Schizophrenia Research
Volume 117, Issue 1 , Pages 61-67 , March 2010

Auditory gating deficit to human voices in schizophrenia: A MEG study

  • Yoji Hirano

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Shogo Hirano

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Toshihiko Maekawa

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Choji Obayashi

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Naoya Oribe

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Akira Monji

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Kiyoto Kasai

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    • ,
  • Shigenobu Kanba

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Toshiaki Onitsuka

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • Corresponding Author InformationCorresponding author. Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashiku, Fukuoka, 812-8582, Japan. Tel.: +81 92 642 5627; fax: +81 92 642 5644.

Received 26 January 2009 ,Revised 21 July 2009 ,Accepted 1 September 2009.

References 

  1. Adler LE, Freedman R, Ross RG, Olincy A, Waldo MC. Elementary phenotypes in the neurobiological and genetic study of schizophrenia. Biol. Psychiatry. 1999;46(1):8–18
  2. Adler LE, Olincy A, Cawthra AM, McRae KA, Harris JG, Nagamoto HT, et al. Varied effects of atypical neuroleptics on P50 auditory gating in schizophrenia patients. Am. J. Psychiatry. 2004;161(10):1822–1828
  3. Adler LE, Pachtman E, Franks RD, Pecevich M, Waldo MC, Freedman R. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol. Psychiatry. 1982;17(6):639–654
  4. Adler LE, Waldo MC, Tatcher A, Cawthra E, Baker N, Freedman R. Lack of relationship of auditory gating defects to negative symptoms in schizophrenia. Schizophr. Res. 1990;3(2):131–138
  5. Andreasen NC. Methods for assessing positive and negative symptoms. Mod. Probl. Pharmacopsychiatry. 1990;24:73–88
  6. Andreasen NC, Flaum M. Schizophrenia: the characteristic symptoms. Schizophr. Bull. 1991;17(1):27–50
  7. Blanchard JJ, Kring AM, Neale JM. Flat affect in schizophrenia: a test of neuropsychological models. Schizophr. Bull. 1994;20(2):311–325
  8. Blonder LX, Bowers D, Heilman KM. The role of the right hemisphere in emotional communications. Brain. 1991;114(3):1115–1127
  9. Boatman D. Cortical bases of speech perception: evidence from functional lesion studies. Cognition. 2004;92(1–2):47–65
  10. Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophr. Bull. 1993;19(2):233–259
  11. Bramon E, Rabe-Hesketh S, Sham P, Murray RM, Frangou S. Meta-analysis of the P300 and P50 waveforms in schizophrenia. Schizophr. Res. 2004;70(2-3):315–329
  12. Clementz BA, Geyer MA, Braff DL. P50 suppression among schizophrenia and normal comparison subjects: a methodological analysis. Biol. Psychiatry. 1997;41(10):1035–1044
  13. Clementz BA, Geyer MA, Braff DL. Poor P50 suppression among schizophrenia patients and their first-degree biological relatives. Am. J. Psychiatry. 1998;155(12):1691–1694
  14. Cullum CM, Harris JG, Waldo MC, Smernoff E, Madison A, Nagamoto HT, et al. Neurophysiological and neuropsychological evidence for attention dysfunction in schizophrenia. Schizophr. Res. 1993;10(2):131–141
  15. Daskalakis ZJ, Fitzgerald PB, Christensen BK. The role of cortical inhibition in the pathophysiology and treatment of schizophrenia. Brain. Res. Rev. 2007;56(2):427–442
  16. Deng C, Huang XF. Increased density of GABAA receptors in the superior temporal gyrus in schizophrenia. Exp. Brain Res. 2006;168(4):587–590
  17. Dierks T, Linden DE, Jandl M, Formisano E, Goebel R, Lanfermann H, et al. Activation of Heschl's gyrus during auditory hallucinations. Neuron. 1999;22(3):615–621
  18. Edgar JC, Weisend MP, Sherwood A, Miller GA, Adler LE, Canive JM. Interpreting abnormality: An EEG and MEG study of P50 and the auditory paired-stimulus paradigm. Biol. Psychol. 2003;65(1):1–20
  19. Eichhammer P, Wiegand R, Kharraz A, Langguth B, Binder H, Hajak G. Cortical excitability in neuroleptic-naive first-episode schizophrenic patients. Schizophr. Res. 2004;67(2–3):253–259
  20. Freedman R, Adams CE, Adler LE, Bickford PC, Gault J, Harris JG, et al. Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia. Am. J. Med. Genet. 2000;97(1):58–64
  21. Freedman R, Adler LE, Myles-Worsley M, Nagamoto HT, Miller C, Kisley M, et al. Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Human recordings, computer simulation, and an animal model. Arch. Gen. Psychiatry. 1996;53(12):1114–1121
  22. Freedman R, Adler LE, Olincy A, Waldo MC, Ross RG, Stevens KE, et al. Input dysfunction, schizotypy, and genetic models of schizophrenia. Schizophr. Res. 2002;54(1–2):25–32
  23. Freedman R, Waldo M, Bickford-Wimer P, Nagamoto H. Elementary neuronal dysfunctions in schizophrenia. Schizophr. Res. 1991;4(2):233–243
  24. Fuerst DR, Gallinat J, Boutros NN. Range of sensory gating values and test–retest reliability in normal subjects. Psychophysiology. 2007;44(4):620–626
  25. Hämäläinen M, Hari R, Ilmoniemi RJ, Knuutila J, Lounasmaa OV. Magnetoencephalography — theory, instrumentation, and applications to noninvasive studies of the working human brain. Rev. Mod. Phys. 1993;65(2):413–497
  26. Heilman KM, Bowers D, Speedie L, Coslett HB. Comprehension of affective and nonaffective prosody. Neurology. 1984;34(7):917–921
  27. Heinrichs RW. Meta-analysis and the science of schizophrenia: variant evidence or evidence of variants?. Neurosci. Biobehav. Rev. 2004;28(4):379–394
  28. Hirano S, Hirano Y, Maekawa T, Obayashi C, Oribe N, Kuroki T, et al. Abnormal neural oscillatory activity to speech sounds in schizophrenia: a magnetoencephalography study. J. Neurosci. 2008;28(19):4897–4903
  29. Hoddes E, Zarcone V, Smythe H, Phillips R, Dement WC. Quantification of sleepiness: a new approach. Psychophysiology. 1973;10(4):431–436
  30. Hoffman RE, Cavus I. Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. Am. J. Psychiatry. 2002;159(7):1093–1102
  31. Hoffman RE, Hawkins KA, Gueorguieva R, Boutros NN, Rachid F, Carroll K, et al. Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Arch. Gen. Psychiatry. 2003;60(1):49–56
  32. Hollingshead AB. Two Factor Index of Social Position. New Haven, Conn: Yale University Press; 1965;
  33. Huang MX, Edgar JC, Thoma RJ, Hanlon FM, Moses SN, Lee RR, et al. Predicting EEG responses using MEG sources in superior temporal gyrus reveals source asynchrony in patients with schizophrenia. Clin. Neurophysiol. 2003;114(5):835–850
  34. Hubl D, Koenig T, Strik WK, Garcia LM, Dierks T. Competition for neuronal resources: how hallucinations make themselves heard. Br. J. Psychiatry. 2007;190:57–62
  35. Judd LL, McAdams L, Budnick B, Braff DL. Sensory gating deficits in schizophrenia: new results. Am. J. Psychiatry. 1992;149(4):488–493
  36. Leahy RM, Mosher JC, Spencer ME, Huang MX, Lewine JD. A study of dipole localization accuracy for MEG and EEG using a human skull phantom. Electroencephalogr. Clin. Neurophysiol. 1998;107(2):159–173
  37. Levitan C, Ward PB, Catts SV. Superior temporal gyral volumes and laterality correlates of auditory hallucinations in schizophrenia. Biol. Psychiatry. 1999;46(7):955–962
  38. Louchart-de la Chapelle S, Levillain D, Ménard JF, Van der Elst A, Allio G, Haouzir S, et al. P50 inhibitory gating deficit is correlated with the negative symptomatology of schizophrenia. Psychiatry Res. 2005;36(1):27–34
  39. Lu BY, Edgar JC, Jones AP, Smith AK, Huang MX, Miller GA, et al. Improved test–retest reliability of 50-ms paired-click auditory gating using magnetoencephalography source modeling. Psychophysiology. 2007;44(1):86–90
  40. Myles-Worsley M. P50 sensory gating in multiplex schizophrenia families from a Pacific island isolate. Am. J. Psychiatry. 2002;159(12):2007–2012
  41. Oldfield RC. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia. 1971;9(1):97–113
  42. Onitsuka T, Ninomiya H, Sato E, Yamamoto T, Tashiro N. The effect of interstimulus intervals and between-block rests on the auditory evoked potential and magnetic field: is the auditory P50 in humans an overlapping potential?. Clin. Neurophysiol. 2000;111(2):237–245
  43. Onitsuka T, Shenton ME, Salisbury DF, Dickey CC, Kasai K, Toner SK, et al. Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study. Am. J. Psychiatry. 2004;161(9):1603–1611
  44. Pell MD. Recognition of prosody following unilateral brain lesion: influence of functional and structural attributes of prosodic contours. Neuropsychologia. 1998;36(8):701–715
  45. Potkin SG, Alva G, Fleming K, Anand R, Keator D, Carreon D, et al. A PET study of the pathophysiology of negative symptoms in schizophrenia. Positron emission tomography.. Am. J. Psychiatry. 2002;159(2):227–237
  46. Potter D, Summerfelt A, Gold J, Buchanan RW. Review of clinical correlates of P50 sensory gating abnormalities in patients with schizophrenia. Schizophr. Bull. 2005;32(4):692–700
  47. Ringel TM, Heidrich A, Jacob CP, Fallgatter AJ. Sensory gating deficit in a subtype of chronic schizophrenic patients. Psychiatry Res. 2004;125(3):237–245
  48. Sartorius N, Jablensky A, Korten A, Ernberg G, Anker M, Cooper JE, et al. Early manifestations and first-contact incidence of schizophrenia in different cultures. A preliminary report on the initial evaluation phase of the WHO Collaborative Study on determinants of outcome of severe mental disorders.. Psychol. Med. 1986;16(4):909–928
  49. Siegel C, Waldo M, Mizner G, Adler LE, Freedman R. Deficits in sensory gating in schizophrenic patients and their relatives. Evidence obtained with auditory evoked responses.. Arch. Gen. Psychiatry. 1984;41(6):607–612
  50. Thoma RJ, Hanlon FM, Moses SN, Edgar JC, Huang M, Weisend MP, et al. Lateralization of auditory sensory gating and neuropsychological dysfunction in schizophrenia. Am. J. Psychiatry. 2003;160(9):1595–1605
  51. Thoma RJ, Hanlon FM, Moses SN, Ricker D, Huang M, Edgar C, et al. M50 sensory gating predicts negative symptoms in schizophrenia. Schizophr. Res. 2005;73(2–3):311–318
  52. Venables PH. Input dysfunction in schizophrenia. In:  Maher B editors. Progress in Experimental Personality Research. New York: NY Academic Press; 1964;p. 1–47
  53. Waldo MC, Carey G, Myles-Worsley M, Cawthra E, Adler LE, Nagamoto HT, et al. Codistribution of a sensory gating deficit and schizophrenia in multi-affected families. Psychiatry Res. 1991;39(3):257–268
  54. Woodruff PW. Auditory hallucinations: insights and questions from neuroimaging. Cogn. Neuropsychiatry. 2004;9(1–2):73–91

PII: S0920-9964(09)00421-6

doi: 10.1016/j.schres.2009.09.003

Schizophrenia Research
Volume 117, Issue 1 , Pages 61-67 , March 2010

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