Schizophrenia Research
Volume 118, Issue 1 , Pages 6-11 , May 2010

Deconstructing processing speed deficits in schizophrenia: Application of a parametric digit symbol coding test

  • Peter Bachman

      Affiliations

    • Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA
    • ,
  • Abraham Reichenberg

      Affiliations

    • Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
    • ,
  • Patrick Rice

      Affiliations

    • Research Imaging Center, University of Texas Health Science Center San Antonio, San Antonio, TX, 78284, USA
    • ,
  • Mary Woolsey

      Affiliations

    • Research Imaging Center, University of Texas Health Science Center San Antonio, San Antonio, TX, 78284, USA
    • ,
  • Olga Chaves

      Affiliations

    • Research Imaging Center, University of Texas Health Science Center San Antonio, San Antonio, TX, 78284, USA
    • ,
  • David Martinez

      Affiliations

    • Research Imaging Center, University of Texas Health Science Center San Antonio, San Antonio, TX, 78284, USA
    • ,
  • Natalie Maples

      Affiliations

    • Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, 78284, USA
    • ,
  • Dawn I. Velligan

      Affiliations

    • Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, 78284, USA
    • ,
  • David C. Glahn

      Affiliations

    • Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, 200 Retreat Avenue, CT, 06106, USA
    • Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT, 06511, USA
    • Corresponding Author InformationCorresponding author. Olin Neuropsychiatry Research Center, Whitehall Research Building, Institute of Living, 200 Retreat Ave, Hartford, CT 06106, USA. Tel.: +1 860 545 7298 (Office); fax: +1 860 545 7797.

Received 7 December 2009 ,Revised 3 February 2010 ,Accepted 5 February 2010.

References 

  1. Brekke JS, Raine A, Ansel M, Lencz T, Bird L. Neuropsychological and psychophysiological correlates of psychosocial functioning in schizophrenia. Schizophr. Bull. 1997;23(1):19–28
  2. Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D, et al. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am. J. Hum. Genet. 2000;67(2):369–382
  3. Chapman LJ, Chapman JP. Disordered Thought in Schizophrenia. xi. New York: Appleton-Century-Crofts; 1973;359pp
  4. Dawson ME, Nuechterlein KH. Psychophysiological dysfunctions in the developmental course of schizophrenic disorders. Schizophr. Bull. 1984;10(2):204–232
  5. Dickinson D. Digit symbol coding and general cognitive ability in schizophrenia: worth another look?. Br. J. Psychiatry. 2008;193(5):354–356
  6. Dickinson D, Ragland JD, Gold JM, Gur RC. General and specific cognitive deficits in schizophrenia: Goliath defeats David?. Biol. Psychiatry. 2008;64(9):823–827
  7. Dickinson D, Ramsey ME, Gold JM. Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. Arch. Gen. Psychiatry. 2007;64(5):532–542
  8. First M.G., Spitzer R.L., Gibbon M., Williams J.B.W. 1998a. Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Non-Patient Edition. New York: Biometrics Research Department, New York State Psychiatric Institute
  9. First M.G., Spitzer R.L., Gibbon M., Williams J.B.W. 1998b. Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Patient Edition. New York: Biometrics Research Department, New York State Psychiatric Institute
  10. Glahn DC, Almasy L, Blangero J, Burk GM, Estrada J, Peralta JM, et al Adjudicating neurocognitive endophenotypes for schizophrenia. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2007;144B(2):242–249
  11. Glahn DC, Ragland JD, Abramoff A, Barrett J, Laird AR, Bearden CE, et al. Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Hum. Brain Mapp. 2005;25(1):60–69
  12. Gold JM, Goldberg RW, McNary SW, Dixon LB, Lehman AF. Cognitive correlates of job tenure among patients with severe mental illness. Am. J. Psychiatry. 2002;159:1395–1402
  13. Jogems-Kosterman BJ, Zitman FG, Van Hoof JJ, Hulstijn W. Psychomotor slowing and planning deficits in schizophrenia. Schizophr. Res. 2001;48(2–3):317–333
  14. Jonides J, Nee DE. Assessing dysfunction using refined cognitive methods. Schizophr. Bull. 2005;31(4):823–829
  15. Joy S, Fein D, Kaplan E. Decoding digit symbol: speed, memory, and visual scanning. Assessment. 2003;10(1):56–65
  16. Joy S, Kaplan E, Fein D. Speed and memory in the WAIS-III Digit Symbol-Coding subtest across the adult lifespan. Arch. Clin. Neuropsychol. 2004;19(6):759–767
  17. King HE. Psychomotor dysfunction in schizophrenia. In:  Steinhauer SR,  Gruzelier JH,  Zubin J editor. Neuropsychology, Psychophysiology and Information Processing Handbook of Schizophrenia, vol. 5. Amsterdam: Elsevier; 1991;p. 273–301
  18. Lee KH, Williams LM. Eye movement dysfunction as a biological marker of risk for schizophrenia. Aust. NZ J. Psychiatry. 2000;34:S91–S100Suppl
  19. Leeson VC, Barnes TR, Harrison M, Matheson E, Harrison I, Mutsatsa SH, et al. The relationship between IQ, memory, executive function, and processing speed in recent-onset psychosis: 1-year stability and clinical outcome. Schizophr. Bull. 2008;
  20. Mahurin RK, Velligan DI, Miller AL. Executive-frontal lobe cognitive dysfunction in schizophrenia: a symptom subtype analysis. Psychiatry Res. 1998;79(2):139–149
  21. Minzenberg MJ, Laird AR, Thelen S, Carter CS, Glahn DC. Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch. Gen. Psychiatry. 2009;66(8):811–822
  22. Mohamed S, Paulsen JS, O'Leary D, Arndt S, Andreasen N. Generalized cognitive deficits in schizophrenia: a study of first-episode patients. Arch. Gen. Psychiatry. 1999;56(8):749–754
  23. Morrens M, Hulstijn W, Matton C, Madani Y, van Bouwel L, Peuskens J, et al. Delineating psychomotor slowing from reduced processing speed in schizophrenia. Cognit. Neuropsychiatry. 2008;13(6):457–471
  24. Morrens M, Hulstijn W, Sabbe B. Psychomotor slowing in schizophrenia. Schizophr. Bull. 2007;33(4):1038–1053
  25. Morrens M, Hulstijn W, Van Hecke J, Peuskens J, Sabbe BG. Sensorimotor and cognitive slowing in schizophrenia as measured by the Symbol Digit Substitution Test. J. Psychiatr. Res. 2006;40(3):200–206
  26. Niendam TA, Bearden CE, Rosso IM, Sanchez LE, Hadley T, Nuechterlein KH, et al. A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. Am. J. Psychiatry. 2003;160(11):2060–2062
  27. Nuechterlein KH. Reaction time and attention in schizophrenia: a critical evaluation of the data and theories. Schizophr. Bull. 1977;3(3):373–428
  28. Roach BJ, Mathalon DH. Event-related EEG time-frequency analysis: an overview of measures and an analysis of early gamma band phase locking in schizophrenia. Schizophr. Bull. 2008;34(5):907–926
  29. Salthouse TA. General and specific speed mediation of adult age differences in memory. J. Gerontol. B. Psychol. Sci. Soc. Sci. 1996;51(1):P30–P42
  30. Salthouse TA. The processing-speed theory of adult age differences in cognition. Psychol. Rev. 1996;103(3):403–428
  31. Saykin AJ, Shtasel DL, Gur RE, Kester DB, Mozley LH, Stafiniak P, et al. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch. Gen. Psychiatry. 1994;51(2):124–131
  32. Stephan KE, Friston KJ, Frith CD. Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring. Schizophr. Bull. 2009;35(3):509–527
  33. Thaker GK. Neurophysiological endophenotypes across bipolar and schizophrenia psychosis. Schizophr. Bull. 2008;34(4):760–773
  34. van Erp TG, Lesh TA, Knowlton BJ, Bearden CE, Hardt M, Karlsgodt KH, et al Remember and know judgments during recognition in chronic schizophrenia. Schizophr. Res. 2008;100(1–3):181–190
  35. Velligan D, Prihoda T, Dennehy E, Biggs M, Shores-Wilson K, Crismon ML, et al Brief psychiatric rating scale expanded version: how do new items affect factor structure?. Psychiatry Res. 2005;135(3):217–228
  36. Ventura J, Lukoff D, Nuechterlein KH, Liberman RP, Green MF, Shaner A. Manual for the expanded Brief Psychiatric Rating Scale. Int. J. Methods. Psychiatr. Res. 1993;3:227–244
  37. Wechsler D. Wechsler Adult Intelligence Scale-Third Edition. San Antonio, Texas: The Psychological Corporation; 1997;

PII: S0920-9964(10)01115-1

doi: 10.1016/j.schres.2010.02.1029

Schizophrenia Research
Volume 118, Issue 1 , Pages 6-11 , May 2010

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