Schizophrenia Research
Volume 134, Issue 1 , Pages 1-9 , January 2012

Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study

  • Dylan G. Gee

      Affiliations

    • University of California, Los Angeles, Departments of Psychology and Psychiatry, Los Angeles, CA, USA
    • ,
  • Katherine H. Karlsgodt

      Affiliations

    • University of California, Los Angeles, Departments of Psychology and Psychiatry, Los Angeles, CA, USA
    • ,
  • Theo G.M. van Erp

      Affiliations

    • Department of Psychiatry, University of California Irvine, USA
    • ,
  • Carrie E. Bearden

      Affiliations

    • University of California, Los Angeles, Departments of Psychology and Psychiatry, Los Angeles, CA, USA
    • ,
  • Matthew D. Lieberman

      Affiliations

    • University of California, Los Angeles, Departments of Psychology and Psychiatry, Los Angeles, CA, USA
    • ,
  • Aysenil Belger

      Affiliations

    • University of North Carolina, Chapel Hill, Department of Psychiatry, Chapel Hill, NC, USA
    • ,
  • Diana O. Perkins

      Affiliations

    • University of North Carolina, Chapel Hill, Department of Psychiatry, Chapel Hill, NC, USA
    • ,
  • Doreen M. Olvet

      Affiliations

    • Zucker Hillside Hospital, Department of Psychiatry Research, Glen Oaks, NY, USA
    • ,
  • Barbara A. Cornblatt

      Affiliations

    • Zucker Hillside Hospital, Department of Psychiatry Research, Glen Oaks, NY, USA
    • ,
  • Todd Constable

      Affiliations

    • Yale University, Department of Psychiatry, New Haven, CT, USA
    • ,
  • Scott W. Woods

      Affiliations

    • Yale University, Department of Psychiatry, New Haven, CT, USA
    • ,
  • Jean Addington

      Affiliations

    • University of Calgary, Department of Psychiatry, Calgary, Alberta, Canada
    • ,
  • Kristin S. Cadenhead

      Affiliations

    • University of California, San Diego, Department of Psychiatry, La Jolla, CA, USA
    • ,
  • Thomas H. McGlashan

      Affiliations

    • Yale University, Department of Psychiatry, New Haven, CT, USA
    • ,
  • Larry J. Seidman

      Affiliations

    • Beth Israel Deaconess Medical Center, Department of Psychiatry, Boston, MA, USA
    • ,
  • Ming T. Tsuang

      Affiliations

    • University of California, San Diego, Department of Psychiatry, La Jolla, CA, USA
    • ,
  • Elaine F. Walker

      Affiliations

    • Emory University, Department of Psychology, Atlanta, GA, USA
    • ,
  • Tyrone D. Cannon

      Affiliations

    • University of California, Los Angeles, Departments of Psychology and Psychiatry, Los Angeles, CA, USA
    • Corresponding Author InformationCorresponding author at: University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095–1563. Tel.: +1 310 794 9673; fax: +1 310 794 9740.
    • ,
  • on behalf of the NAPLS Consortium

      Affiliations

    • A complete list of study personnel involved in the NAPLS Consortium appears in the Appendix.

Received 23 April 2011 ,Revised 6 October 2011 ,Accepted 13 October 2011.

  • Image Result

    Task design. The emotional faces fMRI task consisted of emotion labeling and emotion matching, as well as non-emotional control conditions of gender labeling, gender matching, and shape matching (adap

    Task design. The emotional faces fMRI task consisted of emotion labeling and emotion matching, as well as non-emotional control conditions of gender labeling, gender matching, and shape matching (adapted from Lieberman et al., 2007).

  • Image Result
    Regions of interest. Regions of interest for the left amygdala (left) and right vlPFC (right) are shown. For the left amygdala, an anatomical ROI was used based on the probabilistic Harvard–Oxford Str

    Regions of interest. Regions of interest for the left amygdala (left) and right vlPFC (right) are shown. For the left amygdala, an anatomical ROI was used based on the probabilistic Harvard–Oxford Structural Atlas. The right vlPFC ROI mask was created using a spherical ROI centered at 56, 22, 8, a peak of activation for emotion labeling versus gender labeling in a study of healthy controls (Lieberman et al., 2007).

  • Image Result
    vlPFC Trajectories. Analysis of the right vlPFC revealed a significant interaction (F(4,29)=5.43, p=.027) between age-related trajectories of functional activation during emotion labeling versus gende

    vlPFC Trajectories. Analysis of the right vlPFC revealed a significant interaction (F(4,29)=5.43, p=.027) between age-related trajectories of functional activation during emotion labeling versus gender labeling for CHR patients and controls, such that controls showed increasing vlPFC activation whereas CHR patients showed decreasing vlPFC activation across development.

  • Image Result
    Amygdala Trajectories. Regression analysis demonstrated a significant interaction (F(4,28)=4.84, p=.037) between age-related trajectories of left amygdala activation during emotion labeling versus emo

    Amygdala Trajectories. Regression analysis demonstrated a significant interaction (F(4,28)=4.84, p=.037) between age-related trajectories of left amygdala activation during emotion labeling versus emotion matching for CHR patients and controls, such that controls exhibited decreasing amygdala activation whereas CHR patients showed increasing amygdala activation with increasing age.

  • Image Result
    Amygdala–prefrontal functional connectivity. CHR patients demonstrated weaker inverse task-dependent functional connectivity between the amygdala and prefrontal regions consisting of left orbitofronta

    Amygdala–prefrontal functional connectivity. CHR patients demonstrated weaker inverse task-dependent functional connectivity between the amygdala and prefrontal regions consisting of left orbitofrontal cortex and left inferior frontal gyrus, compared with controls (Z=3.82, p=.027, corrected).

PII: S0920-9964(11)00540-8

doi: 10.1016/j.schres.2011.10.005

Schizophrenia Research
Volume 134, Issue 1 , Pages 1-9 , January 2012

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