Schizophrenia Research
Volume 124, Issue 1 , Pages 236-237 , December 2010

A case–control study and meta-analysis of association between a common copy number variation of the glutathione S-transferase mu 1 (GSTM1) gene and schizophrenia

  • Yuichiro Watanabe

      Affiliations

    • Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan
    • Health Administration Center, Niigata University, 8050 Ikarashi-ninocho, Nishi-ku, Niigata 950-2181, Japan
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan. Tel.: +81 25 227 2213; fax: +81 25 227 0777.
    • ,
  • Ayako Nunokawa

      Affiliations

    • Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan
    • ,
  • Naoshi Kaneko

      Affiliations

    • Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan
    • ,
  • Toshiyuki Someya

      Affiliations

    • Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan

Received 11 June 2010 ,Revised 2 August 2010 ,Accepted 2 August 2010.

References 

  1. Harada S, Tachikawa H, Kawanishi Y. Glutathione S-transferase M1 gene deletion may be associated with susceptibility to certain forms of schizophrenia. Biochem. Biophys. Res. Commun. 2001;281(2):267–271
  2. Huang RS, Chen P, Wisel S, Duan S, Zhang W, Cook EH, et al. Population-specific GSTM1 copy number variation. Hum. Mol. Genet. 2009;18(2):366–372
  3. Matsuzawa D, Hashimoto K, Hashimoto T, Shimizu E, Watanabe H, Fujita Y, et al. Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009;150B(1):86–94
  4. Pae C-U, Yu H-S, Kim J-J, Kim W, Lee C-U, Lee S-J, et al. Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population. Psychiatr. Genet. 2004;14(3):147–150
  5. Rodríguez-Santiago B, Brunet A, Sobrino B, Serra-Juhé C, Flores R, Armengol L, et al. Association of common copy number variants at the glutathione S-transferase genes and rare novel genomic changes with schizophrenia. Mol. Psychiatry. 2009;
  6. Seidegård J, Vorachek WR, Pero RW, Pearson WR. Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc. Natl Acad. Sci. USA. 1988;85(19):7293–7297
  7. Tam GW, Redon R, Carter NP, Grant SG. The role of DNA copy number variation in schizophrenia. Biol. Psychiatry. 2009;66(11):1005–1012
  8. Watanabe Y, Muratake T, Kaneko N, Nunokawa A, Someya T. No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population. Schizophr. Res. 2006;84(1):29–35
  9. Watanabe Y, Nunokawa A, Kaneko N, Someya T. Meta-analysis of case-control association studies between the C270T polymorphism of the brain-derived neurotrophic factor gene and schizophrenia. Schizophr. Res. 2007;95(1–3):250–252
  10. Wood SJ, Yücel M, Pantelis C, Berk M. Neurobiology of schizophrenia spectrum disorders: the role of oxidative stress. Ann. Acad. Med. Singapore. 2009;38(5):296–396

PII: S0920-9964(10)01447-7

doi: 10.1016/j.schres.2010.08.001

Schizophrenia Research
Volume 124, Issue 1 , Pages 236-237 , December 2010

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