Schizophrenia Research
Volume 134, Issue 1 , Pages 10-15 , January 2012

Reduced prepulse inhibition as an early vulnerability marker of the psychosis prodrome in adolescence

  • Tim B. Ziermans

      Affiliations

    • Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    • Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationCorresponding author at: Department of Neuroscience, Retzius Väg 8, Karolinska Institutet, 171 77 Stockholm, Sweden. Tel.: +46 8 524 86 372.
    • ,
  • Patricia F. Schothorst

      Affiliations

    • Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • Mirjam Sprong

      Affiliations

    • Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • Maurice J.C.M. Magnée

      Affiliations

    • Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • Herman van Engeland

      Affiliations

    • Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • Chantal Kemner

      Affiliations

    • Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    • Department of Developmental Psychology, Faculty of Social Sciences, Utrecht University, The Netherlands

Received 18 January 2010 ,Revised 4 October 2011 ,Accepted 20 October 2011.

  • Image Result

    P50 auditory evoked potential of Cz-electrode site in response to the conditioning (C-stimulus) and testing stimuli (T-stimulus) in the control group (left) and the ultra-high risk (UHR) group (middle

    P50 auditory evoked potential of Cz-electrode site in response to the conditioning (C-stimulus) and testing stimuli (T-stimulus) in the control group (left) and the ultra-high risk (UHR) group (middle) and an overlay of the waveforms (right).

  • Image Result
    A. Error bars (mean±1 standard error) of the log-transformed startle amplitudes for pulse alone and prepulse stimuli. The left panel shows data for the total control and ultra-high risk groups and in

    A. Error bars (mean±1 standard error) of the log-transformed startle amplitudes for pulse alone and prepulse stimuli. The left panel shows data for the total control and ultra-high risk groups and in the right panel medicated individuals have been excluded from the UHR group. B. Total percentage prepulse inhibition for UHR individuals based on medication type. AD=antidepressant; AP=antipsychotic; St=psychostimulant; AC=anticonvulsant (used as mood stabilizer).

  • Image Result
    Smooth pursuit eye movements as a function of velocity gain (left) and number of saccades per second (right) for ultra-high risk (UHR) individuals (red) and typically developing controls (blue).

    Smooth pursuit eye movements as a function of velocity gain (left) and number of saccades per second (right) for ultra-high risk (UHR) individuals (red) and typically developing controls (blue).

PII: S0920-9964(11)00544-5

doi: 10.1016/j.schres.2011.10.009

Schizophrenia Research
Volume 134, Issue 1 , Pages 10-15 , January 2012

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