Schizophrenia Research
Volume 115, Issue 2 , Pages 173-181 , December 2009

Meta-analysis of magnetic resonance imaging studies in chromosome 22q11.2 deletion syndrome (velocardiofacial syndrome)

  • Giles M. Tan

      Affiliations

    • Section of Brain Maturation, PO Box 50, Division of Psychological Medicine & Psychiatry, Institute of Psychiatry at the Maudsley, King's College London, De Crespigny Park, London, SE5 8AF, United Kingdom
    • Authors contributed equally to the work.
    • ,
  • Danilo Arnone

      Affiliations

    • Neuroscience and Psychiatry Unit, Stopford Building, Manchester, United Kingdom
    • University Department of Psychiatry, Oxford, United Kingdom
    • Corresponding Author InformationCorresponding author. Neuroscience and Psychiatry Unit, University of Manchester, G810 Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom.
    • Authors contributed equally to the work.
    • ,
  • Andrew M. McIntosh

      Affiliations

    • University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    • ,
  • Klaus P. Ebmeier

      Affiliations

    • University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    • University Department of Psychiatry, Oxford, United Kingdom

Received 24 May 2009 ,Revised 12 August 2009 ,Accepted 7 September 2009.

References 

  1. Antshel KM, AbdulSabur N, Roizen N, Fremont W, Kates WR. Sex differences in cognitive functioning in velocardiofacial syndrome (VCFS). Dev. Neuropsychol. 2005;28(3):849–869
  2. Antshel KM, Conchelos J, Lanzetta G, Fremont W, Kates WR. Behavior and corpus callosum morphology relationships in velocardiofacial syndrome (22q11.2 deletion syndrome). Psychiatry Res. 2005;138(3):235–245
  3. Arinami T. Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia. J. Hum. Genet. 2006;51(12):1037–1045
  4. Arnone D, McIntosh AM, Chandra P, Ebmeier KP. Meta-analysis of magnetic resonance imaging studies of the corpus callosum in bipolar disorder. Acta Psychiatr. Scand. 2008;118(5):357–362
  5. Arnone D, McIntosh AM, Tan GM, Ebmeier KP. Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia. Schizophr. Res. 2008;101(1–3):124–132
  6. Baker KD, Skuse DH. Adolescents and young adults with 22q11 deletion syndrome: psychopathology in an at-risk group. Br. J. Psychiatry. 2005;186:115–120
  7. Bassett AS, Chow WC. Schizophrenia and 22q11.2 deletion syndrome. Curr. Psychiatry Rep. 2008;10(2):148–157
  8. Bearden CE, van Erp TG, Monterosso JR, Simon TJ, Glahn DC, Saleh PA, et al. Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptoms. Neurocase. 2004;10(3):198–206
  9. Bearden CE, van Erp TG, Dutton RA, Tran H, Zimmermann L, Sun D, et al. Mapping cortical thickness in children with 22q11.2 deletions. Cereb. Cortex. 2007;17(8):1889–1898
  10. Boot E, Booij J, Zinkstok J, Abeling N, de Haan L, Baas F, et al. Disrupted dopaminergic neurotransmission in 22q11 deletion syndrome. Neuropsychopharmacology. 2008;33(6):1252–1258
  11. Borgwardt SJ, Riecher-Rossler A, Dazzan P, Chitnis X, Aston J, Drewe M, et al. Regional gray matter volume abnormalities in the at risk mental state. Biol. Psychiatry. 2007;61:1148–1156
  12. Campbell LE, Daly E, Toal F, Stevens A, Azuma R, Catani M, et al. Brain and behaviour in children with 22q11.2 deletion syndrome: a volumetric and voxel-based morphometry MRI study. Brain. 2006;129(Pt 5):1218–1228
  13. Chow EW, Zipursky RB, Mikulis DJ, Bassett AS. Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome. Biol. Psychiatry. 2002;51(3):208–215
  14. Debbane M, Schaer M, Farhoumand R, Glaser B, Eliez S. Hippocampal volume reduction in 22q11.2 deletion syndrome. Neuropsychologia. 2006;44(12):2360–2365
  15. Deboer T, Wu Z, Lee A, Simon TJ. Hippocampal volume reduction in children with chromosome 22q11.2 deletion syndrome is associated with cognitive impairment. Behav. Brain Funct. 2007;3:54
  16. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control. Clin. Trials. 1986;7(3):177–188
  17. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–634
  18. Eliez S, Schmitt JE, White CD, Reiss AL. Children and adolescents with velocardiofacial syndrome: a volumetric MRI study. Am. J. Psychiatry. 2000;157(3):409–415
  19. Eliez S, Antonarakis SE, Morris MA, Dahoun SP, Reiss AL. Parental origin of the deletion 22q11.2 and brain development in velocardiofacial syndrome: a preliminary study. Arch. Gen. Psychiatry. 2001;58(1):64–68
  20. Eliez S, Blasey CM, Schmitt EJ, White CD, Hu D, Reiss AL. Velocardiofacial syndrome: are structural changes in the temporal and mesial temporal regions related to schizophrenia?. Am. J. Psychiatry. 2001;158(3):447–453
  21. Eliez S, Schmitt JE, White CD, Wellis VG, Reiss AL. A quantitative MRI study of posterior fossa development in velocardiofacial syndrome. Biol. Psychiatry. 2001;49(6):540–546
  22. Eliez S, Barnea-Goraly N, Schmitt JE, Liu Y, Reiss AL. Increased basal ganglia volumes in velo-cardio-facial syndrome (deletion 22q11.2). Biol. Psychiatry. 2002;52(1):68–70
  23. Ellison-Wright I, Bullmore E. Meta-analysis of diffusion tensor imaging studies in schizophrenia. Schizophr. Res. 2009;108(1–3):3–10
  24. Ellison-Wright I, Glahn DC, Laird AR, Thelen SM, Bullmore E. The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis. Am. J. Psychiatry. 2008;165(8):1015–1023
  25. Glaser B, Schaer M, Berney S, Debbane M, Vuilleumier P, Eliez S. Structural changes to the fusiform gyrus: a cerebral marker for social impairments in 22q11.2 deletion syndrome?. Schizophr. Res. 2007;96(1–3):82–86
  26. Gothelf D, Presburger G, Levy D, Nahmani A, Burg M, Berant M, et al. Genetic, developmental, and physical factors associated with attention deficit hyperactivity disorder in patients with velocardiofacial syndrome. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004;126B(1):116–121
  27. Gothelf D, Presburger G, Zohar AH, Burg M, Nahmani A, Frydman M, et al. Obsessive–compulsive disorder in patients with velocardiofacial (22q11 deletion) syndrome. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004;126B(1):99–105
  28. Gothelf D, Eliez S, Thompson T, Hinard C, Penniman L, Feinstein C, et al. COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome. Nat. Neurosci. 2005;8(11):1500–1502
  29. Gothelf D, Penniman L, Gu E, Eliez S, Reiss AL. Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome: a longitudinal study. Schizophr. Res. 2007;96(1–3):72–81
  30. Gothelf D, Schaer M, Eliez S. Genes, brain development and psychiatric phenotypes in velo-cardio-facial syndrome. Dev. Disabil. Res. Rev. 2008;14(1):59–68
  31. Henry JC, van Amelsvoort T, Morris RG, Owen MJ, Murphy DG, Murphy KC. An investigation of the neuropsychological profile in adults with velo-cardio-facial syndrome (VCFS). Neuropsychologia. 2002;40(5):471–478
  32. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560
  33. Kates WR, Burnette CP, Jabs EW, Rutberg J, Murphy AM, Grados M, et al. Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis. Biol. Psychiatry. 2001;49(8):677–684
  34. Kates WR, Burnette CP, Bessette BA, Folley BS, Strunge L, Jabs EW, et al. Frontal and caudate alterations in velocardiofacial syndrome (deletion at chromosome 22q11.2). J. Child Neurol. 2004;19(5):337–342
  35. Kates WR, Antshel K, Willhite R, Bessette BA, AbdulSabur N, Higgins AM. Gender-moderated dorsolateral prefrontal reductions in 22q11.2 Deletion Syndrome: implications for risk for schizophrenia. Child Neuropsychol. 2005;11(1):73–85
  36. Kates WR, Miller AM, Abdulsabur N, Antshel KM, Conchelos J, Fremont W, et al. Temporal lobe anatomy and psychiatric symptoms in velocardiofacial syndrome. J. Am. Acad. Child Adolesc. Psych. 2006;45(5):587–595
  37. Machado AM, Simon TJ, Nguyen V, McDonald-McGinn DM, Zackai EH, Gee JC. Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome. Brain Res. 2007;1131(1):197–210
  38. McDonald-McGinn DM, Kirschner R, Goldmuntz E, Sullivan K, Eicher P, Gerdes M, et al. The Philadelphia story: the 22q11.2 deletion: report on 250 patients. Genet. Couns. 1999;10(1):11–24
  39. Murphy KC, Owen MJ. Velo-cardio-facial syndrome: a model for understanding the genetics and pathogenesis of schizophrenia. Br. J. Psychiatry. 2001;179:397–402
  40. Murphy KC, Jones RG, Griffiths E, Thompson PW, Owen MJ. Chromosome 22q11 deletions: an under recognized cause of idiopathic learning disability. Br. J. Psychiatry. 1998;172:180–183
  41. Murphy KC, Jones LA, Owen MJ. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch. Gen. Psychiatry. 1999;56:940–945
  42. Nelson, M.D., Saykin, A.J., Riordan, H.J., 1998. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch. Gen. Psychiatry 55 (5), 433–440.
  43. Niklasson L, Rasmussen P, Oskarsdóttir S, Gillberg C. Chromosome 22q11 deletion syndrome (CATCH 22): neuropsychiatric and neuropsychological aspects. Dev. Med. Child Neurol. 2002;44(1):44–50
  44. Pantelis C, Velakoulis D, McGorry PD, Wood SJ, Suckling J, Phillips LJ, et al. Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet. 2003;361(9354):281–288
  45. Papolos DF, Faedda GL, Veit S, Goldberg R, Morrow B, Kucherlapati R, et al. Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder?. Am. J. Psychiatry. 1996;153(12):1541–1547
  46. Scambler PJ, Kelly D, Lindsay E, Williamson R, Goldberg R, Shprintzen R, et al. Velo-cardio-facial syndrome associated with chromosome 22 deletions encompassing the DiGeorge locus. Lancet. 1992;339(8802):1138–1139
  47. Shashi V, Muddasani S, Santos CC, Berry MN, Kwapil TR, Lewandowski E, et al. Abnormalities of the corpus callosum in nonpsychotic children with chromosome 22q11 deletion syndrome. NeuroImage. 2004;21(4):1399–1406
  48. Simon TJ, Ding L, Bish JP, McDonald-McGinn DM, Zackai EH, Gee J. Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study. NeuroImage. 2005;25(1):169–180
  49. Swillen A, Devriendt K, Legius E, Eyskens B, Dumoulin M, Gewillig M, et al. J. Med. Genet. 1997;34(6):453–458
  50. Takahashi T, Wood SJ, Yung AR, Soulsby B, McGorry PD, Suzuki M, et al. Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis. Arch. Gen. Psychiatry. 2009;66(4):366
  51. Tang CY, Friedman J, Shungu D, Chang L, Ernst T, Stewart D, et al. Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patientsmand normal controls. BMC Psychiatry. 2007;7:25
  52. Tézenas Du Montcel S, Mendizabai H, Aymé S, Lévy A, Philip N. Prevalence of 22q11 microdeletion. J. Med. Genet. 1996;33(8):719
  53. van Amelsvoort T, Daly E, Henry J, Robertson D, Ng V, Owen M, et al. Brain anatomy in adults with velocardiofacial syndrome with and without schizophrenia: preliminary results of a structural magnetic resonance imaging study. Arch. Gen. Psychiatry. 2004;61(11):1085–1096
  54. van Amelsvoort T, Zinkstok J, Figee M, Daly E, Morris R, Owen MJ, et al. Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndrome. Psychol. Med. 2008;38(1):89–100
  55. Williams NM, Norton N, Williams H, Ekholm B, Hamshere ML, Lindblom Y, et al. A systematic genomewide linkage study in 353 sib pairs with schizophrenia. Am. J. Hum. Genet. 2003;73(6):1355–1367
  56. Witthaus H., Kaufmann C., Bohner G., Ozgürdal S., Gudlowski Y., Gallinat J., Ruhrmann S., Brüne M., Heinz A., Klingebiel R., Juckel G., 2009. Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls. Psychiatry Res. 173, 163–169.
  57. Yan W, Jacobsen LK, Krasnewich DM, Guan XY, Lenane MC, Paul SP, et al. Chromosome 22q11.2 interstizial deletions among childhood onset schizophrenics and ‘multidimensionally impaired’. Am. J. Med. Genet. 1998;81:41–43

PII: S0920-9964(09)00429-0

doi: 10.1016/j.schres.2009.09.010

Schizophrenia Research
Volume 115, Issue 2 , Pages 173-181 , December 2009

Article Tools

* Image Usage & Resolution