Schizophrenia Research
Volume 122, Issue 1 , Pages 81-84 , September 2010

Reduced gray matter in the anterior cingulate gyrus in familial schizophrenia: A preliminary report

  • Gregory Costain

      Affiliations

    • Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    • ,
  • Andrew Ho

      Affiliations

    • Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    • ,
  • Adrian P. Crawley

      Affiliations

    • Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • David J. Mikulis

      Affiliations

    • Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Linda M. Brzustowicz

      Affiliations

    • Department of Genetics, Rutgers University, Piscataway, New Jersey, USA
    • ,
  • Eva W.C. Chow

      Affiliations

    • Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    • Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Anne S. Bassett

      Affiliations

    • Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    • Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationCorresponding author. Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1. Tel.: +1 416 535 8501x2731; fax: +1 416 535 7199.

Received 10 March 2010 ,Revised 21 June 2010 ,Accepted 22 June 2010.

References 

  1. Bassett AS, Collins EJ, Nuttall SE, Honer WG. Positive and negative symptoms in families with schizophrenia. Schizophr. Res. 1993;11:9–19
  2. Brzustowicz LM, Hodgkinson KA, Chow EWC, Honer WG, Bassett AS. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21–q22. Science. 2000;288:678–682
  3. Filbey FM, Russell T, Morris RG, Murray RM, McDonald C. Functional magnetic resonance imaging (fMRI) of attention processes in presumed obligate carriers of schizophrenia: preliminary findings. Ann. Gen. Psychiatry. 2008;7:18
  4. Fornito A, Yucel M, Dean B, Wood SJ, Pantelis C. Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology. Schizophr. Bull. 2009;35:973–993
  5. Goghari VM, Rehm K, Carter CS, MacDonald AW. Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients. Cereb. Cortex. 2007;17:415–424
  6. Honea R, Crow TJ, Passingham D, Mackay CE. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am. J. Psychiatry. 2005;162:2233–2245
  7. Husted J, Lim S, Chow EWC, Greenwood C, Bassett AS. Heritability of neurocognitive traits in familial schizophrenia. Am. J. Med. Genet. B. 2009;150B:845–853
  8. Jernigan TL, Archibald SL, Berhow MT, Sowell ER, Foster DS, Hesselink JR. Cerebral structure on MRI, Part I: Localization of age-related changes.. Biol. Psychiatry. 1991;29:55–67
  9. Voormolen EHJ, Wei C, Chow EWC, Bassett AS, Mikulis D, Crawley AP. Voxel-based morphometry and automated lobar region of interest volumetry: the trade-off between spatial scale and statistical correction. Neuroimage. 2010;49:587–596
  10. Wratten N, Memoli H, Huang Y, Dulencin A, Matteson P, Cornacchia M, et al. Identification of a schizophrenia-associated functional noncoding variant in NOS1AP. Am. J. Psychiatry. 2009;166:434–441

PII: S0920-9964(10)01371-X

doi: 10.1016/j.schres.2010.06.014

Schizophrenia Research
Volume 122, Issue 1 , Pages 81-84 , September 2010

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