Schizophrenia Research
Volume 116, Issue 2 , Pages 191-195 , February 2010

Later paternal age and sex differences in schizophrenia symptoms

  • Paul J. Rosenfield

      Affiliations

    • Columbia University, College of Physicians and Surgeons, Department of Psychiatry, New York, NY, United States
    • New York State Psychiatric Institute, New York, NY, United States
    • Corresponding Author InformationCorresponding author. 1051 Riverside Drive, New York, NY 10032, Present address: 119W 57th St, Ste 620, New York, NY 10019, United States. Tel.: +1 212 956 6027; fax: +1 212 956 6029.
    • ,
  • Karine Kleinhaus

      Affiliations

    • New York State Psychiatric Institute, New York, NY, United States
    • ,
  • Mark Opler

      Affiliations

    • New York University, School of Medicine, Department of Psychiatry, New York, NY, United States
    • ,
  • Mary Perrin

      Affiliations

    • New York University, School of Medicine, Department of Psychiatry, New York, NY, United States
    • ,
  • Nicole Learned

      Affiliations

    • New York University, School of Medicine, Department of Psychiatry, New York, NY, United States
    • ,
  • Raymond Goetz

      Affiliations

    • Columbia University, College of Physicians and Surgeons, Department of Psychiatry, New York, NY, United States
    • New York State Psychiatric Institute, New York, NY, United States
    • New York University, School of Medicine, Department of Psychiatry, New York, NY, United States
    • ,
  • Arielle Stanford

      Affiliations

    • Columbia University, College of Physicians and Surgeons, Department of Psychiatry, New York, NY, United States
    • New York State Psychiatric Institute, New York, NY, United States
    • ,
  • Julie Messinger

      Affiliations

    • New York University, School of Medicine, Department of Psychiatry, New York, NY, United States
    • ,
  • Jill Harkavy-Friedman

      Affiliations

    • Columbia University, College of Physicians and Surgeons, Department of Psychiatry, New York, NY, United States
    • New York State Psychiatric Institute, New York, NY, United States
    • ,
  • Dolores Malaspina

      Affiliations

    • New York University, School of Medicine, Department of Psychiatry, New York, NY, United States

Received 24 June 2009 ,Revised 1 October 2009 ,Accepted 22 October 2009.

References 

  1. Byrne M, Agerbo E, Ewald H, Eaton WW, Mortensen PB. Parental age and risk of schizophrenia: a case-control study. Arch. Gen. Psychiatry. 2003;60(7):673–678
  2. Brown AS, Schaefer CA, Wyatt RJ, Begg MD, Goetz R, Bresnahan MA, et al. Paternal age and risk of schizophrenia in adult offspring. Am. J. Psychiatry. 2002;159(9):1528–1533
  3. Dalman C, Allebeck P. Paternal age and schizophrenia: further support for an association. Am. J. Psychiatry. 2002;159:1591–1592
  4. El-Saadi O, Pedersen CB, McNeil TF, Saha S, Welham J, O'Callaghan E, et al. Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia. Schizophr Res. 2004;67:227–236
  5. Kay SR, Opler LA, Lindenmayer JP. The positive and negative syndrome scale (PANSS): rationale and standardisation. Br. J. Psychiatry. 1989;155:59–65
  6. Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D, et al. Advancing paternal age and the risk of schizophrenia. Arch. Gen. Psychiatry. 2001;58:361–367
  7. Malaspina D, Corcoran C, Fahim C, Berman A, Harkavy-Friedman J, Yale S, et al. Paternal age and sporadic schizophrenia: evidence for de novo mutations. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2002;114:299–303
  8. Sipos A, Rasmussen F, Harrison G, Tynelius P, Lewis G, Leon DA, et al. Paternal age and schizophrenia: a population based cohort study. BMJ. 2004;329:1070
  9. SPSS 15.0 for Windows. Release 15.0.0, Copyright © SPSS Inc. 1989–2006;
  10. Wohl M, Gorwood P. Paternal ages below or above 35years old are associated with a different risk of schizophrenia in the offspring. Eur. Psychiatry. 2006;22:22–26
  11. Zammit S, Allebeck P, Dalman C, Lundberg I, Hemmingson T, Owen MJ, et al. Paternal age and risk for schizophrenia. Br. J. Psychiatry. 2003;183:405–408

PII: S0920-9964(09)00542-8

doi: 10.1016/j.schres.2009.10.020

Schizophrenia Research
Volume 116, Issue 2 , Pages 191-195 , February 2010

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