Schizophrenia Research
Volume 118, Issue 1 , Pages 232-239 , May 2010

Grey matter changes associated with host genetic variation and exposure to Herpes Simplex Virus 1 (HSV1) in first episode schizophrenia

  • Konasale M. Prasad

      Affiliations

    • University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    • Corresponding Author InformationCorresponding author.
  • ,
  • Mikhil N. Bamne

      Affiliations

    • University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
  • ,
  • Brian H. Shirts

      Affiliations

    • University of Utah School of Medicine, Salt Lake City, UT, United States
  • ,
  • Dhruman Goradia

      Affiliations

    • University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
  • ,
  • Vimal Mannali

      Affiliations

    • University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
  • ,
  • Krishna M. Pancholi

      Affiliations

    • University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
  • ,
  • Bai Xue

      Affiliations

    • University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
  • ,
  • Lora McClain

      Affiliations

    • University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
  • ,
  • Robert H. Yolken

      Affiliations

    • Stanley Division of Developmental Neurovirology, Johns Hopkins School of Medicine, Baltimore, MD, United States
  • ,
  • Matcheri S. Keshavan

      Affiliations

    • University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    • Harvard Medical School, Boston, MA, United States
  • ,
  • Vishwajit L. Nimgaonkar

      Affiliations

    • University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States

Received 6 November 2009 ,Revised 31 December 2009 ,Accepted 4 January 2010.

References 

  1. American Psychiatric Association . Diagnostic & Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association; 1994;
  2. Ashley RL. Genital herpes. Type-specific antibodies for diagnosis and management. Dermatol. Clin. 1998;16(4):789–793xiii–xiv
  3. Brett M, Anton J, Valabregue R, Poline J. Region of Interest Analysis Using an SPM Toolbox. In: 8th International Conference on Functional Mapping of the Human Brain, Sendai, Japan. 2002;
  4. Cleator GM, Klapper PE. Herpes Simplex. In:  Zuckerman AJ,  Banatvala JE,  Pattison JR editor. Principles and Practice of Clinical Virology. New York: John Wiley and Sons, Ltd; 2004;p. 27–51
  5. Cleator GM, Klapper PE. The Herpesviridae. In:  Zuckerman AJ,  Banatvala JE,  Pattison JR editor. Principles and Practice of Clinical Virology. New York: John Wiley & Sons, Ltd; 2004;p. 23–26
  6. Dickerson FB, Boronow JJ, Stallings C, Origoni AE, Ruslanova I, Yolken RH. Association of serum antibodies to herpes simplex virus 1 with cognitive deficits in individuals with schizophrenia. Arch. Gen. Psychiatry. 2003;60(5):466–472
  7. Dickerson F, Stallings C, Sullens A, Origoni A, Leister F, Krivogorsky B, et al. Association between cognitive functioning, exposure to Herpes Simplex Virus type 1, and the COMT Val158Met genetic polymorphism in adults without a psychiatric disorder. Brain, Behav., Immun. 2008;22:1103–1107
  8. First MB. The Structured Clinical Interview for DSM-IV for Axis I Disorders: Clinical Version, Administration Booklet. Washington, DC: American Psychiatric Press; 1997;
  9. Gilbert AR, Rosenberg DR, Harenski K, Spencer S, Sweeney JA, Keshavan MS. Thalamic volumes in patients with first-episode schizophrenia. Am. J. Psychiatry. 2001;158(4):618–624
  10. Gitelman DR, Ashburner J, Friston KJ, Tyler LK, Price CJ. Voxel-based morphometry of Herpes Simplex Encephalitis. NeuroImage. 2001;13(4):623–631
  11. Hollingshead AB. Four-factor Index of Social Status. New Haven, CT: Yale University; 1975;
  12. Kim JJ, Shirts BH, Dayal M, Bacanu SA, Wood J, Xie W, et al. Are exposure to cytomegalovirus and genetic variation on chromosome 6p joint risk factors for schizophrenia?. Ann. Med. 2007;39(2):145–153
  13. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage. 2003;19(3):1233–1239
  14. Mathworks Inc . Matlab. Natick, MA: Mathworks Inc; 2002;
  15. Minzenberg MJ, Laird AR, Thelen S, Carter CS, Glahn DC. Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch. Gen. Psychiatry. 2009;66(8):811–822
  16. NHANES II . Second National Health and Nutrition Examination Survey 1976–1980. CDC, Center for Disease Control and Prevention. 2007;
  17. Prasad KM, Shirts BH, Yolken RH, Keshavan MS, Nimgaonkar VL. Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia. Mol. Psychiatry. 2007;12(1):105–1131
  18. Schillinger JA, Xu F, Sternberg MR, Armstrong GL, Lee FK, Nahmias AJ, et al. National seroprevalence and trends in herpes simplex virus type 1 in the United States, 1976–1994. Sex. Transm. Dis. 2004;31(12):753–760
  19. Shirts BH, Kim JJ, Reich S, Dickerson FB, Yolken RH, Devlin B, et al. Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk. Schizophr. Res. 2007;94(1–3):342–353
  20. Shirts BH, Prasad KM, Pogue-Geile MF, Dickerson F, Yolken RH, Nimgaonkar VL. Antibodies to cytomegalovirus and Herpes Simplex Virus 1 associated with cognitive function in schizophrenia. Schizophr. Res. 2008;106(2–3):268–274
  21. Shirts BH, Wood J, Yolken RH, Nimgaonkar VL. Comprehensive evaluation of positional candidates in the IL-18 pathway reveals suggestive associations with schizophrenia and herpes virus seropositivity. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008;147(3):343–350
  22. SPSS. Statistical Package for Social Sciences, Ver 16, Illinois, Chicago. 2005;
  23. Vartiainen N, Kallio-Laine K, Hlushchuk Y, Kirveskari E, Seppanen M, Autti H, et al. Changes in brain function and morphology in patients with recurring herpes simplex virus infections and chronic pain. Pain. 2009;144(1–2):200–208
  24. Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry. 1986;43(2):114–124
  25. Xu F, Sternberg MR, Kottiri BJ, McQuillan GM, Lee FK, Nahmias AJ, et al. Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA. 2006;296(8):964–973

PII: S0920-9964(10)00045-9

doi: 10.1016/j.schres.2010.01.007

Schizophrenia Research
Volume 118, Issue 1 , Pages 232-239 , May 2010