Schizophrenia Research
Volume 116, Issue 1 , Pages 16-19 , January 2010

Prevention of antipsychotic-induced weight gain with early behavioural intervention in first-episode psychosis: 2-year results of a randomized controlled trial

  • Mario Álvarez-Jiménez

      Affiliations

    • “Marques de Valdecilla” Public Foundation-Research Institute (FMV-IFIMAV), Santander, Spain
    • Corresponding Author InformationCorresponding author.
    • ,
  • Obdulia Martínez-García

      Affiliations

    • University Hospital “Marqués de Valdecilla”, CIBERSAM, Department of Psychiatry, Spain
    • University of Cantabria, Spain
    • ,
  • Rocío Pérez-Iglesias

      Affiliations

    • University Hospital “Marqués de Valdecilla”, CIBERSAM, Department of Psychiatry, Spain
    • ,
  • Mari Luz Ramírez

      Affiliations

    • University Hospital “Marqués de Valdecilla”, CIBERSAM, Department of Psychiatry, Spain
    • ,
  • Jose Luis Vázquez-Barquero

      Affiliations

    • University Hospital “Marqués de Valdecilla”, CIBERSAM, Department of Psychiatry, Spain
    • University of Cantabria, Spain
    • ,
  • Benedicto Crespo-Facorro

      Affiliations

    • University Hospital “Marqués de Valdecilla”, CIBERSAM, Department of Psychiatry, Spain
    • University of Cantabria, Spain

Received 7 May 2009 ,Revised 10 October 2009 ,Accepted 18 October 2009.

References 

  1. Allison DB, Casey DE. Antipsychotic-induced weight gain: a review of the literature. J. Clin. Psychiatry. 2001;62(Suppl 7):22–31
  2. Alvarez-Jimenez M, Gonzalez-Blanch C, Vazquez-Barquero JL, Perez-Iglesias R, Martinez-Garcia O, Perez-Pardal T, et al. Attenuation of antipsychotic-induced weight gain with early behavioral intervention in drug-naive first-episode psychosis patients: a randomized controlled trial. J. Clin. Psychiatry. 2006;67:1253–1260
  3. Alvarez-Jimenez M, Gonzalez-Blanch C, Crespo-Facorro B, Hetrick S, Rodriguez-Sanchez JM, Perez-Iglesias R, et al. Antipsychotic-induced weight gain in chronic and first-episode psychotic disorders: a systematic critical reappraisal. CNS Drugs. 2008;22:547–562
  4. Alvarez-Jimenez M, Hetrick SE, Gonzalez-Blanch C, Gleeson JF, McGorry PD. Non-pharmacological management of antipsychotic-induced weight gain: systematic review and meta-analysis of randomised controlled trials. Br. J. Psychiatry. 2008;193:101–107
  5. Andreasen NC. Scale for the Assessment of Positive Symptoms (SAPS). Iowa City: University of Iowa; 1983;
  6. APA. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association; 1994;
  7. Aronne LJ, Wadden T, Isoldi KK, Woodworth KA. When prevention fails: obesity treatment strategies. Am. J. Med. 2009;122:S24–S32
  8. Lingjaerde O, Ahlfors UG, Bech P, Dencker SJ, Elgen K. The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr. Scand., Suppl. 1987;334:1–100
  9. McCreadie R, Macdonald E, Blacklock C, Tilak-Singh D, Wiles D, Halliday J, et al. Dietary intake of schizophrenic patients in Nithsdale, Scotland: case-control study. BMJ. 1998;317:784–785
  10. Perez-Iglesias R, Crespo-Facorro B, Martinez-Garcia O, Ramirez-Bonilla ML, Alvarez-Jimenez M, Pelayo-Teran JM, et al. Weight gain induced by haloperidol, risperidone and olanzapine after 1year: findings of a randomized clinical trial in a drug-naive population. Schizophr. Res. 2008;99:13–22
  11. Rossner S, Hammarstrand M, Hemmingsson E, Neovius M, Johansson K. Long-term weight loss and weight-loss maintenance strategies. Obes. Rev. 2008;9:624–630
  12. Wing RR, Hill JO. Successful weight loss maintenance. Annu. Rev. Nutr. 2001;21:323–341
  13. Wirshing DA. Schizophrenia and obesity: impact of antipsychotic medications. J. Clin. Psychiatry. 2004;65(Suppl. 18):13–26

PII: S0920-9964(09)00499-X

doi: 10.1016/j.schres.2009.10.012

Schizophrenia Research
Volume 116, Issue 1 , Pages 16-19 , January 2010

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