Central serotonergic function in patients with predominantly negative symptoms of schizophrenia
Section snippets
Conflict of interest
No conflicts of interests have to be declared.
Contributors
I. Uhl, P. Roser, C. Norra and G. Juckel designed and performed the study. I. Uhl and G. Juckel wrote the first draft. A. Kulik, A. Theodoridou, C. Wyss, M. Brüne and W. Kawohl contributed to recruitment of patients, performing data analyses and discussion of the data. All authors have approved the final version.
Acknowledgement
No conflicts of interests have to be declared.
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The loudness dependence of auditory evoked potentials as an electrophysiological marker of central serotonergic neurotransmission: implications for clinical psychiatry and psychopharmacotherapy
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :These results might suggest a decreased central serotonergic activity in patients with predominant negative symptoms. However, a subsequent study with a larger sample size revealed a strong opposite result (Uhl et al., 2018). In this study, predominant negative symptoms in patients with schizophrenia were associated with reduced LDAEP values, indicating an enhanced serotonergic neurotransmission.
Neural noise and cortical inhibition in schizophrenia
2020, Brain StimulationCitation Excerpt :This was interpreted in the context of a close relationship between GABA and serotonergic activity [60]. Furthermore, the serotonergic system has been reported to be involved in persons with prominent negative symptoms in schizophrenia [61,62]. Siblings showed an intermediate noise-related task performance, i.e. a non-significant trend to higher force variability than healthy control participants, but a trend for lower variability than patients with schizophrenia.
Association between the loudness dependence of auditory evoked potentials and age in patients with schizophrenia and depression
2022, Journal of International Medical ResearchExperimental serotonergic agents for the treatment of schizophrenia
2021, Journal of Experimental Pharmacology
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Both authors contributed equally to this article.