Schizophrenia Research
Volume 127, Issue 1 , Pages 115-122 , April 2011

Probabilistic learning and inference in schizophrenia

  • Bruno B. Averbeck

      Affiliations

    • Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-4415, United States
    • Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, WC1N 3BG, UK
    • Corresponding Author InformationCorresponding author. Bldg. 49, Room 1B-80, National Institute of Mental Health, Bethesda, MD 20892-4415, United States. Tel.: +1 301 594 1126.
  • ,
  • Simon Evans

      Affiliations

    • Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, WC1N 3BG, UK
  • ,
  • Viraj Chouhan

      Affiliations

    • King's College London, Cognition Schizophrenia and Imaging Lab, Department of Psychosis Studies, UK
  • ,
  • Eleanor Bristow

      Affiliations

    • King's College London, Cognition Schizophrenia and Imaging Lab, Department of Psychosis Studies, UK
  • ,
  • Sukhwinder S. Shergill

      Affiliations

    • King's College London, Cognition Schizophrenia and Imaging Lab, Department of Psychosis Studies, UK

Received 21 July 2010 ,Revised 30 July 2010 ,Accepted 5 August 2010.

References 

  1. Abi-Dargham A, Gil R, Krystal J, Baldwin RM, Seibyl JP, Bowers M, et al. Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort. Am. J. Psychiatry. 1998;155:761–767
  2. Breier A, Su TP, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A, et al. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc. Natl. Acad. Sci. U.S.A. 1997;94:2569–2574
  3. Corcoran R, Rowse G, Moore R, Blackwood N, Kinderman P, Howard R, et al. A transdiagnostic investigation of ‘theory of mind’ and ‘jumping to conclusions’ in patients with persecutory delusions. Psychol. Med. 2008;38:1577–1583
  4. Dudley RE, John CH, Young AW, Over DE. Normal and abnormal reasoning in people with delusions. Br. J. Clin. Psychol. 1997;36(Pt 2):243–258
  5. Fine C, Gardner M, Craigie J, Gold I. Hopping, skipping or jumping to conclusions? Clarifying the role of the JTC bias in delusions. Cogn. Neuropsychiatry. 2007;12:46–77
  6. Frank MJ, O'Reilly RC. A mechanistic account of striatal dopamine function in human cognition: psychopharmacological studies with cabergoline and haloperidol. Behav. Neurosci. 2006;120:497–517
  7. Frank MJ, Seeberger LC, O'Reilly RC. By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science. 2004;306:1940–1943
  8. Frank MJ, Moustafa AA, Haughey HM, Curran T, Hutchison KE. Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proc. Natl. Acad. Sci. U.S.A. 2007;104:16311–16316
  9. Garety PA, Freeman D. Cognitive approaches to delusions: a critical review of theories and evidence. Br. J. Clin. Psychol. 1999;38(Pt 2):113–154
  10. Garety PA, Hemsley DR, Wessely S. Reasoning in deluded schizophrenic and paranoid patients. Biases in performance on a probabilistic inference task. J. Nerv. Ment. Dis. 1991;179:194–201
  11. Garety PA, Freeman D, Jolley S, Dunn G, Bebbington PE, Fowler DG, et al. Reasoning, emotions, and delusional conviction in psychosis. J. Abnorm. Psychol. 2005;114:373–384
  12. Gigerenzer G, Todd PM. Simple Heuristics That Make Us Smart. Oxford: Oxford; 1999;
  13. Glockner A, Moritz S. A fine-grained analysis of the jumping-to-conclusions bias in schizophrenia: data-gathering, response confidence, and information integration. Judgm. Decis. Mak. 2009;4:587–600
  14. Huq SF, Garety PA, Hemsley DR. Probabilistic judgements in deluded and non-deluded subjects. Q. J. Exp. Psychol. A. 1988;40:801–812
  15. Kapur S, Mizrahi R, Li M. From dopamine to salience to psychosis—linking biology, pharmacology and phenomenology of psychosis. Schizophr. Res. 2005;79:59–68
  16. Klein TA, Neumann J, Reuter M, Hennig J, von Cramon DY, Ullsperger M. Genetically determined differences in learning from errors. Science. 2007;318:1642–1645
  17. Langdon R, Ward PB, Coltheart M. Reasoning anomalies associated with delusions in schizophrenia. Schizophr. Bull. 2010;36:321–330
  18. LaRocco VA, Warman DM. Probability estimations and delusion-proneness. Pers. Individ. Differ. 2009;47:197–202
  19. Laruelle M, Abi-Dargham A, van Dyck CH, Gil R, D'Souza CD, Erdos J, et al. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc. Natl. Acad. Sci. U.S.A. 1996;93:9235–9240
  20. Lincoln TM, Ziegler M, Mehl S, Rief W. The jumping to conclusions bias in delusions: specificity and changeability. J. Abnorm. Psychol. 2010;119:40–49
  21. Moritz S, Woodward TS. Memory confidence and false memories in schizophrenia. J. Nerv. Ment. Dis. 2002;190:641–643
  22. Moritz S, Woodward TS. Jumping to conclusions in delusional and non-delusional schizophrenic patients. Br. J. Clin. Psychol. 2005;44:193–207
  23. Moritz S, Woodward TS. The contribution of metamemory deficits to schizophrenia. J. Abnorm. Psychol. 2006;115:15–25
  24. Moritz S, Woodward TS, Whitman JC, Cuttler C. Confidence in errors as a possible basis for delusions in schizophrenia. J. Nerv. Ment. Dis. 2005;193:9–16
  25. Moritz S, Woodward TS, Chen E. Investigation of metamemory dysfunctions in first-episode schizophrenia. Schizophr. Res. 2006;81:247–252
  26. Moritz S, Woodward TS, Lambert M. Under what circumstances do patients with schizophrenia jump to conclusions? A liberal acceptance account. Br. J. Clin. Psychol. 2007;46:127–137
  27. Moritz S, Veckenstedt R, Randjbar S, Hottenrott B, Woodward TS, von Eckstaedt FV, et al. Decision making under uncertainty and mood induction: further evidence for liberal acceptance in schizophrenia. Psychol. Med. 2009;39:1821–1829
  28. Pessiglione M, Seymour B, Flandin G, Dolan RJ, Frith CD. Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature. 2006;442:1042–1045
  29. Schultz W. Getting formal with dopamine and reward. Neuron. 2002;36:241–263
  30. Seeman P, Lee T, Chau-Wong M, Wong K. Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature. 1976;261:717–719
  31. Seo, M., Beigi M., Jahanshahi M., Averbeck B.B., in press. Effects of dopamine medication on sequence learning with stochastic feedback in Parkinson's disease. Front. Neurosci. doi:10.3389/fnsys.2010.00036.
  32. Speechley WJ, Whitman JC, Woodward TS. The contribution of hypersalience to the “jumping to conclusions” bias associated with delusions in schizophrenia. J. Psychiatry Neurosci. 2010;35:7–17
  33. Van Dael F, Versmissen D, Janssen I, Myin-Germeys I, van Os J, Krabbendam L. Data gathering: biased in psychosis?. Schizophr. Bull. 2006;32:341–351
  34. van der Gaag M, Hoffman T, Remijsen M, Hijman R, de Haan L, van Meijel B, et al. The five-factor model of the Positive and Negative Syndrome Scale II: a ten-fold cross-validation of a revised model. Schizophr. Res. 2006;85:280–287
  35. Waltz JA, Frank MJ, Robinson BM, Gold JM. Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal–cortical dysfunction. Biol. Psychiatry. 2007;62:756–764
  36. Warman DM. Reasoning and delusion proneness: confidence in decisions. J. Nerv. Ment. Dis. 2008;196:9–15
  37. Warman DM, Lysaker PH, Martin JM, Davis L, Haudenschield SL. Jumping to conclusions and the continuum of delusional beliefs. Behav. Res. Ther. 2007;45:1255–1269
  38. Young HF, Bentall RP. Probabilistic reasoning in deluded, depressed and normal subjects: effects of task difficulty and meaningful versus non-meaningful material. Psychol. Med. 1997;27:455–465
  39. Ziegler M, Rief W, Werner SM, Mehl S, Lincoln TM. Hasty decision-making in a variety of tasks: does it contribute to the development of delusions?. Psychol. Psychother. 2008;81:237–245

PII: S0920-9964(10)01455-6

doi: 10.1016/j.schres.2010.08.009

Schizophrenia Research
Volume 127, Issue 1 , Pages 115-122 , April 2011