Schizophrenia Research
Volume 120, Issue 1 , Pages 63-70 , July 2010

Gray-matter abnormalities in deficit schizophrenia

  • Nicola G. Cascella

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States
    • Corresponding Author InformationCorresponding author. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 North Wolfe Street, Meyer 144, Baltimore, MD 21287, United States. Tel.: +1 410 502 2643.
  • ,
  • Shaina C. Fieldstone

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  • ,
  • Vani A. Rao

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  • ,
  • Godfrey D. Pearlson

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States
    • Olin Neuropsychiatric Research Center, Hartford Hospital Institute of Living, Hartford, CT, United States
    • Yale University School of Medicine, New Haven, CT, United States
  • ,
  • Akira Sawa

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  • ,
  • David J. Schretlen

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States
    • Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Received 29 July 2009 ,Accepted 30 March 2010.

References 

  1. Amador XF, Flaum M, Andreasen NC, Strauss DH, Yale SA, Clark SC, et al. Awareness of illness in schizophrenia and schizoaffective and mood disorders. Arch. Gen. Psychiatry. 1994;51(10):826–836
  2. American Psychiatric Association. American Psychiatric Association. Task Force on DSM-IV . Diagnostic and statistical manual of mental disorders: DSM-IV. American Psychiatric Association: Washington, DC; 1994;
  3. Anderson JE, Wible CG, McCarley RW, Jakab M, Kasai K, Shenton ME. An MRI study of temporal lobe abnormalities and negative symptoms in chronic schizophrenia. Schizophr. Res. 2002;58(2–3):123–134
  4. Andreasen NC, Olsen S. Negative v positive schizophrenia. Definition and validation. Arch. Gen. Psychiatry. 1982;39(7):789–794
  5. Ashburner J, Friston KJ. Voxel-based morphometry-the methods. Neuroimage. 2000;11:805–821
  6. Ashburner J, Friston KJ. Unified segmentation. Neuroimage. 2005;26:839–851
  7. Ballmaier M, Schlagenhauf F, Toga AW, Gallinat J, Koslowski M, Zoli M, et al. Regional patterns and clinical correlates of basal ganglia morphology in non-medicated schizophrenia. Schizophr. Res. 2008;106(2–3):140–147
  8. Becker T, Elmer K, Schneider F, Schneider M, Grodd W, Bartels M, et al. Confirmation of reduced temporal limbic structure volume on magnetic resonance imaging in male patients with schizophrenia. Psychiatry Res. 1996;67(2):135–143
  9. Buchanan RW, Breier A, Kirkpatrick B, Elkashef A, Munson RC, Gellad F, et al. Structural abnormalities in deficit and nondeficit schizophrenia. Am. J. Psychiatry. 1993;150(1):59–65
  10. Carpenter WT, Heinrichs DW, Wagman AM. Deficit and nondeficit forms of schizophrenia: the concept. Am. J. Psychiatry. 1988;145(5):578–583
  11. Cascella NG, Testa SM, Meyer SM, Rao VA, Diaz-Asper CM, Pearlson GD, et al. Neuropsychological impairment in deficit vs. non-deficit schizophrenia. J. Psychiatr. Res. 2008;42(11):930–937
  12. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders — Clinical Version (SCID-CV). Washington, DC: American Psychiatric Press; 1997;
  13. Frederikse M, Lu A, Aylward E, Barta P, Sharma T, Pearlson G. Sex differences in inferior parietal lobule volume in schizophrenia. Am. J. Psychiatry. 2000;157(3):422–427
  14. Galderisi S, Quarantelli M, Volpe U, Mucci A, Cassano GB, Invernizzi G, et al. Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia. Schizophr. Bull. 2008;34(2):393–401
  15. Glahn DC, Laird AR, Ellison-Wright I, Thelen SM, Robinson JL, Lancaster JL, et al. Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis. Biol. Psychiatry. 2008;64(9):774–781
  16. Honea R, Crow TJ, Passingham D, Mackay CE. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am. J. Psychiatry. 2005;162(12):2233–2245
  17. Hulshoff Pol HE, Schnack HG, Mandl RC, van Haren NE, Koning H, Collins DL, et al. Focal gray matter density changes in schizophrenia. Arch. Gen. Psychiatry. 2001;58(12):1118–1125
  18. Kirkpatrick B, Buchanan RW, McKenney PD, Alphs LD, Carpenter WT. The Schedule for the Deficit syndrome: an instrument for research in schizophrenia. Psychiatry Res. 1989;30(2):119–123
  19. Kirkpatrick B, Castle D, Murray RM, Carpenter WT. Risk factors for the deficit syndrome of schizophrenia. Schizophr. Bull. 2000;26(1):233–264
  20. Laird AR, Fox PM, Price CJ, Glahn DC, Uecker AM, Lancaster JL, et al. ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts. Hum. Brain Mapp. 2005;25(1):155–164
  21. Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, et al. Automated Talairach atlas labels for functional brain mapping. Hum. Brain Mapp. 2000;10(3):120–131
  22. Lancaster JL, Tordesillas-Gutierrez D, Martinez M, Salinas F, Evans A, Zilles K, et al. Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template. Hum. Brain Mapp. 2007;28(11):1194–1205
  23. Lehericy S, Ducros M, Van de Moortele PF, Francois C, Thivard L, Poupon C, et al. Diffusion tensor fiber tracking shows distinct corticostriatal circuits in humans. Ann. Neurol. 2004;55(4):522–529
  24. Lui S, Deng W, Huang X, Jiang L, Ma X, Chen H, et al. Association of cerebral deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study. Am. J. Psychiatry. 2009;166(2):196–205
  25. Matsumoto H, Simmons A, Williams S, Hadjulis M, Pipe R, Murray R, et al. Superior temporal gyrus abnormalities in early-onset schizophrenia: similarities and differences with adult-onset schizophrenia. Am. J. Psychiatry. 2001;158(8):1299–1304
  26. Nestor PG, Onitsuka T, Gurrera RJ, Niznikiewicz M, Frumin M, Shenton ME, et al. Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia. Schizophr. Res. 2007;91(1–3):103–106
  27. Nurnberger JI, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch. Gen. Psychiatry. 1994;51(11):849–859(discussion 863-844)
  28. Park KM, Kim JJ, Ku J, Kim SY, Lee HR, Kim SI, et al. Neural basis of attributional style in schizophrenia. Neurosci. Lett. 2009;459(1):35–40
  29. Quarantelli M, Larobina M, Volpe U, Amati G, Tedeschi E, Ciarmiello A, et al. Stereotaxy-based regional brain volumetry applied to segmented MRI: validation and results in deficit and nondeficit schizophrenia. Neuroimage. 2002;17(1):373–384
  30. Sanfilipo M, Lafargue T, Rusinek H, Arena L, Loneragan C, Lautin A, et al. Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms. Arch. Gen. Psychiatry. 2000;57(5):471–480
  31. Saugstad LF. What is a psychosis and where is it located?. Eur. Arch. Psychiatry Clin. Neurosci. 2008;258(Suppl 2):111–117
  32. Schretlen DJ, Winicki JM, Meyer SM, Testa SM, Pearlson GD, Gordon B. Development, psychometric properties, and validity of the Hopkins Adult Reading Test (HART). Clin. Neuropsychol. 2009;23(6):926–943
  33. Sigmundsson T, Suckling J, Maier M, Williams S, Bullmore E, Greenwood K, et al. Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am. J. Psychiatry. 2001;158(2):234–243
  34. Turetsky B, Cowell PE, Gur RC, Grossman RI, Shtasel DL, Gur RE. Frontal and temporal lobe brain volumes in schizophrenia. Relationship to symptoms and clinical subtype. Arch. Gen. Psychiatry. 1995;52(12):1061–1070
  35. Wing JK, Sartorius N, Ustun TB. Schedules for Clinical Assessment in Neuropsychiatry (SCAN) Version 2.1. Geneva: World Health Organization; 1996;
  36. Wright IC, McGuire PK, Poline JB, Travere JM, Murray RM, Frith CD, et al. A voxel-based method for the statistical analysis of gray and white matter density applied to schizophrenia. Neuroimage. 1995;2(4):244–252

PII: S0920-9964(10)01219-3

doi: 10.1016/j.schres.2010.03.039

Schizophrenia Research
Volume 120, Issue 1 , Pages 63-70 , July 2010