Letter to the EditorEfficacy and safety of fronto-temporal transcranial random noise stimulation (tRNS) in drug-free patients with schizophrenia: A case study
Section snippets
Role of funding source
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Contributors
MM and JB managed the literature searches and data. MM and FH wrote the first draft of the manuscript. MS and EP supervised the diagnostic assessment of the participant. FH assessed the patient symptoms' evolution. All authors contributed to and have approved the final manuscript.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
The authors thank the “Conseil Scientifique de la Recherche” from The Centre Hospitalier le Vinatier for fundings and Caroline Damasceno, the study nurse of the study. JB is supported by the 2013 NARSAD Young Investigator from the Brain & Behavior Research Foundation (Grant Number 20988).
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Transcranial random noise stimulation for the treatment of negative symptoms in schizophrenia
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Monotherapy with tDCS for schizophrenia: a case report
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Cited by (20)
Boosting psychological change: Combining non-invasive brain stimulation with psychotherapy
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Based on the evidence that monophasic pulses induce stronger and longer-lasting changes in motor cortical excitability (Arai et al., 2007; Tings et al., 2005), a new patterned rTMS protocol was recently introduced. With Quadripulse stimulation (QPS), repeated trains of four monophasic TMS pulses are delivered for ∼30 min with a typical interpulse interval of either 5 ms (inducing LTP-like effects) or 50 ms (inducing LTD-like effects) (Hamada et al., 2007; Hamada and Ugawa, 2010; Huang et al., 2017). Compared to standard rTMS protocols, both patterned protocols induce stronger and longer-lasting effects with lower stimulation intensity and shorter treatment duration, making them the ideal candidates for a safer, time and cost-effective treatment of psychiatric conditions.
Adjunct high-frequency transcranial random noise stimulation over the lateral prefrontal cortex improves negative symptoms of schizophrenia: A randomized, double-blind, sham-controlled pilot study
2021, Journal of Psychiatric ResearchCitation Excerpt :Palm et al. (2013) reported on a case of schizophrenia whose negative symptoms and cognitive deficits were improved by the add-on treatment of unidirectional (i.e., delivering current flow analogously to tDCS via switching the offset from zero to 1 mA to prohibit the oscillations from being negatively polarized) anodal hf-tRNS targeting the left dlPFC. Haesebaert et al. (2014) reported on the other drug-free case of schizophrenia whose positive and negative symptoms, and insight impairment were alleviated by the monotherapy of unidirectional hf-tRNS with fronto-temporal montage. Thus, the therapeutic effects of hf-tRNS in schizophrenia merit systematic investigation.
tDCS as a treatment for anxiety and related cognitive deficits
2020, International Journal of PsychophysiologyCitation Excerpt :Neurological and psychiatric conditions have been found to benefit from tDCS. For example, various forms of tDCS have been applied to patients with depression (Meron et al., 2015), stroke (Yun et al., 2015), tinnitus (Claes et al., 2014), myopia (Camilleri et al., 2014), Parkinson's disease (Benninger and Hallett, 2015), and schizophrenia (Haesebaert et al., 2014) with benefits to associated symptoms (also see Nitsche and Paulus, 2011, for a comprehensive review). While tDCS has been utilized in a number of populations for reduced symptomatology or improved cognitive performance, little work has been done regarding anxiety.
Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)
2017, Clinical NeurophysiologyCitation Excerpt :In fact, tRNS may provide larger MEP size increase and anodal tDCS longer MEP size increase compared to sham, suggesting different underlying mechanisms of action (Moliadze et al., 2014). As tACS, tRNS was also applied in disease context since a couple of years, to provide “therapeutic” improvement, such as the relief of neuropathic pain (Alm and Dreimanis, 2013; Palm et al., 2016a), psychiatric symptoms (Palm et al., 2013a; Haesebaert et al., 2014), or tinnintus (Vanneste et al., 2013a,b; Claes et al., 2014; Joos et al., 2015). These reported clinical effects should be specifically assessed, but largely remain preliminary before being replicated by independent groups in sham-controlled studies.
The efficacy and safety of multiple sessions of multisite transcranial random noise stimulation in treating chronic tinnitus
2019, Brazilian Journal of OtorhinolaryngologyCitation Excerpt :In medicine, when a therapeutic approach is used for managing a disorder or palliating its symptoms, it needs to be cost-effective and safe in order to be approved for the clinical use. There are strong data about the cost-effectiveness and safety of tRNS.24,25 However, by introducing the multisite protocol for tinnitus we aimed in this study to investigate whether the multiple sessions of this protocol can yield more desirable effects without producing any more adverse effects.