Letter to the EditorConsistency between clinician and patient ratings of clozapine-induced side effects
Section snippets
Conflict of interest
Dr. Takeuchi has received fellowship grants from Centre for Addiction and Mental Health (CAMH) Foundation, the Japanese Society of Clinical Neuropsychopharmacology, and Astellas Foundation for Research on Metabolic Disorders, and manuscript fees from Dainippon Sumitomo Pharma.
Mr. Fervaha has no competing interests to disclose.
Dr. Remington has received research support from Novartis, Medicure and Neurocrine Bioscience, consultant fees from Laboratorios Farmacéuticos ROVI, Synchroneuron and
Contributors
Dr. Takeuchi designed the study, conducted the statistical analyses, literature search, and preparation of the first draft of the manuscript. All authors provided significant contributions to the manuscript and have approved the final manuscript.
Acknowledgments
Dr. Takeuchi is supported through the Canadian Institutes of Health Research (CIHR) Fellowship program. This funding source had no role in study design, statistical analysis or interpretation of findings, or in manuscript preparation or submission for publication.
Data used in the preparation of this article were obtained from the limited access datasets (Version 1) distributed from the NIH-supported “Clinical Antipsychotic Trials of Intervention Effectiveness in Schizophrenia” (CATIE-Sz). This
References (10)
- et al.
Glasgow antipsychotic side-effects scale for clozapine — development and validation of a clozapine-specific side-effects scale
Schizophr. Res.
(2015) - et al.
Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: a review and meta-analysis of randomized trials
Am. J. Psychiatry
(2001) - et al.
A self-rating scale for measuring neuroleptic side-effects. Validation in a group of schizophrenic patients
Br. J. Psychiatry
(1995) - et al.
Side-effects and treatment with clozapine: a comparison between the views of consumers and their clinicians
Int. J. Ment. Health Nurs.
(2008) - et al.
Patient-rated versus clinician-rated side effects of drug treatment in schizophrenia
Nord. J. Psychiatry
(2001)
Cited by (4)
Clozapine modulation of zebrafish swimming behavior and gene expression as a case study to investigate effects of atypical drugs on aquatic organisms
2022, Science of the Total EnvironmentCitation Excerpt :It is an indicator that negative side effects are more detectable for general stress response and not for the cardiovascular system. The results imply differences between humans and zebrafish because changes in the heart rate are often detected for atypical antipsychotic medications like clozapine (Ignjatović Ristić et al., 2018; Takeuchi et al., 2016). In conclusion, the present study has demonstrated that clozapine negatively affected the swimming locomotor behavior in zebrafish larvae at environmentally relevant concentrations.
Patient safety: adverse effects of Clozapine and their management at the Psychiatric Hospital Ghrasia in Yogyakarta, Indonesia
2023, Journal of Medicine and Life