01MH082022 to Dr. Woods; and UO1 MH081857-05 grant to Dr. Cornblatt.

References (5)

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    All participants were assessed with the Structured Interview for Psychosis-risk Syndromes (SIPS) (McGlashan et al., 2010) to determine if they met Criteria for Psychosis-risk Syndromes (COPS) [i.e., one or more of the following high risk syndromes: attenuated psychotic symptoms syndrome (APSS); brief intermittent psychotic symptoms syndrome (BIPS); or genetic risk and deterioration syndrome (GRD)]. Of the total 764 NAPLS-2 participants, 86 made the transition to psychosis, 390 did not complete the 2-year study (Stowkowy et al., 2018), 21 were retained for 2 years but were excluded because they had significant missing data at 24 months (n = 10) or they met GRD criteria only (n = 11). Thus, the sample described in this paper includes 268 participants who had not made the transition to psychosis and had completed 2 years of follow-up and 86 participants who transitioned to psychosis.

  • Depression: An actionable outcome for those at clinical high-risk

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    From this NAPLS-2 sample of 764, there were 86 who had transitioned to psychosis, 390 dropped out before two years for various reasons and 21 who did complete two years were excluded from the analyses as they were missing the depression assessments. We have previously demonstrated that there were no clinical differences between those who completed the study and those who dropped out prior to two years (Stowkowy et al., 2018). We have also previously reported that there was minimal depression (less than 4%) reported over time in the healthy control group that was part of NAPLS-2 (Addington et al., 2012; Addington et al., 2017).

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