Letter to the Editor
Peripubertal treatment with cannabidiol prevents the emergence of psychosis in an animal model of schizophrenia

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Contributors

Fernanda F. Peres, Rodrigo A. Bressan, Antonio W. Zuardi, Jaime E. C. Hallak, José A. Crippa and Vanessa C. Abilio designed the study. Authors Fernanda F. Peres, Mariana C. Diana, Mayra A. Suiama, Verônica Justi and Valéria Almeida conducted the experiments, statistical analysis and managed the literature search. Authors Fernanda F. Peres and Vanessa C. Abilio wrote the first draft of the manuscript. All authors contributed to and have approved the final manuscript.

Conflict of interest

J.E.H., A.W.Z. and J.A.C. are co-inventors of the patent “Fluorinated CBD compounds, compositions and uses thereof. Pub. No.: WO/2014/108899. International Application No.: PCT/IL2014/050023”.

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    However, the variability in protective effects of CBD, much like the adverse effects of THC, could be largely due to dose differences. For example, social deficits induced by either ACE or other risk factors were not remedied by low dose CBD exposure as shown by multiple studies (Peres et al., 2018; Murphy et al., 2017; Peres et al., 2016), however are reversed by high dose CBD treatment (Osborne et al., 2017). Similarly, one study found no protective effect of adolescent CBD on schizophrenia-like behavioural changes in adulthood (Kasten et al., 2019).

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    Among new candidate compounds, accumulating evidence points towards cannabidiol (CBD), the most abundant non-euphoric phytocannabinoid, endowed with a favourable pharmacological profile, as an alternative treatment option for those SCZ symptoms that are not satisfactorily ameliorated by current theraphies [8,9]. In agreement with the hypothesis that early intervention at a critical period (the so-called window of opportunity) may be effective in circumventing the transition to SCZ [10], it has been observed that peripubertal CBD treatment prevents the development of SCZ-like alterations in animal models at adulthood [11,12]. In particular, CBD regulates the mesolimbic DAergic system, which may, at least in part, underlie its behavioral effects [13].

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