Schizophrenia Research
Volume 100, Issue 1 , Pages 153-160 , March 2008

Assessment of single and bound features in a working memory task in schizophrenia

  • David Luck

      Affiliations

    • INSERM U. 666, Physiopathologie clinique et expérimentale de la schizophrénie, Département de Psychiatrie, Hôpital Civil, 67091 Strasbourg Cedex, France
    • Corresponding Author InformationCorresponding author. Present address: Brain Imaging Group, Douglas Hospital Research Centre, McGill University, 6875 Boul. LaSalle, Verdun, Canada, H4H 1R3. Tel.: +1 514 761 6131x3389 (office); fax: +1 514 888 4064.
  • ,
  • Jack R. Foucher

      Affiliations

    • INSERM U. 666, Physiopathologie clinique et expérimentale de la schizophrénie, Département de Psychiatrie, Hôpital Civil, 67091 Strasbourg Cedex, France
  • ,
  • Isabelle Offerlin-Meyer

      Affiliations

    • INSERM U. 666, Physiopathologie clinique et expérimentale de la schizophrénie, Département de Psychiatrie, Hôpital Civil, 67091 Strasbourg Cedex, France
  • ,
  • Martin Lepage

      Affiliations

    • Brain Imaging Group, Douglas Hospital Research Centre, Verdun, Quebec, Canada
  • ,
  • Jean-Marie Danion

      Affiliations

    • INSERM U. 666, Physiopathologie clinique et expérimentale de la schizophrénie, Département de Psychiatrie, Hôpital Civil, 67091 Strasbourg Cedex, France

Received 27 August 2007 ,Revised 30 October 2007 ,Accepted 5 November 2007.

References 

  1. Aleman A, Hijman R, de Haan EH, Kahn RS. Memory impairment in schizophrenia: a meta-analysis. Am. J. Psychiatry. 1999;156:1358–1366
  2. American Psychiatric Association . In: Diagnostic and Statistical Manual of Mental Disorders, DSM-IV 4. 1994;p. 273–290
  3. Baddeley AD. Working Memory. Oxford: Oxford University Press; 1986;
  4. Baddeley AD. The episodic buffer: a new component of working memory?. Trends Cogn. Sci. 2000;4:417–423
  5. Baddeley AD. Working memory: looking back and looking forward.. Nat. Rev. Neurosci. 2003;4:829–839
  6. Burglen F, Marczewski P, Mitchell KJ, Van Der Linden M, Johnson MK, Danion J-M, et al. Impaired performance in a working memory binding task in patients with schizophrenia. Psychiatry Res. 2004;125:247–255
  7. Campo P, Maestu F, Ortiz T, Capilla A, Santiuste M, Fernandez A, et al. Time modulated prefrontal and parietal activity during the maintenance of integrated information as revealed by magnetoencephalography. Cereb. Cortex. 2005;15(2):123–130
  8. Carr VJ, Dewis SA, Lewin TJ. Illusory conjunctions and perceptual grouping in a visual search task in schizophrenia. Psychiatry Res. 1998;80:69–81
  9. Crawford JR, Allan KM, Jack AM. Short form of the UK WAIS-R: regression equation and their predictive validity in a general population sample. Br. J. Clin. Psychol. 1992;31:191–202
  10. Danion J-M, Rizzo L, Bruant A. Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia. Arch. Gen. Psychiatry. 1999;56:639–644
  11. Gold JM, Wilk CM, McMahon RP, Buchanan RW, Luck SJ. Working Memory for Visual Features and Conjunctions in Schizophrenia. J. Abnorm. Psychology. 2003;112:61–71
  12. Goldman-Rakic PS. Regional and cellular fractionation of working memory. Proc. Natl. Acad. Sci. U. S. A. 1996;93:13473–13480
  13. Hartman M, Steketee MC, Silva S, Lanning K, McCann H. Working memory and schizophrenia: evidence for slowed encoding. Schizophr. Res. 2002;59:99–113
  14. Fleming K, Goldberg TE, Binks S, Randolph C, Gold JM, Weinberger DR. Visuospatial working memory in patients with schizophrenia. Biol. Psychiatry. 1997;41:43–49
  15. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12:426–445
  16. Javitt DC, Rabinowicz E, Silipo G, Dias EC. Encoding vs. retention: differential effects of cue manipulation on working memory performance in schizophrenia. Schizophr. Res. 2007;91(1-3):159–168
  17. Keefe RS. Working memory dysfunction and its relevance to schizophrenia. In:  Sharma T,  Harvey PD editor. Cognition in schizophrenia: Impairments, importance, and treatment strategies. Oxford, England: Oxford University Press; 2000;p. 16–50
  18. Lee J, Park S. Working Memory Impairments in Schizophrenia: a meta-analysis. J. Abnorm. Psychology. 2005;114(4):599–611
  19. Lepage M, Montoya A, Pelletier M, Achim AM, Menear M, Lal S. Associative memory encoding and recognition in schizophrenia: an event-related fMRI study. Biol. Psychiatry. 2006;1215–1223
  20. Mitchell KJ, Johnson MK, Raye CL, Mather M, D’Esposito M. Aging and reflective processes of working memory: binding and test load deficits. Psychol. Aging. 2000;15:527–541
  21. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Arch. Gen. Psychiatry. 1992;49:975–982
  22. Park S, Holzman PS. Association of working memory deficit and eye tracking dysfunction in schizophrenia. Schizophr. Res. 1993;11:55–61
  23. Park S, Puschel J, Sauter BH, Rentsch M, Hell D. Spatial working memory deficits and clinical symptoms in schizophrenia: a 4-month follow-up study. Biol. Psychiatry. 1999;46:392–400
  24. Pelletier M, Achim AM, Montoya A, Lal S, Lepage M. Cognitive and clinical moderators of recognition memory in schizophrenia: a meta-analysis. Schizophr. Res. 2005;74:233–252
  25. Prabhakaran V, Narayanan K, Zhao Z, Gabrieli JDE. Integration of diverse information in working memory within the frontal lobe. Nat. Neurosci. 2000;3:85–90
  26. Rizzo L, Danion J-M, Van der Linden M, Grange D. Patients with schizophrenia remember that an event has occurred, but not when. Br. J. Psychiatry. 1996;168:427–431
  27. Rossi-Arnaud C, Pieroni L, Baddeley A. Symmetry and binding in visuo-spatial working memory. Neuroscience. 2005;139:393–400
  28. Saykin AJ, Gur RC, Gur RE, Mozley PD, Mozley LH, Resnik SM, et al. Neuropsychological function in schizophrenia: selective impairment in memory and learning. Arch. Gen. Psychiatry. 1991;48:618–624
  29. Spindler KA, Sullivan EV, Menon V, Lim KO, Pfefferbaum A. Deficits in multiple systems of working memory in schizophrenia. Schizophr. Res. 1997;27:1–10
  30. Stone M, Gabrieli JDE, Stebbins GT, Sullivan EV. Working and strategic memory deficits in schizophrenia.. Neuropsychology. 1998;12:278–288
  31. Tek C, Gold J, Blaxton T, Wilk C, McMahon RP, Buchanan RW. Visual perceptual and working memory impairments in schizophrenia. Arch. Gen. Psychiatry. 2002;59:146–153
  32. Waters FA, Maybery MT, Badcock JC, Michie PT. Context memory and binding in schizophrenia. Schizophr. Res. 2004;68:119–125
  33. Wu X, Chen X, Li Z, Han S, Zhang D. Binding of verbal and spatial information in human working memory involves large-scale neural synchronization at theta frequency. Neuroimage. 2007;35(4):1654–1662

PII: S0920-9964(07)00517-8

doi: 10.1016/j.schres.2007.11.004

Schizophrenia Research
Volume 100, Issue 1 , Pages 153-160 , March 2008