Schizophrenia Research
Volume 112, Issue 1 , Pages 91-98 , July 2009

Cognitive mechanisms underlying disorganization of thought in a genetic syndrome (47,XXY)

  • Sophie Van Rijn

      Affiliations

    • Leiden University, Clinical Child and Adolescent Studies, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands
    • University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    • Corresponding Author InformationCorresponding author. Leiden University, Faculty of Social Sciences, Department of Clinical Child and Adolescent Studies, Wassenaarseweg 52, 2333 AK, Leiden, The Netherlands.
    • ,
  • André Aleman

      Affiliations

    • University of Groningen, BCN NeuroImaging Center, A. Deusinglaan 2, 9713 AW Groningen, The Netherlands
    • ,
  • Leo De Sonneville

      Affiliations

    • Leiden University, Clinical Child and Adolescent Studies, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands
    • ,
  • Hanna Swaab

      Affiliations

    • Leiden University, Clinical Child and Adolescent Studies, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands
    • University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands

Received 1 December 2008 ,Revised 7 April 2009 ,Accepted 12 April 2009.

References 

  1. Anderson V. Assessing executive functions in children: biological, psychological, and developmental considerations. Pediatr. Rehabil. 2001;4(3):119–136
  2. Andreasen NC. Scale for the assessment of thought, language, and communication (tlc). Schizophr. Bull. 1986;12(3):473
  3. Bojesen A, Juul S, Gravholt CH. Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study. J. Clin. Endocrinol. Metab. 2003;88(2):622–626
  4. Bojesen A, Juul S, Birkebaek NH, Gravholt CH. Morbidity in Klinefelter syndrome; a Danish register study based on hospital discharge diagnoses. J. Clin. Endocrinol. Metab. 2006;91(4):1254–1260
  5. Boks MPM, de Vette MHT, Sommer IE, van Rijn S, Giltay JC, Swaab H, et al. Psychiatric morbidity and x-chromosomal origin in a Klinefelter sample. Schizophr. Res. 2007;93(1–3):399–402
  6. Boone KB, Swerdloff RS, Miller BL, Geschwind DH, Razani J, Lee A, et al. Neuropsychological profiles of adults with Klinefelter syndrome. J. Int. Neuropsychol. Soc. 2001;7(4):446–456
  7. Bouma JM. Dichotic listening and hemispheric specialization: theoretical considerations and clinical implications. In:  Licht AB,  Bouma A,  Slot W,  Koops W editor. Child neuropsychology. Reading disabilities and more…. Delft: Eburon; 1998;
  8. Bruining H, Swaab H, Kas M, Van Engeland H. Psychiatric characteristics in a self-selected sample of boys with Klinefelter Syndrome. Pediatrics. 2009;135(5):e865–e870
  9. DeLisi LE, Friedrich U, Wahlstrom J, Boccio-Smith A, Forsman A, Eklund K, et al. Schizophrenia and sex chromosome anomalies. Schizophrenia Bulletin. 1994;20(3):495–505
  10. DeLisi LE, Maurizio AM, Svetina C, Ardekani B, Szulc K, Nierenberg J, et al. Klinefelter's syndrome (XXY) as a genetic model for psychotic disorders. Am. J. Med. Genet., B Neuropsychiatr. Genet. 2005;135(1):15–23
  11. De Sonneville LMJ. Amsterdam neuropsychological tasks: a computer-aided assessment program. In:  Den Brinker BPLM,  Beek PJ,  Brand AN,  Maarse SJ,  Mulder LJM editor. Cognitive ergonomics, clinical assessment and computer-assisted learning: computers in psychology. Lisse, The Netherlands: Swets & Zeitlinger; 1999;p. 187–203
  12. De Sonneville LMJ. Amsterdam neuropsychological tasks: scientific and clinical applications. Tijdschr. Neuropsychol. 2005;0:27–41
  13. Geschwind DH, Gregg J, Boone K, Karrim J, Pawlikowska Haddal A, Rao E, et al. Klinefelter's syndrome as a model of anomalous cerebral laterality: testing gene dosage in the x chromosome pseudoautosomal region using a DNA microarray. Dev. Genet. 1998;23(3):215–229
  14. Geschwind DH, Boone KB, Miller BL, Swerdloff RS. Neurobehavioral phenotype of klinefelter syndrome. Ment. Retard. Dev. Disabil. Res. Rev. 2000;6(2):107–116
  15. Gootjes L, Bouma A, Van Strien JW, Schijndel RV, Barkhof F, Scheltens P. Corpus callosum size correlates with asymmetric performance on a dichotic listening task in healthy aging but not in Alzheimer's disease. Neuropsychologia. 2006;44(2):208–217
  16. Hellige JB. Hemispheric asymmetry: What's right and what's left. Cambridge, MA, USA: Harvard University Press; 2001;
  17. Huijbregts S, De Sonneville L, Licht R, Sergeant J, Van Spronsen F. Inhibition of prepotent responding and attentional flexibility in treated phenylketonuria. Dev. Neuropsychol. 2002;22(2):481
  18. Itti E, Gaw Gonzalo IT, Boone KB, Geschwind DH, Berman N, Pawlikowska-Haddal A, et al. Functional neuroimaging provides evidence of anomalous cerebral laterality in adults with Klinefelter's syndrome. Ann. Neurol. 2003;54(5):669–673
  19. Itti E, Gaw Gonzalo IT, Pawlikowska-Haddal A, Boone KB, Mlikotic A, Itti L, et al. The structural brain correlates of cognitive deficits in adults with klinefelter's syndrome. J. Clin. Endocrinol. Metab. 2006;91(4):1423–1427
  20. Jha P, Sheth D, Ghaziuddin M. Autism spectrum disorder and klinefelter syndrome. Eur. Child Adolesc. Psychiatry. 2007;16(5):305–308
  21. Kerns JG, Berenbaum H. Cognitive impairments associated with formal thought disorder in people with schizophrenia. J. Abnorm. Psychology. 2002;111(2):211
  22. Kircher TTJ, Liddle PF, Brammer MJ, Williams SCR, Murray RM, McGuire PK. Reversed lateralization of temporal activation during speech production in thought disordered patients with schizophrenia. Psychol. Med. 2002;32(3):439–449
  23. Lezak MD. Neuropsychological Assessment. third ed. New York: Oxford University Press; 1995;
  24. Merhar S, Manning-Courtney P. Two boys with 47, XXY and autism. J. Autism Dev. Disord. 2007;37(5):840–846
  25. Nelson HE. National Adult Reading Test (NART), Manual. Windsor, Bershire, UK: NFER-Nelson; 1982;
  26. Netley C, Rovet J. Hemispheric lateralization in 47,XXY Klinefelter's syndrome boys. Brain Cogn. 1984;3(1):10–18
  27. Oldfield RC. The assessment and analysis of handedness: the edinburgh inventory. Neuropsychologia. 1971;9(1):97–113
  28. Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr. Bull. 1991;17(4):555–564
  29. Raven JC, Raven J, Court JH. Manual for Raven's progressive matrices and vocabulary scales. Oxford: Oxford Psychologist Press; 1993;
  30. Rommelse NNJ, Altink ME, Oosterlaan J, Buschgens CJM, Buitelaar J, Sergeant JA. Support for an independent familial segregation of executive and intelligence endophenotypes in adhd families. Psychol. Med. 2008;38(11):1595
  31. Ross JL, Roeltgen D, Stefanatos GA, Feuillan P, Kushner H, Bondy C, et al. Androgen-responsive aspects of cognition in girls with turner syndrome. J. Clin. Endocrinol. Metab. 2003;88(1):292–296
  32. Ross JL, Roeltgen DP, Stefanatos G, Benecke R, Zeger MP, Kushner H, et al. Cognitive and motor development during childhood in boys with klinefelter syndrome. Am. J. Med. Genet., A. 2008;708–719
  33. Rossi A, Daneluzzo E. Schizotypal dimensions in normals and schizophrenic patients: a comparison with other clinical samples. Schizophr. Res. 2002;54(1–2):67–75
  34. Rossi A, Serio A, Stratta P, Petruzzi C, Schiazza G, Mancini F, et al. Planum temporale asymmetry and thought disorder in schizophrenia. Schizophr. Res. 1994;12(1):1–7
  35. Salbenblatt JA, Bender BG, Puck MH. Pituitary–gonadal function in klinefelter syndrome before and during puberty. Pediatr. Res. 1985;19(1):82–86
  36. Schmand B, Bakker D, Saan R, Louman J. [The Dutch Reading Test For Adults: a measure of premorbid intelligence level]. Tijdschr. Gerontol. Geriatr. 1991;22(1):15–19
  37. Serra M, Althaus M, De Sonneville LMJ, Stant AD, Jackson AE, Minderaa RB. Face recognition in children with a pervasive developmental disorder not otherwise specified. J. Autism Dev. Disord. 2003;33(3):303
  38. Sheehan DV, L. Y. , Janavs J, Knapp E, Weiler EB, Hergueta T, et al. Mini International Neuropsychiatric Interview: Mini-Plus. Tampa: University of South Florida College of Medicine; 1994;
  39. Solomon M, Ozonoff S, Carter C, Caplan R. Formal thought disorder and the autism spectrum: relationship with symptoms, executive control, and anxiety. J. Autism Dev. Disord. 2008;1474–1484
  40. Sommer IEC, Cohen-Kettenis PT, van Raalten T, vd Veer AJ, Ramsey LE, Gooren LJG, et al. Effects of cross-sex hormones on cerebral activation during language and mental rotation: an fMRI study in transsexuals. Eur. Neuropsychopharmacol. 2008;18(3):215
  41. Stirling J, Hellewell J, Blakey A, Deakin W. Thought disorder in schizophrenia is associated with both executive dysfunction and circumscribed impairments in semantic function. Psychol. Med. 2006;36(4):475–484
  42. Temple CM, Sanfilippo PM. Executive skills in Klinefelter's syndrome. Neuropsychologia. 2003;41(11):1547–1559
  43. van Rijn S, Aleman A, Swaab H, Kahn R. Klinefelter's syndrome (karyotype 47,XXY) and schizophrenia-spectrum pathology. Br. J. Psychiatry. 2006;189(5):459–461
  44. van Rijn S, Aleman A, Swaab H, Vink M, Sommer I, Kahn RS. Effects of an extra x chromosome on language lateralization: an fmri study with klinefelter men (47,XXY). Schizophr. Res. 2008;101(1–3):17–25
  45. van Rijn S, Swaab H, Aleman A, Kahn RS. Social behavior and autism traits in a sex chromosomal disorder: Klinefelter (47 XXY) syndrome. J. Autism Dev. Disord. 2008;1–8
  46. Vollema MG, Hoijtink H. The multidimensionality of self-report schizotypy in a psychiatric population: an analysis using multidimensional Rasch models. Schizophr. Bull. 2000;26(3):565–575
  47. Wechsler D. WAIS-III Dutch Translation. Lisse: Swets & Zeitlinger; 1997;
  48. Wikström AM, Dunkel L, Wickman S, Norjavaara E, Ankarberg-Lindgren C, Raivio T. Are adolescent boys with Klinefelter syndrome androgen deficient? A longitudinal study of Finnish 47,XXY boys. Pediatr. Res. 2006;59(6):854
  49. Willshire D, Kinsella G, Prior M. Estimating WAIS-R IQ from the national adult reading test — a cross-validation. J. Clin. Exp. Neuropsychol. 1991;13(2):204–216
  50. Wisniewski AB, Prendeville MT, Dobs AS. Handedness, functional cerebral hemispheric lateralization, and cognition in male-to-female transsexuals receiving cross-sex hormone treatment. Arch. Sex. Behav. 2005;34(2):167–172
  51. Zelazo PD, Muller U. Executive function in typical and atypical development. In:  Goswami U editors. Handbook of childhood cognitive development. Oxford: Blackwell; 2002;

PII: S0920-9964(09)00181-9

doi: 10.1016/j.schres.2009.04.017

Schizophrenia Research
Volume 112, Issue 1 , Pages 91-98 , July 2009

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