Letter to the EditorNovel association of Neuregulin 1 gene with bipolar disorder but not with schizophrenia
Section snippets
Role of the funding source
This research was funded by CIBERSAM, CIBERNED, and Fondo de Investigaciones Sanitarias. Samples and data from patients included in this study were provided by the Basque Biobank for Research-OEHUN (www.biobancovasco.org) and were processed following standard operating procedures with appropriate approval of the Ethical and Scientific Committees. These institutions had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in
Contributors
Ana González-Pinto and Carlos Matute designed the study and wrote the protocol.
Arantza Gutiérrez-Fernández and Aitor Palomino conducted the experiments and Carlos Matute supervised them.
Arantza Gutiérrez-Fernández, Aitor Palomino, Ana González-Pinto and Carlos Matute supervised the data, managed the literature searches and analysis and undertook the statistical analysis.
Ana González-Pinto, Amaia Ugarte, Margarita Hernanz, Begoña Mendíbil, María Etxebeste, Luis Pacheco and Gixane González-García
Conflict of interest
The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
Acknowledgments
The authors gratefully acknowledge the contributions of all psychiatric patients and control volunteers included in the present study; without their cooperation, this work would have not been possible.
This research was funded by CIBERNED (PRY-08-404); European Regional Development Funds (UE/2012/FI-STAR, UE/2013/TENDERMH, UE/2013/MASTERMIND); Grants from Spanish Government (PI12/02077, PI13/02252, PI13/00451); The Basque Foundation for Health Innovation and Research (BIO12/AL/002); the Spanish
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Cited by (8)
Polysialylation and disease
2021, Molecular Aspects of MedicineCitation Excerpt :Many risk alleles have a small effect and sometimes overlap with those for SCZ and other mental disorders. For example, DISC1, NRG1, and BDNF (Gutiérrez-Fernández et al., 2014; Kerner, 2014) were shown to be related to BD. The involvement of ST8SIA2 is also reported to be a generalized susceptibility marker for psychotic and mood disorders on chromosome 15q25-26 (Park et al., 2004).
Neurodevelopmental pathways in bipolar disorder
2020, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Genes related to neurodevelopmental pathways have been implicated in the pathophysiology of BD. For example, polymorphisms in the neuregulin 1 gene and the Reelin gene have been reported to occur more frequently in individuals with BD compared to healthy controls (Cao et al., 2014; Folsom and Fatemi, 2013; Gutierrez-Fernandez et al., 2014). A genetic association study suggested a sex-specific association of polymorphisms in the Reelin gene with BD in females (Goes et al., 2010).
The neurodevelopmental basis of bipolar disorder: Mechanisms and implications
2020, Neurobiology of Bipolar Disorder: Road to Novel TherapeuticsSialic Acids in Neurology
2019, Advances in Carbohydrate Chemistry and BiochemistryCitation Excerpt :Bipolar disorder (BD) is one of the mental disorders that affect people worldwide, and many susceptibility genes have been identified by genome-wide association study (GWAS). For example, DISC1, NRG1, and BDNF231,232 were shown to be related to BD. A number of susceptibility genes for BD partly overlap with those of SZ.
The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies
2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Evidence indicates that neuregulin 1 and its cognate receptor ErB4 play significant roles in the regulation of synaptic transmission, myelin formation, and neuronal and glial cell survival (Mei and Nave, 2014). Although variations in NRG1 gene were initially associated with schizophrenia [see Mostaid et al. (2016) for a review], subsequent studies pointed to a possible association with BD (Cao et al., 2014; Georgieva et al., 2008; Green et al., 2005; Gutierrez-Fernandez et al., 2014), notwithstanding this findings has not been supported thus far by GWAS (Goes, 2016). In keeping with this view, a study found aberrant cleavage of the neuregulin 1 in the post mortem hippocampus of individuals with BD (Marballi et al., 2012).
Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders
2016, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :BD-I patients have had at least one manic episode and BD-II patients have had at least one hypomanic episode and one major depressive episode [127]. BD is one of the most heritable psychiatric disorders and many susceptibility genes have been identified by GWAS and include DISC1, NRG1, and BDNF [128,129]. A number of susceptibility genes for BD partly overlap with SZ.