Schizophrenia Research
Volume 122, Issue 1 , Pages 85-93 , September 2010

Executive function in deficit schizophrenia: What do the dimensions of the Wisconsin Card Sorting Test tell us?

  • P. Polgár

      Affiliations

    • Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
    • Corresponding Author InformationCorresponding author. 1083 Budapest, Balassa u, 6, Hungary. Tel.: +36 1 2100330; fax: +36 1 2100336.
    • ,
  • J.M. Réthelyi

      Affiliations

    • Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
    • ,
  • S. Bálint

      Affiliations

    • Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
    • ,
  • S. Komlósi

      Affiliations

    • Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
    • ,
  • P. Czobor

      Affiliations

    • Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
    • Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    • ,
  • I. Bitter

      Affiliations

    • Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary

Received 28 April 2009 ,Accepted 14 June 2010.

References 

  1. American Psychiatric Association . DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. fourth ed.. Washington, DC: American Psychiatric Association; 1994;
  2. Balázs J, Bitter I, Hideg K, Vitray J. A M.I.N.I. és a M.I.N.I. PLUSZ kérdőív magyar nyelvű változatának kidolgozása. Psychiatr. Hung. 1998;13:160–168
  3. Bell MD, Greig TC, Kaplan E, Bryson G. Wisconsin Card Sorting Test dimensions in schizophrenia: factorial, predictive, and divergent validity. J. Clin. Exp. Neuropsychol. 1997;19(6):933–941
  4. Bowden SC, Fowler KS, Bell RC, et al. The reliability and internal validity of the Wisconsin Card Sorting Test. Neuropsychol. Rehabil. 1998;8:243–254
  5. Bryson G, Whelahan HA, Bell M. Memory and executive function impairments in deficit syndrome schizophrenia. Psychiatry Res. 2001;10(2):29–37
  6. Buchanan RW, Strauss ME, Kirckpatrick B, Holstein C, Breier A, JR Carpenter WT. Neuropsychological impairments in deficit vs nondeficit forms of schizophrenia. Arch. Gen. Psychiatry. 1994;51:804–811
  7. Buchanan RW, Strauss ME, Breier A, Kirkpatrick B, Carpenter WT. Attentional impairments in deficit and nondeficit forms of schizophrenia. Am. J. Psychiatry. 1997;154(3):363–370
  8. Carpenter WT, Heinrich DW, Wagman AM. Deficit and nondeficit forms of schizophrenia: the concept. Am. J. Psychiatry. 1988;145:578–583
  9. Chemerinski E, Reichenberg A, Kirkpatrick B, Bowie CR, Harvey PD. Three dimensions of clinical symptoms in elderly patients with schizophrenia: prediction of six-year cognitive and functional status. Schizophr. Res. 2006;85(1–3):12–19
  10. Cohen AS, Saperstein AM, Gold JM, Kirckpatrick B, Carpenter WT, Buchanan RW. Neuropsychology of the deficit syndrome: new data and meta-analysis of findings to date. Schizophr. Bull. 2007;33:1201–1212
  11. Cuesta MJ, Peralta V, Caro F, de Leon J. Schizophrenic syndrome and Wisconsin Card Sorting Test dimensions. Psychiatry Res. 1995;58(1):45–51
  12. Farkas M, Polgár P, Kelemen O, et al. Associative learning in deficit and nondeficit schizophrenia. NeuroReport. 2008;8;19(1):55–58
  13. Galderisi S, Maj M, Mucci A, et al. Historical, psychopathological, neurological, and neuropsychological aspects of deficit schizophrenia: a multicenter study. Am. J. Psychiatry. 2002;159:983–990
  14. Goldman RS, Axelrod BN, Heaton RK, et al. Latent structure of the WCST with the standardization samples. Assessment. 1996;3:73–78
  15. Green MF. Stimulating the development of drug treatments to improve cognition in schizophrenia. Annu. Rev. Clin. Psychol. 2007;3:159–180
  16. Greve KW, Williams MC, Haas WG, Littell RR, Reinoso C. The role of attention in Wisconsin Card Sorting Test performance. Arch. Clin. Neuropsychol. 1996;11:215–222
  17. Greve KW, Brooks J, Crouch JA, Williams MC, Rice WJ. Factorial structure of the Wisconsin Card Sorting Test. Br. J. Clin. Psychol. 1997;36(Pt 2):283–285
  18. Greve KW, Ingram F, Bianchini KJ. Latent Structure of the Wisconsin Card Sorting Test in a Clinical Sample. Arch. Clin. Neuropsychol. 1998;Vol. 13(7):597–609
  19. Greve KW, Bianchini KJ, Hartley SM, Adams D. The Wisconsin Card Sorting Test in stroke rehabilitation: factor structure and relationship to outcome. Arch. Clin. Neuropsychol. 1999;14:497–509
  20. Greve KW, Love JM, Sherwin E, Mathias CW, Ramzinski P, Levy J. Wisconsin Card Sorting Test in chronic severe traumatic brain injury: factor structure and performance subgroups. Brain Inj. 2002;16:29–40
  21. Greve KW, Stickle TR, Love JM, Bianchini KJ, Stanford MS. Latent structure of the Wisconsin Card Sorting Test: a confirmatory factor analytic study. Arch. Clin. Neuropsychol. 2005;20, 3:355–364
  22. Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G. Wisconsin Card Sorting Test Manual Revised and expanded. USA: Psychological Assassment Resources; 1993;
  23. Heckers S, Goff D, Schacter DL, Savage CR, Fischman AJ, Alpert NM, et al. Functional imaging of memory retrieval in deficit vs nondeficit schizophrenia. Arch. Gen. Psychiatry. 1999;56(12):1117–1123
  24. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 1987;13:261–276
  25. Kirckpatrick B, Buchanan RW, McKenney PD, Alphs LD, JR Carpenter WT. The Schedule for the Deficit syndrome: an instrument for research in schizophrenia. Psychiatry Res. 1989;30:119–123
  26. Kirkpatrick B, Buchanan RW, Ross DE, Carpenter WT. A separate disease within the syndrome of schizophrenia. Arch. Gen. Psychiatry. 2001;58:165–171
  27. Kizilbash A, Donders J. Latent structure of theWisconsin Card Sorting Test after pediatric traumatic head injury. Child Neuropsychol. 1999;5:224–229
  28. Koren D, Seidman LJ, Harrison RH, et al. Factor structure of the Wisconsin Card Sorting Test: dimensions of deficit in schizophrenia. Neuropsychology. 1998;12(2):289–302
  29. Lahti AC, Holcomb HH, Medoff DR, Weiler MA, Tamminga CA, Carpenter WT. Abnormal patterns of regional cerebral blood flow in schizophrenia with primary negative symptoms during an effortful auditory recognition task. Am. J. Psychiatry. 2001;158:1797
  30. Lin CCH, Chen WJ, Yang H-J, Hsiao CK, Tien AY. Performance on the Wisconsin Card Sorting Test among adolescents in Taiwan: norms, factorial structure, and relation to schizotypy. J. Clin. Exp. Neuropsychol. 2000;22:69–79
  31. Paolo AM, Troster AI, Axelrod BN, Koller WC. Construct validity of the WCST in normal elderly and persons with Parkinson's disease. Arch. Clin. Neuropsychol. 1995;10:463–473
  32. Polgár P, Farkas M, Nagy O, et al. How to find the way out from four rooms? The learning of “chaining” associations may shed light on the neuropsychology of the deficit syndrome of schizophrenia. Schizophr. Res. 2008;99(1–3):200–207
  33. Réthelyi JM, Bakker SC, Polgár P, et al. Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010;153B(3):792–801
  34. Rossi A, Arduini L, Daneluzzo E, Bustini M, Prosperini P, Stratta P. Cognitive function in euthymic bipolar patients, stabilized schizophrenic patients, and healthy controls. J. Psychiatry Res. 2000;34:333–339
  35. Somsen RJM, Van der Molen MW, Jennings JR, van Beek B. Wisconsin card sorting in adolescents: analysis of performance, response times and heart rate. Acta Psychol. 2000;104:227–257
  36. Strauss GP, Harrow M, Grossman LS, Rosen C. Periods of Recovery in Deficit Syndrome Schizophrenia: A 20-Year Multi-follow-up Longitudinal Study. Schizophrenia Bulletin. 2008;
  37. Sullivan EV, Mathalon DH, Zipursky RB, Kersteen-Tucker Z, Knight RT, Pfefferbaum A. Factors of the Wisconsin Card Sorting Test as measures of frontal-lobe function in schizophrenia and in chronic alcoholism. Psychiatry Res. 1993;46:175–199
  38. Tamminga CA, Thaker GK, Buchanan R, Kirkpatrick B, Alphs LD, Chase TN, et al. Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch. Gen. Psychiatry. 1992;49:522–530
  39. Wagman AM, Heinrichs DW, Carpenter WT. Deficit and nondeficit forms of schizophrenia: neuropsychological evaluation. Psychiatry Res. 1987;22(4):319–330
  40. Wang X, Shuqiao Y, Kirkpatrick B, Shi C, Jinyao T. Psychopathology and neuropsychological impairments in deficit and nondeficit schizophrenia of Chinese origin. Psychiatry Res. 2008;158:195–205
  41. Wiegner S, Donders J. Performance on the Wisconsin Card Sorting Test after traumatic brain injury. Assessment. 1999;6:179–187

PII: S0920-9964(10)01362-9

doi: 10.1016/j.schres.2010.06.007

Schizophrenia Research
Volume 122, Issue 1 , Pages 85-93 , September 2010

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