Letter to the EditorEffects of varenicline on cognitive function in non-smokers with schizophrenia
Section snippets
Declaration of funding source
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Investigator-Initiated Pfizer, Inc. Grant (WI171136)
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Canadian Institutes of Health Research Operating Grant (MOP#115145)
Declaration of conflicts
Dr. George reports that he has funding support from the Canadian Institutes of Health Research (CIHR) and Pfizer, and is a consultant to Novartis. Ms. Kozak, Dr. Dermody, Dr. Tyndale, Dr. Zack, and Dr. Barr report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.
Acknowledgements
This study was support by an Institute of Medical Sciences Graduate Fellowship from the University of Toronto (to Ms. Kozak), an investigator-initiated grant from Pfizer, Inc. (WI171136) and CIHR Operating Grant MOP#115145 (to Dr. George).
References (12)
- et al.
Effects of smoking abstinence on visuospatial working memory function in schizophrenia
Neuropsychopharmacology
(2002) - et al.
Varenicline modulates spatial working memory deficits in smokers with schizophrenia
Schizophr. Res.
(2013) - et al.
A review of the clinical pharmacokinetics and pharmacodynamics of varenicline for smoking cessation
Clin. Pharmacokinet.
(2010) - et al.
Short-term and long-term memory in early temporal lobe dysfunction
Neuropsychology
(1998) - et al.
Effects of moderate-dose treatment with varenicline on neurobiological and cognitive biomarkers in smokers and nonsmokers with schizophrenia or schizoaffective disorder
Arch. Gen. Psychiatry
(2011) - et al.
Varenicline for smoking cessation in schizophrenia: safety and effectiveness in a 12-week, open-label trial
J. Dual Diagn.
(2012)
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Varenicline improves cognitive impairment in a mouse model of mPFC ischemia: The possible roles of inflammation, apoptosis, and synaptic factors
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