Schizophrenia Research
Volume 118, Issue 1 , Pages 285-291 , May 2010

Schizophrenia patients with polydipsia and water intoxication are characterized by greater severity of psychotic illness and a more frequent history of alcohol abuse

  • Simon Poirier

      Affiliations

    • Centre de Recherche Universite Laval Robert-Giffard, Beauport, QC, Canada
    • Psychiatry, College of Medicine, Laval University, Québec, QC, Canada
    • Psychiatry, CHUQ, Québec, QC, Canada
    • ,
  • Geneviève Legris

      Affiliations

    • Psychiatry, College of Medicine, Laval University, Québec, QC, Canada
    • Psychiatry, CHUQ, Québec, QC, Canada
    • ,
  • Philippe Tremblay

      Affiliations

    • Psychiatry, College of Medicine, Laval University, Québec, QC, Canada
    • Psychiatry, CHUQ, Québec, QC, Canada
    • ,
  • Rodrigo Michea

      Affiliations

    • Centre de Recherche Universite Laval Robert-Giffard, Beauport, QC, Canada
    • Psychiatry, Hôtel-Dieu de Lévis, Lévis, QC, Canada
    • ,
  • Laurence Viau-Guay

      Affiliations

    • Centre de Recherche Universite Laval Robert-Giffard, Beauport, QC, Canada
    • ,
  • Chantal Mérette

      Affiliations

    • Centre de Recherche Universite Laval Robert-Giffard, Beauport, QC, Canada
    • Psychiatry, College of Medicine, Laval University, Québec, QC, Canada
    • ,
  • Roch-Hugo Bouchard

      Affiliations

    • Centre de Recherche Universite Laval Robert-Giffard, Beauport, QC, Canada
    • Psychiatry, College of Medicine, Laval University, Québec, QC, Canada
    • ,
  • Michel Maziade

      Affiliations

    • Centre de Recherche Universite Laval Robert-Giffard, Beauport, QC, Canada
    • Psychiatry, College of Medicine, Laval University, Québec, QC, Canada
    • ,
  • Marc-André Roy

      Affiliations

    • Centre de Recherche Universite Laval Robert-Giffard, Beauport, QC, Canada
    • Psychiatry, College of Medicine, Laval University, Québec, QC, Canada
    • Corresponding Author InformationCorresponding author. Centre de recherche Université Laval Robert-Giffard, 2601 de la Canardière, Beauport, P. Québec, Canada G1J 2G3. Tel.: +1 418 663 5741; fax: +1 418 663 9540.

Received 18 August 2009 ,Revised 29 December 2009 ,Accepted 30 December 2009.

References 

  1. Addington D, Addington J, Schissel B. A depression rating scale for schizophrenics. Schizophr. Res. 1990;3(4):247–251Jul–Aug
  2. Addington D, Addington J, Atkinson M. A psychometric comparison of the Calgary Depression Scale for Schizophrenia and the Hamilton Depression Rating Scale. Schizophr. Res. 1996;19(2–3):205–212May
  3. Ahmed AG, Heigh LM, Ramachandran KV. Polydipsia, psychosis, and familial psychopathology. Can. J. Psychiatry. 2001;46(6):522–527Aug
  4. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders—Fourth Edition (DSM-IV). Washington D.C.: American Psychiatric Association; 1994;
  5. Andreasen NC, Olsen S. Negative v positive schizophrenia. Definition and validation. Arch. Gen. Psychiatry. 1982;39(7):789–794Jul
  6. Andreasen NC, Flaum M, Arndt S. The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch. Gen. Psychiatry. 1992;49(8):615–623Aug
  7. Bralet MC, Ton T, Falissard B. Schizophrenic patients with polydipsia and water intoxication more often have a form of schizophrenia first described by Kraepelin. Psychiatry Res. 2007;152(2–3):267–271Aug
  8. Brockington I, Roper A, Edmunds E, Kaufman C, Meltzer HY. A longitudinal psychopathological schedule. Psychol. Med. 1992;22(4):1035–1043Nov
  9. Canuso CM, Goldman MB. Clozapine restores water balance in schizophrenic patients with polydipsia–hyponatremia syndrome. J. Neuropsychiatry Clin. Neurosci. 1999;11:86–90
  10. de Leon J. Polydipsia—a study in a long-term psychiatric unit. Eur. Arch. Psychiatry Clin. Neurosci. 2003;253(1):37–39Feb
  11. De Leon J, Verghese C, Tracy JI, Josiassen RC, Simpson GM. Polydipsia and water intoxication in psychiatric patients: a review of the epidemiological literature. Biol. Psychiatry. 1994;35(6):408–419Mar 15
  12. de Leon J, Tracy J, McCann E, McGrory A. Polydipsia and schizophrenia in a psychiatric hospital: a replication study. Schizophr. Res. 2002;57(2–3):293–301Oct 1
  13. Dourish CT. Dopaminergic involvement in the control of drinking behaviour: a brief review. Prog. Neuropsychopharmacol. Biol. Psychiatry. 1983;7(4–6):487–493
  14. Emsley R, Potgieter A, Taljaard F, Joubert G, Gledhill R. Water excretion and plasma vasopressin in psychotic disorders. Am. J. Psychiatry. 1989;146(2):250–253Feb
  15. Fukunaka Y, Shinkai T, Hwang R, Hori H, Utsunomiya K, Sakata S, et al. The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia. Neuromolecular Med. 2007;9(4):292–297
  16. Goldman MB, Luchins DJ, Robertson GL. Mechanisms of altered water metabolism in psychotic patients with polydipsia and hyponatremia. N. Engl. J. Med. 1988;318(7):397–403Feb 18
  17. Goldman MB, Robertson GL, Luchins DJ, Hedeker D, Pandey GN. Psychotic exacerbations and enhanced vasopressin secretion in schizophrenic patients with hyponatremia and polydipsia. Arch. Gen. Psychiatry. 1997;54(5):443–449May
  18. Kane J, Honigfield G, Singer J, et al. Clozapine for the treatment-resistant schizophrenic; a doubleblind comparison with chlorpromazine (clozaril collaborative study). Arch. Gen. Psychiatry. 1988;45:789–796
  19. Kirch DG, Bigelow LB, Weinberger DR, Lawson WB, Wyatt RJ. Polydipsia and chronic hyponatremia in schizophrenic inpatients. J. Clin. Psychiatry. 1985;46(5):179–181May
  20. Lane RM. SSRIs and hyponatremia. Br. J. Clin. Pract. 1997;51(3):144–146Apr–May
  21. Lawrence AJ, Cowen MS, Yang HJ, Chen F, Oldfield B. The orexin system regulates alcohol-seeking in rats. Br. J. Pharmacol. 2006;148(6):752–759Jul
  22. Lehoux C, Everett J, Laplante L, Émond C, Trépanier J, Brassard A, et al. Fine motor dexterity is correlated to social functioning in schizophrenia. Schizophr. Res. 2003;62(3):269–273
  23. Maziade M, Roy MA, Fournier JP, Cliche D, Mérette C, Caron C, et al Reliability of best-estimate diagnosis in genetic linkage studies of major psychoses: results from the Quebec pedigree studies. Am. J. Psychiatry. 1992;149(12):1674–1686Dec
  24. Maziade M, Roy MA, Martinez M, Cliche D, Fournier JP, Garneau Y, et al. Negative, psychoticism, and disorganized dimensions in patients with familial schizophrenia or bipolar disorder: continuity and discontinuity between the major psychoses. Am. J. Psychiatry. 1995;152(10):1458–1463Oct
  25. Maziade M, Bouchard S, Gingras N, Charron L, Cardinal A, Roy MA, et al. Long-term stability of diagnosis and symptom dimensions in a systematic sample of patients with onset of schizophrenia in childhood and early adolescence. II: Postnegative distinction and childhood predictors of adult outcome. Br. J. Psychiatry. 1996;169(3):371–378Sep
  26. Maziade M, Roy MA, Mérette C, Hamel M. Negative and depressive symptoms in bipolar affective disorder. (Letter to the Editor). Am. J. Psychiatry. 1997;154(1):133–134
  27. Meerabux J, Iwayama Y, Sakurai T, Ohba H, Toyota T, Yamada K, et al. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. Biol. Psychiatry. 2005;58(5):401–407Sep 1
  28. Mercier-Guidez E, Loas G. Polydipsia and water intoxication in 353 psychiatric inpatients: an epidemiological and psychopathological study. Eur. Psychiatry. 2000;15(5):306–311Aug
  29. Millson RC, Emes CE, Glackman WG. Self-induced water intoxication treated with risperidone.. Can. J. Psychiatry. 1996;41(10):648–650
  30. Riggs AT, Dysken MW, Kim SW, Opsahl JA. A review of disorders of water homeostasis in psychiatric patients. Psychosomatics. 1991;32:133–148
  31. Ripley TL, Millson RC, Koczapski AB. Self-induced water intoxication and alcohol abuse. Am. J. Psychiatry. 1989;146(1):102–103Jan
  32. Roy MA, Lanctôt G, Mérette C, Cliché D, Fournier JP, Boutin P, et al. Clinical and methodological factors related to reliability of the best-estimate diagnostic procedure. Am. J. Psychiatry. 1997;154(12):1726–1733Dec
  33. Roy MA, Mérette C, Maziade M. Subtyping schizophrenia according to outcome or severity: a search for homogeneous subgroups. A review of the literature. Schizophr. Bull. 2001;27:115–137
  34. Roy MA, Lehoux C, Émond C, Laplante L, Bouchard RH, Everett J, et al. A pilot neuropsychological study of Kraepelinian and non-Kraepelinian schizophrenia. Schizophr. Res. 2003;62:155–163
  35. Shuckit MA, Li T, Cloninger CR, et al. Genetics of alcoholism. Alcoholism (NY). 1985;9:475–492
  36. Sleeper FH. Investigation of polyuria in schizophrenia. Am. J. Psychiatry. 1935;91:1019–1031
  37. Spitzer RL, Williams JB, Gibbon M, First MB. The structured clinical interview for DSM-III-R (SCID). I: History, rationale, and description. Arch. Gen. Psychiatry. 1992;49(8):624–629Aug
  38. Verghese C, De Leon J, Simpson GM. Neuroendocrine factors influencing polydipsia in psychiatric patients: an hypothesis. Neuropsychopharmacology. 1993;9:157–166
  39. Vieweg WV, David JJ, Rowe WT, Peach MJ, Veldhuis JD, Kaiser DL, et al. Psychogenic polydipsia and water intoxication—concepts that have failed. Biol. Psychiatry. 1985;20(12):1308–1320Dec

PII: S0920-9964(10)00003-4

doi: 10.1016/j.schres.2009.12.036

Schizophrenia Research
Volume 118, Issue 1 , Pages 285-291 , May 2010

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