Schizophrenia Research
Volume 115, Issue 2 , Pages 146-155 , December 2009

Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis

  • Preethi Premkumar

      Affiliations

    • Department of Psychology, Institute of Psychiatry, King's College London, London, UK
    • ,
  • Dominic Fannon

      Affiliations

    • Department of Psychology, Institute of Psychiatry, King's College London, London, UK
    • ,
  • Elizabeth Kuipers

      Affiliations

    • Department of Psychology, Institute of Psychiatry, King's College London, London, UK
    • NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, London, UK
    • ,
  • Emmanuelle R. Peters

      Affiliations

    • Department of Psychology, Institute of Psychiatry, King's College London, London, UK
    • NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, London, UK
    • ,
  • Ananatha P.P. Anilkumar

      Affiliations

    • South London and Maudsley NHS Trust, London, UK
    • ,
  • Andrew Simmons

      Affiliations

    • NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, London, UK
    • Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK
    • ,
  • Veena Kumari

      Affiliations

    • Department of Psychology, Institute of Psychiatry, King's College London, London, UK
    • NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, London, UK
    • Corresponding Author InformationCorresponding author. Department of Psychology, PO78, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. Tel.: +44 207 848 0233; fax: +44 207 848 0860.

Received 17 April 2009 ,Revised 7 August 2009 ,Accepted 8 August 2009.

  • Image Result

    Grey matter areas (maps thresholded at p=0.005 uncorrected) showing a positive association with symptom improvement following CBTp in patients.

    Grey matter areas (maps thresholded at p=0.005 uncorrected) showing a positive association with symptom improvement following CBTp in patients.

  • Image Result

    Scatter plots showing the relationship between the percentage grey matter volumes (relative to group mean) at the maxima voxel of all the regions (y-axis) showing an association with symptom change (x

    Scatter plots showing the relationship between the percentage grey matter volumes (relative to group mean) at the maxima voxel of all the regions (y-axis) showing an association with symptom change (x-axis) for CBTp+SC patients receiving clozapine or other antipsychotics.

  • Image Result
    Greater posterior hippocampal volume (maps thresholded at p=0.05 uncorrected) in CBTp+SC responders relative to healthy participants and CBTp+SC non-responders.

    Greater posterior hippocampal volume (maps thresholded at p=0.05 uncorrected) in CBTp+SC responders relative to healthy participants and CBTp+SC non-responders.

PII: S0920-9964(09)00381-8

doi: 10.1016/j.schres.2009.08.007

Schizophrenia Research
Volume 115, Issue 2 , Pages 146-155 , December 2009

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