Schizophrenia Research
Volume 123, Issue 1 , Pages 22-29 , October 2010

Left dorsolateral prefrontal cortex dysfunction in medication-naive schizophrenia

  • Nicoletta M.J. van Veelen

      Affiliations

    • Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    • Corresponding Author InformationCorresponding author. Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Room A.00.241, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands. Tel.: +31 88 7558180; fax: +31 88 7555443.
    • ,
  • Matthijs Vink

      Affiliations

    • Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • Nick F. Ramsey

      Affiliations

    • Rudolf Magnus Institute of Neuroscience, Department of Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • René S. Kahn

      Affiliations

    • Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands

Received 31 January 2010 ,Revised 23 June 2010 ,Accepted 12 July 2010.

References 

  1. Andreasen NC, Flaum M, Arndt S. The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch. Gen. Psychiatry. 1992;49:615–623
  2. Andreasen NC, Rezai K, Alliger R, Swayze VW, Flaum M, Kirchner P, et al. Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single-photon emission computed tomography and the Tower of London. Arch. Gen. Psychiatry. 1992;49:943–958
  3. Antonova E, Sharma T, Morris R, Kumari V. The relationship between brain structure and neurocognition in schizophrenia: a selective review. Schizophr. Res. 2004;70:117–145
  4. Arce E, Leland DS, Miller DA, Simmons AN, Winternheimer KC, Paulus MP. Individuals with schizophrenia present hypo- and hyperactivation during implicit cueing in an inhibitory task. Neuroimage. 2006;32:704–713
  5. Barch DM, Carter CS, Braver TS, Sabb FW, MacDonald A, Noll DC, et al. Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Arch. Gen. Psychiatry. 2001;58:280–288
  6. Beauchamp MH, Dagher A, Aston JA, Doyon J. Dynamic functional changes associated with cognitive skill learning of an adapted version of the Tower of London task. Neuroimage. 2003;20:1649–1660
  7. Buchsbaum MS, Haier RJ, Potkin SG, Nuechterlein K, Bracha HS, Katz M, et al. Frontostriatal disorder of cerebral metabolism in never-medicated schizophrenics. Arch. Gen. Psychiatry. 1992;49:935–942
  8. Cahn W, van Haren NE, Hulshoff Pol HE, Schnack HG, Caspers E, Laponder DA, et al. Brain volume changes in the first year of illness and 5-year outcome of schizophrenia. Br. J. Psychiatry. 2006;189:381–382
  9. Callicott JH, Mattay VS, Bertolino A, Finn K, Coppola R, Frank JA, et al. Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb. Cortex. 1999;9:20–26
  10. Callicott JH, Bertolino A, Egan MF, Mattay VS, Langheim FJ, Weinberger DR. Selective relationship between prefrontal N-acetylaspartate measures and negative symptoms in schizophrenia. Am. J. Psychiatry. 2000;157:1646–1651
  11. Callicott JH, Bertolino A, Mattay VS, Langheim FJ, Duyn J, Coppola R, et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb. Cortex. 2000;10:1078–1092
  12. Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR. Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am. J. Psychiatry. 2003;160:2209–2215
  13. Collins DL, Neelin P, Peters TM, Evans AC. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J. Comput. Assist. Tomogr. 1994;18:192–205
  14. First M, Spitzer R, Gibbon M, Williams JBW. Interview for DSM-IV Axis I Disorders — Patient Edition (SCID-I/P, Version 2.0). 1996;
  15. Friston KJ, Frith CD, Turner R, Frackowiak RS. Characterizing evoked hemodynamics with fMRI. Neuroimage. 1995;2:157–165
  16. Garavan H, Kelley D, Rosen A, Rao SM, Stein EA. Practice-related functional activation changes in a working memory task. Microsc. Res. Tech. 2000;51:54–63
  17. Glantz LA, Gilmore JH, Lieberman JA, Jarskog LF. Apoptotic mechanisms and the synaptic pathology of schizophrenia. Schizophr. Res. 2006;81:47–63
  18. Goldberg TE, Patterson KJ, Taqqu Y, Wilder K. Capacity limitations in short-term memory in schizophrenia: tests of competing hypotheses. Psychol. Med. 1998;28:665–673
  19. Gonzalez-Burgos G, Lewis DA. GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia. Schizophr. Bull. 2008;34:944–961
  20. Gur RE, Cowell P, Turetsky BI, Gallacher F, Cannon T, Bilker W, et al. A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Arch. Gen. Psychiatry. 1998;55:145–152
  21. Hazlett EA, Buchsbaum MS, Haznedar MM, Newmark R, Goldstein KE, Zelmanova Y, et al. Cortical gray and white matter volume in unmedicated schizotypal and schizophrenia patients. Schizophr. Res. 2008;101:111–123
  22. Ho BC, Andreasen NC, Nopoulos P, Arndt S, Magnotta V, Flaum M. Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia. Arch. Gen. Psychiatry. 2003;60:585–594
  23. Honey GD, Sharma T, Suckling J, Giampietro V, Soni W, Williams SC, et al. The functional neuroanatomy of schizophrenic subsyndromes. Psychol. Med. 2003;33:1007–1018
  24. Hulshoff Pol HE, Kahn RS. What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia. Schizophr. Bull. 2008;34:354–366
  25. Hyde JS. The gender similarities hypothesis. Am. Psychol. 2005;60:581–592
  26. Jager G, Kahn RS, Van Den BW, Van Ree JM, Ramsey NF. Long-term effects of frequent cannabis use on working memory and attention: an fMRI study. Psychopharmacology (Berl). 2006;185:358–368
  27. Jansma JM, Ramsey NF, Slagter HA, Kahn RS. Functional anatomical correlates of controlled and automatic processing. J. Cogn. Neurosci. 2001;13:730–743
  28. Jansma JM, Ramsey NF, van der Wee NJ, Kahn RS. Working memory capacity in schizophrenia: a parametric fMRI study. Schizophr. Res. 2004;68:159–171
  29. Jarskog LF, Glantz LA, Gilmore JH, Lieberman JA. Apoptotic mechanisms in the pathophysiology of schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2005;29:846–858
  30. Job DE, Whalley HC, Johnstone EC, Lawrie SM. Grey matter changes over time in high risk subjects developing schizophrenia. Neuroimage. 2005;25:1023–1030
  31. Karlsgodt KH, Glahn DC, van Erp TG, Therman S, Huttunen M, Manninen M, et al. The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophr. Res. 2007;89:191–197
  32. Karlsgodt KH, Sanz J, van Erp TG, Bearden CE, Nuechterlein KH, Cannon TD. Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia. Schizophr. Res. 2009;108:143–150
  33. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 1987;13:261–276
  34. Kelly C, Foxe JJ, Garavan H. Patterns of normal human brain plasticity after practice and their implications for neurorehabilitation. Arch. Phys. Med. Rehabil. 2006;87:S20–S29
  35. Kriegeskorte N, Simmons WK, Bellgowan PS, Baker CI. Circular analysis in systems neuroscience: the dangers of double dipping. Nat. Neurosci. 2009;12:535–540
  36. Lahti AC, Holcomb HH, Medoff DR, Weiler MA, Tamminga CA, Carpenter WT. Abnormal patterns of regional cerebral blood flow in schizophrenia with primary negative symptoms during an effortful auditory recognition task. Am. J. Psychiatry. 2001;158:1797–1808
  37. Landau SM, Schumacher EH, Garavan H, Druzgal TJ, D'Esposito M. A functional MRI study of the influence of practice on component processes of working memory. Neuroimage. 2004;22:211–221
  38. Liddle PF. Regional brain abnormalities associated with specific syndromes of persistent schizophrenic symptoms. Clin. Neuropharmacol. 1992;15(Suppl 1 Pt A):401A–402A
  39. Manoach DS. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophr. Res. 2003;60:285–298
  40. Manoach DS, Gollub RL, Benson ES, Searl MM, Goff DC, Halpern E, et al. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol. Psychiatry. 2000;48:99–109
  41. Meisenzahl EM, Scheuerecker J, Zipse M, Ufer S, Wiesmann M, Frodl T, et al. Effects of treatment with the atypical neuroleptic quetiapine on working memory function: a functional MRI follow-up investigation. Eur. Arch. Psychiatry Clin. Neurosci. 2006;256:522–531
  42. Milham MP, Banich MT, Claus ED, Cohen NJ. Practice-related effects demonstrate complementary roles of anterior cingulate and prefrontal cortices in attentional control. Neuroimage. 2003;18:483–493
  43. Molina V, Reig S, Pascau J, Sanz J, Sarramea F, Gispert JD, et al. Anatomical and functional cerebral variables associated with basal symptoms but not risperidone response in minimally treated schizophrenia. Psychiatry Res. 2003;124:163–175
  44. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9:97–113
  45. Pantelis C, Yucel M, Wood SJ, Velakoulis D, Sun D, Berger G, et al. Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia. Schizophr. Bull. 2005;31:672–696
  46. Pantelis C, Velakoulis D, Wood SJ, Yucel M, Yung AR, Phillips LJ, et al. Neuroimaging and emerging psychotic disorders: the Melbourne ultra-high risk studies. Int. Rev. Psychiatry. 2007;19:371–381
  47. Ragland JD, Gur RC, Glahn DC, Censits DM, Smith RJ, Lazarev MG, et al. Frontotemporal cerebral blood flow change during executive and declarative memory tasks in schizophrenia: a positron emission tomography study. Neuropsychology. 1998;12:399–413
  48. Ramsey NF, van den Brink JS, van Muiswinkel AM, Folkers PJ, Moonen CT, Jansma JM, et al. Phase navigator correction in 3D fMRI improves detection of brain activation: quantitative assessment with a graded motor activation procedure. Neuroimage. 1998;8:240–248
  49. Ramsey NF, Jansma JM, Jager G, Van RT, Kahn RS. Neurophysiological factors in human information processing capacity. Brain. 2004;127:517–525
  50. Riehemann S, Volz HP, Stutzer P, Smesny S, Gaser C, Sauer H. Hypofrontality in neuroleptic-naive schizophrenic patients during the Wisconsin Card Sorting Test — a fMRI study. Eur. Arch. Psychiatry Clin. Neurosci. 2001;251:66–71
  51. Sanz JH, Karlsgodt KH, Bearden CE, van Erp TG, Nandy RR, Ventura J, et al. Symptomatic and functional correlates of regional brain physiology during working memory processing in patients with recent onset schizophrenia. Psychiatry Res. 2009;173:177–182
  52. Sayala S, Sala JB, Courtney SM. Increased neural efficiency with repeated performance of a working memory task is information-type dependent. Cereb. Cortex. 2006;16:609–617
  53. Schmidt H, Jogia J, Fast K, Christodoulou T, Haldane M, Kumari V, et al. No gender differences in brain activation during the N-back task: an fMRI study in healthy individuals. Hum. Brain Mapp. 2009;30:3609–3615
  54. Selemon LD, Goldman-Rakic PS. The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biol. Psychiatry. 1999;45:17–25
  55. Selemon LD, Mrzljak J, Kleinman JE, Herman MM, Goldman-Rakic PS. Regional specificity in the neuropathologic substrates of schizophrenia: a morphometric analysis of Broca's area 44 and area 9. Arch. Gen. Psychiatry. 2003;60:69–77
  56. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry. 1998;59(Suppl 20):22–33
  57. Snitz BE, MacDonald A, Cohen JD, Cho RY, Becker T, Carter CS. Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatment. Am. J. Psychiatry. 2005;162:2322–2329
  58. Stephan KE, Friston KJ, Frith CD. Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring. Schizophr. Bull. 2009;35:509–527
  59. Sternberg S. High-speed scanning in human memory. Science. 1966;153:652–654
  60. van Gelderen P, Ramsey NF, Liu G, Duyn JH, Frank JA, Weinberger DR, et al. Three-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner. Proc. Natl Acad. Sci. USA. 1995;92:6906–6910
  61. van Raalten TR, Ramsey NF, Jansma JM, Jager G, Kahn RS. Automatization and working memory capacity in schizophrenia. Schizophr. Res. 2008;100:161–171
  62. Weinberger DR, Berman KF, Suddath R, Torrey EF. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. Am. J. Psychiatry. 1992;149:890–897
  63. Williams LM, Whitford TJ, Gordon E, Gomes L, Brown KJ, Harris AW. Neural synchrony in patients with a first episode of schizophrenia: tracking relations with grey matter and symptom profile. J. Psychiatry Neurosci. 2009;34:21–29
  64. Wolf RC, Vasic N, Hose A, Spitzer M, Walter H. Changes over time in frontotemporal activation during a working memory task in patients with schizophrenia. Schizophr. Res. 2007;91:141–150
  65. Yurgelun-Todd DA, Waternaux CM, Cohen BM, Gruber SA, English CD, Renshaw PF. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am. J. Psychiatry. 1996;153:200–205

PII: S0920-9964(10)01419-2

doi: 10.1016/j.schres.2010.07.004

Schizophrenia Research
Volume 123, Issue 1 , Pages 22-29 , October 2010

Article Tools

* Image Usage & Resolution