Schizophrenia Research
Volume 124, Issue 1 , Pages 246-247 , December 2010

Fragile X mental retardation protein levels are decreased in major psychiatric disorders

  • S. Hossein Fatemi

      Affiliations

    • Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, United States
    • Department of Pharmacology, University of Minnesota, Medical School, 310 Church St. SE, Minneapolis, MN 55455, United States
    • Department of Neuroscience, University of Minnesota, Medical School, 310 Church St. SE, Minneapolis, MN 55455, United States
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Medical School, MMC 392, 420 Delaware St. S.E., Minneapolis, MN 55455, United States. Tel.: +1 612 626 3633; fax: +1 612 624 8935.
    • ,
  • Rachel E. Kneeland

      Affiliations

    • Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, United States
    • ,
  • Stephanie B. Liesch

      Affiliations

    • Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, United States
    • ,
  • Timothy D. Folsom

      Affiliations

    • Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, United States

Received 2 June 2010 ,Revised 9 July 2010 ,Accepted 13 July 2010.

References 

  1. Ashworth A, Abusaad I, Walsh C, Nanko S, Murray RM, Asherson P, et al. Linkage analysis of the fragile X gene FMR-1 and schizophrenia: no evidence for linkage but report of a family with schizophrenia and an unstable triplet repeat. Psychiatr. Genet. 1996;6(2):81–86
  2. Brown V, Ceman S, Darnell JC, O'Donnell WT, Tenenbaum SA, Jin X, et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell. 2001;107(4):477–487
  3. Demark J, Feldman M, Holden J. Behavioral relationship between autism and fragile X syndrome. Am. J. Ment. Retard. 2003;108(1):314–326
  4. De Rubeis S, Bagni C. Fragile X mental retardation protein control of neuronal mRNA metabolism: Insights into mRNA stability. Mol. Cell. Neurosci. 2010;43(1):43–50
  5. Fatemi, S.H., Folsom, T.D., in press. FMRP is reduced in the cerebella of subjects with autism. Iranaian J. Psychiatr. Behav. Neurosci.
  6. Fatemi SH, Earle JA, Stary JM, Lee S, Sedgewick J. Altered levels of the synaptosomal associated protein SNAP-25 in hippocampus of subjects with mood disorders and schizophrenia. NeuroReport. 2001;12(15):3257–3262
  7. Fatemi SH, Reutiman TJ, Folsom TD, Lee S. Phosphodiesterase 4A expression is reduced in cerebella of subjects with bipolar disorder. Psychiatr. Genet. 2008;18(6):282–288
  8. Fatemi, S.H., Folsom, T.D., Kneeland, R.E., Liesch, S.B., in press. Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism. Anat. Record.
  9. Fatemi, S.H., Folsom, T.D., Rooney, R.J., Patel, D.H., Thuras, P., submitted for publication. mRNA from the FMR1 gene and protein levels of Fragile X mental retardation protein are reduced in superior frontal cortex of adults with autism.
  10. Jnsson E, Björck E, Wahlström J, Gustavsson P, Sedvall G. Screening for CGG trinucleotide repeat expansion in the fragile X mental retardation 1 gene in schizophrenic patients. Psychiatr. Genet. 1995;5(4):157–160
  11. Tam GW, van de Lagemaat LN, Redon R, Strathdee KE, Croning MD, Malloy MP, et al. Confirmed rare copy variants implicate novel genes in schizophrenia. Biochem. Soc. Trans. 2010;38(2):445–451
  12. Oostra BA, Willemsen R. FMR1: a gene with three faces. Biochim. Biophys. Acta. 2009;1790:467–477

PII: S0920-9964(10)01432-5

doi: 10.1016/j.schres.2010.07.017

Schizophrenia Research
Volume 124, Issue 1 , Pages 246-247 , December 2010

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