Schizophrenia Research
Volume 118, Issue 1 , Pages 300-302 , May 2010

No association between DAO and schizophrenia in a Japanese patient population: A multicenter replication study

  • Tohru Ohnuma

      Affiliations

    • Juntendo University Schizophrenia Projects (JUSP), Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
    • Corresponding Author InformationCorresponding author. Tel./fax: +81 35802 1071.
    • ,
  • Nobuto Shibata

      Affiliations

    • Juntendo University Schizophrenia Projects (JUSP), Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
    • ,
  • Hajime Baba

      Affiliations

    • Juntendo University Schizophrenia Projects (JUSP), Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
    • ,
  • Kazutaka Ohi

      Affiliations

    • Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    • ,
  • Yuka Yasuda

      Affiliations

    • Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    • The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    • ,
  • Yukako Nakamura

      Affiliations

    • Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    • ,
  • Tomo Okochi

      Affiliations

    • Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    • ,
  • Hiroshi Naitoh

      Affiliations

    • Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    • ,
  • Ryota Hashimoto

      Affiliations

    • Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    • The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    • ,
  • Nakao Iwata

      Affiliations

    • Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    • ,
  • Norio Ozaki

      Affiliations

    • Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    • ,
  • Masatoshi Takeda

      Affiliations

    • Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    • The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    • ,
  • Heii Arai

      Affiliations

    • Juntendo University Schizophrenia Projects (JUSP), Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

Received 6 October 2009 ,Revised 13 January 2010 ,Accepted 29 January 2010.

References 

  1. Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat. Genet. 2008;40:827–834
  2. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, et al. Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A. 2002;99:13675–13680
  3. Corvin A, McGhee KA, Murphy K, Donohoe G, Nangle JM, Schwaiger S, et al. Evidence for association and epistasis at the DAOA/G30 and d-amino acid oxidase loci in an Irish schizophrenia sample. Am J Med Genet B Neuropsychiatr Genet. 2007;144:949–953
  4. Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA, et al. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am. J. Hum. Genet. 2005;77:918–936
  5. Jonsson EG, Saetre P, Vares M, Andreou D, Larsson K, Timm S, et al. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. Neuropsychobiology. 2009;59:142–150
  6. Liu YL, Fann CS, Liu CM, Chang CC, Wu JY, Hung SI, et al. No association of G72 and d-amino acid oxidase genes with schizophrenia. Schizophr. Res. 2006;87:15–20
  7. Ohnuma T, Shibata N, Maeshima H, Baba H, Hatano T, Hanzawa R, et al. Association analysis of glycine- and serine-related genes in a Japanese population of patients with schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2009;33:511–518
  8. Schumacher J, Jamra RA, Freudenberg J, Becker T, Ohlraun S, Otte AC, et al. Examination of G72 and d-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry. 2004;9:203–207
  9. Shi J, Gershon ES, Liu C. Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophr. Res. 2008;104:96–107
  10. Shinkai T, De Luca V, Hwang R, Muller DJ, Lanktree M, Zai G, et al. Association analyses of the DAOA/G30 and d-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia. Neuromolecular Med. 2007;9:169–177
  11. Tsai G, Yang P, Chung LC, Lange N, Coyle JT. d-serine added to antipsychotics for the treatment of schizophrenia. Biol. Psychiatry. 1998;44:1081–1089
  12. Verrall L, Burnet PW, Betts JF, Harrison PJ. The neurobiology of d-amino acid oxidase and its involvement in schizophrenia. Mol Psychiatry. 2009;29:1–16
  13. Vilella E, Costas J, Sanjuan J, Guitart M, De Diego Y, Carracedo A, et al. Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction. J Psychiatr Res. 2008;42:278–288
  14. Wood LS, Pickering EH, Dechairo BM. Significant support for DAO as a schizophrenia susceptibility locus: examination of five genes putatively associated with schizophrenia. Biol. Psychiatry. 2007;61:1195–1199
  15. Yamada K, Ohnishi T, Hashimoto K, Ohba H, Iwayama-Shigeno Y, Toyoshima M, et al. Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and d-serine levels. Biol. Psychiatry. 2005;57:1493–1503

PII: S0920-9964(10)00080-0

doi: 10.1016/j.schres.2010.01.028

Schizophrenia Research
Volume 118, Issue 1 , Pages 300-302 , May 2010

Article Tools