Schizophrenia Research
Volume 112, Issue 1 , Pages 86-90 , July 2009

Prepulse inhibition deficits in schizophrenia are modified by smoking status

  • Andrea A. Woznica

      Affiliations

    • Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada M5T 1R8
    • Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada M5T 1R8
    • ,
  • Kristi A. Sacco

      Affiliations

    • Program for Research in Smokers with Mental Illness (PRISM), Department of Psychiatry, Yale School of Medicine, Department of Psychiatry, New Haven, Connecticut 06519, USA
    • ,
  • Tony P. George

      Affiliations

    • Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada M5T 1R8
    • Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada M5T 1R8
    • Program for Research in Smokers with Mental Illness (PRISM), Department of Psychiatry, Yale School of Medicine, Department of Psychiatry, New Haven, Connecticut 06519, USA
    • Corresponding Author InformationCorresponding author. University of Toronto, Faculty of Medicine, 250 College Street, Room CS 734, Toronto, Ontario, Canada M5T 1R8. Tel.: +1 416 535 8501x4544; fax: +1 416 979 4676.

Received 13 January 2009 ,Revised 7 April 2009 ,Accepted 9 April 2009.

References 

  1. Beck AT, Steer RA, Brown GK. Manual for the Beck Depression Inventory-II. San Antonio, TX: P. Corporation; 1996;
  2. Benowitz NL, Jacob P, Ahijevich K, Jarvis MJ, Hall S, LeHouzec J, et al. Biochemical verification of tobacco use and cessation. Report from the SRNT Subcommittee on Biochemical Verification. Nicotine Tob. Res. 2002;4:149–159
  3. Braff DL, Freedman R. Endophenotypes in studies of the genetics of schizophrenia. In:  Davis KL,  Charney DS,  Coyle JT,  Nemeroff CB editor. Neuropsychopharmacology: The Fifth Generation of Progress. New York: Lippincott, Williams and Wilkins; 2002;
  4. Braff DL, Geyer MA, Swerdlow NR. Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology. 2001;156:234–258
  5. Braff DL, Grillon C, Geyer MA. Gating and habituation of the startle reflex in schizophrenic patients. Arch. Gen. Psychiatry. 1992;49:206–215
  6. First MB. Diagnostic and Statistical Manual of Mental Disorders. 4th edition. Washington, D.C: American Psychiatric Association; 1994;DSM-IV
  7. George TP. Neurobiological links between nicotine addiction and schizophrenia. J. Dual Diagn. 2007;3(3/4):27–42
  8. George TP, Termine A, Sacco KA, Seyal AA, Dudas MM, Allen TM, et al. Effects of cigarette smoking on prepulse inhibition in schizophrenia: involvement of nicotinic receptor mechanisms. Schizophr. Res. 2006;87:307–315
  9. George TP, Vessicchio JC, Termine A, Sahady DM, Head CA, Pepper WT, et al. Effects of smoking abstinence on visuospatial working memory function in schizophrenia. Neuropsychopharmacology. 2002;26:75–85
  10. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry. 2003;160:636–645
  11. Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom KO. The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br. J. Addict. 1991;86:1119–1127
  12. Kalman D, Morrisette SB, George TP. Co-morbidity of smoking with psychiatric and substance use disorders. Am. J. Addict. 2005;14:106–123
  13. Kay SR, Fiszbein A, Opler L. The positive and negative syndrome scale for schizophrenia. Schizophr. Bull. 1987;13:261–276
  14. Kumari V, Gray JA. Smoking withdrawal, nicotine dependence and prepulse inhibition of the acoustic startle reflex. Psychopharmacology (Berl.). 1999;141:11–15
  15. Kumari V, Soni W, Sharma T. Influence of cigarette smoking on prepulse inhibition of the acoustic startle response in schizophrenia. Hum. Psychopharmacol. 2001;16:321–326
  16. Morisano D, Bacher I, Audrain-McGovern J, George TP. Mechanisms underlying the co-morbidity of tobacco use in mental health and addictive disorders. Can J. Psychiatry. 2009;54(6):141–152
  17. Postma P, Gray JA, Sharma T, Geyer M, Mehrotra R, Das M, et al. A behavioral and functional neuroimaging investigation into the effects of nicotine on sensorimotor gating in healthy subjects and persons with schizophrenia. Psychopharmacology. 2006;184:589–599
  18. Sacco KA, Bannon KL, George TP. Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders. J. Psychopharmacol. 2004;18(4):457–474
  19. Sacco KA, Termine A, Seyal AA, Dudas MM, Vessicchio JC, Krishnan-Sarin S, et al. Effects of cigarette smoking function on spatial working memory and attentional function in schizophrenia: involvement of nicotinic receptor mechanisms. Arch. Gen. Psychiatry. 2005;62:649–659
  20. Shipley WC, Burlington CC. A convenient self-administered scale for measuring intellectual impairment in psychotics. Am. J. Psychiatry. 1941;97:1313–1325
  21. Smith RC, Singh A, Infante M, Khandat A, Kloos A. Effects of cigarette smoking and nicotine nasal spray on psychiatric symptoms and cognition in schizophrenia. Neuropsychopharmacology. 2002;27:479–497
  22. Swerdlow NR, Light GA, Cadenhead KS, Sprock J, Hsieh MH, Braff DL. Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function. Arch. Gen. Psychiatry. 2006;63:1325–1335

PII: S0920-9964(09)00180-7

doi: 10.1016/j.schres.2009.04.016

Schizophrenia Research
Volume 112, Issue 1 , Pages 86-90 , July 2009

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