Schizophrenia Research
Volume 118, Issue 1 , Pages 256-263 , May 2010

Rate and predictors of service disengagement in an epidemiological first-episode psychosis cohort

  • Philippe Conus

      Affiliations

    • Treatment and Early Intervention in Psychosis Program (TIPP), Département Universitaire de Psychiatrie Adulte, Université de Lausanne, Clinique de Cery, Switzerland
    • Orygen Youth Health and Research Centre, Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia
    • Corresponding Author InformationCorresponding author. Département Psychiatrie CHUV, Teatment and Early Intervention in Psychosis Program (TIPP), Clinique de Cery, 1008 Prilly, Switzerland. Tel.: +41 21 643 61 11; fax: +41 21 643 64 69.
  • ,
  • Martin Lambert

      Affiliations

    • Psychosis Early Detection and Intervention Centre (PEDIC), Centre for Psychosocial Medicine, Department for Psychiatry and Psychotherapy, University Medical Centre Hamburg-Eppendorf, Germany
  • ,
  • Sue Cotton

      Affiliations

    • Orygen Youth Health and Research Centre, Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia
  • ,
  • Charles Bonsack

      Affiliations

    • Treatment and Early Intervention in Psychosis Program (TIPP), Département Universitaire de Psychiatrie Adulte, Université de Lausanne, Clinique de Cery, Switzerland
  • ,
  • Patrick D McGorry

      Affiliations

    • Orygen Youth Health and Research Centre, Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia
  • ,
  • Benno G Schimmelmann

      Affiliations

    • Child and Adolescent Psychiatry, University of Bern, Switzerland

Received 29 October 2009 ,Revised 13 January 2010 ,Accepted 29 January 2010.

References 

  1. Alvarez-Jimenez M, Gleeson JF, Cotton SM, Wade D, Crisp K, Yap MBH, et al. Differential predictors of critical comments and emotional over-involvement in first-episode psychosis. Psychol. Med. 2010;40:63–72
  2. APA, American Psychiatric Association. Diagnostic Criteria from DSM-IV. Washington.: American Psychiatric Press; 1994;
  3. Bonsack C, Adam L, Haefliger T, Besson J, Conus P. “Difficult-to-engage” patients: a specific target for time limited assertive outreach in a Swiss setting. Can. J. Psychiatry. 2005;50:845–850
  4. Bonsack C, Pfister T, Conus P. Insertion dans les soins après une première hospitalisation dans un secteur pour une psychose. Encéphale. 2006;32:679–685
  5. Conus P, Cotton S, Schimmelmann BG, McGorry PD, Lambert M. The First-Episode Psychosis Outcome Study: premorbid and baseline characteristics of an epidemiological cohort of 661 first-episode psychosis patients. Early Interv Psychiatry. 2007;1:191–200
  6. Conus P, Cotton S, Schimmelmann BG, McGorry PD, Lambert M. Pre-treatment and outcome correlates of sexual and physical trauma in an epidemiological cohort of first episode psychosis patients. Schizophr Bull. 2009;Apr 21, Epub ahead of print
  7. Cox DR, Snell DJ. In: The Analysis of Binary Data. 2nd edition. London: Chapman & Hall; 1989;
  8. Craig TK, Garety P, Power P, Rahaman N, Colbert S, Fornells-Ambrojo M, et al. The Lambeth early onset (LEO) team: randomised controlled trial of the effectiveness of specialised care for early psychosis. Br Med J. 2004;329:1067
  9. Edwards J, McGorry PD. Implementing Early Intervention in Psychosis. London, England: Martin Dunitz Publisher; 2002;
  10. EPPIC. Australian Clinical Guidelines for Early Psychosis. National Early Psychosis Project. Melbourne.: University of Melbourne; 1998;
  11. Garety PA, Criag TK, Dunn G, Fornells-Ambrojo M, Colbert S, Rahaman N, et al. Specialised care for early psychosis: symptoms, social functioning and patient satisfaction: randomised controlled trial. Br. J. Psychiatry. 2006;188:37–45
  12. Guy W. ECDEU Assessment Manual for Psychopharmacology, revised. US Dept Health, Education, and Welfare publication (ADM) 76-338. In: Riockville Md: National Institute of mental Health. 1976;p. 218–222
  13. Lambert M, Conus P, Lubmann DI, Wade D, Yuen HP, Eide P, et al. The impact of substance abuse disorder on clinical outcome in 643 patients with first episode psychosis. Acta Psychiatr. Scand. 2005;112:141–148
  14. Lecomte T, Spidel A, Leclerc C, William MacEwan G, Greaves C, Bentall RP. Predictors and profiles of treatment non-adherence and engagement in services problems in early psychosis. Schizophr. Res. 2008;102:295–302
  15. Malla AM, Norman RM. Treating psychosis: is there more to early intervention than intervening early?. Can. J. Psychiatry. 2001;46(7):645–648
  16. Marshall M, Lewis S, Lockwood A, Drake R, Jones P, Croudace T. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients. Arch. Gen. Psychiatry. 2005;62:975–983
  17. McGlashan TH, Wadeson HS, Carpenter WT, Levy ST. Art and recovery style from psychosis. J Nerv Ment Dis. 1977;164:182–190
  18. McGorry PD, Copolov DL, Singh BS. Royal Park Multidiagnostic Instrument for Psychosis: Part I. Rationale and review. Schizophr Bul. 1990;16:501–515
  19. McGorry PD, Singh BS, Copolov D, Kaplan I, Dossetor CR, Van Riel RJ. Royal Park Multidiagnostic Instrument for Psychosis: Part II. Development, reliability, and validity. Schizophr. Bull. 1990;16:517–536
  20. Melle I, Larsen TK, Haahr U, Friis S, Johannessen JO, Opjordsmoen S, et al. Reducing the duration of untreated first-episode psychosis: effects on clinical presentation. Arch. Gen. Psychiatry. 2004;61:143–150
  21. Petersen L, Jeppesen P, Thorup A, Abel MB, Ohlenschlaeger J, Christensen TO, et al. A randomised multi-centre trial of integrated versus standard treatment for patients with a first episode of psychotic illness. BMJ. 2005;331:602
  22. Polari A, Macneil C, Berk M, Conus P. Duration of untreated psychosis — what are we talking about?. Acta Neuropsychiatr. 2009;3:106–108
  23. Schimmellmann B, Conus P, Edwards J, McGorry PD, Lambert M. Diagnostic stability after a first diagnosis of psychosis. J Clin Psychiatry. 2005;66:1239–1246
  24. Schimmelmann B, Huber C, Lambert M, Cotton S, McGorry P, Conus P. Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort. J Psychiatric Res. 2008;42:982–990
  25. Schimmelmann BG, Conus P, Cotton S, McGorry PD, Lambert M. Pre-treatment, baseline and outcome differences between early-onset and adult-onset psychosis in an epidemiological cohort of 636 first-episode patients. Schizophr. Res. 2007;95:1–8
  26. Schimmelmann BG, Conus P, Schacht M, McGorry PD, Lambert M. Predictors of service disengagement in first admitted adolescents with psychosis. J Amer Acad Child Adol Psychiatry. 2006;45(8):990–999
  27. Tabachnick BG, Fidell LS. Using Multivariate Statistics. In: 4th edition. Needham Heights: MA, Allyn & Bacon; 2001;
  28. Tait L, Birchwood M, Trower P. Predicting engagement with services for psychosis: insight, symptoms and recovery style. Br. J. Psychiatry. 2003;182:123–128
  29. Tohen M, Strakowski SM, Zarate C, Hennen J, Stoll AL, Suppes T, et al. The McLean–Harvard first-episode project: 6-month symptomatic and functional outcome in affective and nonaffective psychosis. Biol. Psychiatry. 2000;48:467–476
  30. Turner M, Smith-Hamel C, Mulder R. Prediction of twelve-month service disengagement from an early intervention in psychosis service. Early Interv Psychiatry. 2007;1:276–281
  31. Ventura J, Liberman RP, Green MF, Shaner A, Mintz J. Training and quality assurance with the Structured Clinical Interview for DSM-IV (SCID I/P). Psychiatry Res. 1998;79:163–173
  32. Yung AR, Phillips LJ, McGorry PD, McFarlane CA, Francey S, Harrigan S, et al. Prediction of psychosis: a step towards indicated prevention of schizophrenia. Br. J. Psychiatry Suppl. 1998;172:14–20

PII: S0920-9964(10)00085-X

doi: 10.1016/j.schres.2010.01.032

Schizophrenia Research
Volume 118, Issue 1 , Pages 256-263 , May 2010