Schizophrenia Research
Volume 98, Issue 1 , Pages 89-97 , January 2008

Allelic association of G72/G30 with schizophrenia and bipolar disorder: A comprehensive meta-analysis

Received 21 July 2007 ,Revised 2 October 2007 ,Accepted 8 October 2007.

References 

  1. Addington AM, Gornick M, Sporn AL, Gogtay N, Greenstein D, Lenane M, et al. Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified. Biol. Psychiatry. 2004;55:976–980
  2. Badner JA, Gershon ES. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol. Psychiatry. 2002;7:405–411
  3. Bakker SC, Hoogendoorn ML, Hendriks J, Verzijlbergen K, Caron S, Verduijn W, et al. The PIP5K2A and RGS4 genes are differentially associated with deficit and non-deficit schizophrenia. Genes Brain Behav. 2007;6:113–119
  4. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263–265
  5. Bax L, Yu LM, Ikeda N, Tsuruta H, Moons KG. Development and validation of MIX: comprehensive free software for meta-analysis of causal research data. BMC Med. Res. Methodol. 2006;6:50
  6. Cardno AG, Thomas K, McGuffin P. Clinical variables and genetic loading for schizophrenia: analysis of published Danish adoption study data. Schizophr. Bull. 2002;28:393–399
  7. Chen YS, Akula N, tera-Wadleigh SD, Schulze TG, Thomas J, Potash JB, et al. Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33. Mol. Psychiatry. 2004;9:87–92
  8. Cho HJ, Meira-Lima I, Cordeiro Q, Michelon L, Sham P, Vallada H, et al. Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis. Mol. Psychiatry. 2005;10:771–781
  9. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2002;99:13675–13680
  10. Craddock N, O'Donovan MC, Owen MJ. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J. Med. Genet. 2005;42:193–204
  11. Craddock N, O'Donovan MC, Owen MJ. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr. Bull. 2006;32:9–16
  12. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control. Clin. Trials. 1986;7:177–188
  13. Detera-Wadleigh SD, McMahon FJ. G72/G30 in Schizophrenia and Bipolar Disorder: review and meta-analysis. Biol. Psychiatry. 2007;60:106–114
  14. Egger M, Davey SG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–634
  15. Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA, et al. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am. J. Hum. Genet. 2005;77:918–936
  16. Farmer AE, McGuffin P, Gottesman II. Twin concordance for DSM-III schizophrenia. Scrutinizing the validity of the definition. Arch. Gen. Psychiatry. 1987;44:634–641
  17. Gershon ES, DeLisi LE, Hamovit J, Nurnberger JI, Maxwell ME, Schreiber J, et al. A controlled family study of chronic psychoses. Schizophrenia and schizoaffective disorder. Arch. Gen. Psychiatry. 1988;45:328–336
  18. Gershon ES, Hamovit J, Guroff JJ, Dibble E, Leckman JF, Sceery W, et al. A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Arch. Gen. Psychiatry. 1982;39:1157–1167
  19. Goldberg TE, Straub RE, Callicott JH, Hariri A, Mattay VS, Bigelow L, et al. The G72/G30 gene complex and cognitive abnormalities in schizophrenia. Neuropsychopharmacology. 2006;31:2022–2032
  20. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry. 2003;160:636–645
  21. Hall D, Gogos JA, Karayiorgou M. The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations. Genes Brain Behav. 2004;3:240–248
  22. Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK. Toward constructing an endophenotype strategy for bipolar disorders. Biol. Psychiatry. 2006;60:93–105
  23. Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, et al. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am. J. Hum. Genet. 2003;72:1131–1140
  24. Hong CJ, Hou SJ, Yen FC, Liou YJ, Tsai SJ. Family-based association study between G72/G30 genetic polymorphism and schizophrenia. NeuroReport. 2006;17:1067–1069
  25. Kazeem GR, Farrall M. Integrating case-control and TDT studies. Ann. Hum. Genet. 2005;69:329–335
  26. Kendell RE. Diagnosis and classification of functional psychoses. Br. Med. Bull. 1987;43:499–513
  27. Kendler KS. Kraepelin and the differential diagnosis of dementia praecox and manic-depressive insanity. Compr. Psychiatry. 1986;27:549–558
  28. Kendler KS, Masterson CC, Davis KL. Psychiatric illness in first-degree relatives of patients with paranoid psychosis, schizophrenia and medical illness. Br. J. Psychiatry. 1985;147:524–531
  29. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. The Roscommon family study. IV. Affective illness, anxiety disorders, and alcoholism in relatives. Arch. Gen. Psychiatry. 1993;50:952–960
  30. Korostishevsky M, Kaganovich M, Cholostoy A, Ashkenazi M, Ratner Y, Dahary D, et al. Is the G72/G30 locus associated with schizophrenia? Single nucleotide polymorphisms, haplotypes, and gene expression analysis. Biol. Psychiatry. 2004;56:169–176
  31. Korostishevsky M, Kremer I, Kaganovich M, Cholostoy A, Murad I, Muhaheed M, et al. Transmission disequilibrium and haplotype analyses of the G72/G30 locus: suggestive linkage to schizophrenia in Palestinian Arabs living in the North of Israel. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006;141:91–95
  32. Kraepelin E. Manic-Depressive Insanity and Paranoia. Livingstone: Edinburgh; 1919;
  33. Kravariti E, Dixon T, Frith C, Murray R, McGuire P. Association of symptoms and executive function in schizophrenia and bipolar disorder. Schizophr. Res. 2005;74:221–231
  34. Li D, He L. G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies. Genetics. 2007;175:917–922
  35. Liu YL, Fann CS, Liu CM, Chang CC, Wu JY, Hung SI, et al. No association of G72 and d-amino acid oxidase genes with schizophrenia. Schizophr. Res. 2006;87:15–20
  36. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet. 2003;33:177–182
  37. Ma J, Qin W, Wang XY, Guo TW, Bian L, Duan SW, et al. Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations. Mol. Psychiatry. 2006;11:479–487
  38. Macaskill P, Walter SD, Irwig L. A comparison of methods to detect publication bias in meta-analysis. Stat. Med. 2001;20:641–654
  39. Maier W, Hofgen B, Zobel A, Rietschel M. Genetic models of schizophrenia and bipolar disorder: overlapping inheritance or discrete genotypes?. Eur. Arch. Psychiatry Clin. Neurosci. 2005;255:159–166
  40. Maier W, Lichtermann D, Minges J, Hallmayer J, Heun R, Benkert O, et al. Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family study. Arch. Gen. Psychiatry. 1993;50:871–883
  41. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst. 1959;22:719–748
  42. Martinez-Aran A, Penades R, Vieta E, Colom F, Reinares M, Benabarre A, et al. Executive function in patients with remitted bipolar disorder and schizophrenia and its relationship with functional outcome. Psychother. Psychosom. 2002;71:39–46
  43. Mulle JG, Chowdari KV, Nimgaonkar V, Chakravarti A. No evidence for association to the G72/G30 locus in an independent sample of schizophrenia families. Mol. Psychiatry. 2005;10:431–433
  44. Munafo MR, Thiselton DL, Clark TG, Flint J. Association of the NRG1 gene and schizophrenia: a meta-analysis. Mol. Psychiatry. 2006;11:539–546
  45. Nicodemus KK, Kolachana BS, Vakkalanka R, Straub RE, Giegling I, Egan MF, et al. Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. Hum. Genet. 2007;120:889–906
  46. Potash JB. Carving chaos: genetics and the classification of mood and psychotic syndromes. Harv. Rev. Psychiatry. 2006;14:47–63
  47. Schulze TG, Ohlraun S, Czerski PM, Schumacher J, Kassem L, Deschner M, et al. Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes. Am. J. Psychiatry. 2005;162:2101–2108
  48. Schumacher J, Jamra RA, Freudenberg J, Becker T, Ohlraun S, Otte AC, et al. Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol. Psychiatry. 2004;9:203–207
  49. Seidman LJ, Kremen WS, Koren D, Faraone SV, Goldstein JM, Tsuang MT. A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophr. Res. 2002;53:31–44
  50. Shih RA, Belmonte PL, Zandi PP. A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. Int. Rev. Psychiatry. 2004;16:260–283
  51. Topol EJ, Frazer KA. The resequencing imperative. Nat. Genet. 2007;39:439–440
  52. Van OJ, Gilvarry C, Bale R, Van HE, Tattan T, White I, et al. A comparison of the utility of dimensional and categorical representations of psychosis. UK700 Group. Psychol. Med. 1999;29:595–606
  53. Vilella, E., Costas, J., Sanjuan, J., Guitart, M., De, D.Y., Carracedo, A., Martorell, L., Valero, J., Labad, A., De, F.R., Najera, C., Molto, M.D., Toirac, I., Guillamat, R., Brunet, A., Valles, V., Perez, L., Leon, M., de Fonseca, F.R., Phillips, C., Torres, M., in press. Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction. J. Psychiatr. Res. (Electronic publication ahead of print).
  54. Wang X, He G, Gu N, Yang J, Tang J, Chen Q, et al. Association of G72/G30 with schizophrenia in the Chinese population. Biochem. Biophys. Res. Commun. 2004;319:1281–1286
  55. Williams NM, Green EK, MacGregor S, Dwyer S, Norton N, Williams H, et al. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Arch. Gen. Psychiatry. 2006;63:366–373
  56. Wood LS, Pickering EH, Dechairo BM. Significant support for DAO as a schizophrenia susceptibility locus: examination of five genes putatively associated with schizophrenia. Biol. Psychiatry. 2007;61:1195–1199
  57. Yue W, Kang G, Zhang Y, Qu M, Tang F, Han Y, et al. Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects. Neurosci. Lett. 2007;416:96–100
  58. Yue W, Liu Z, Kang G, Yan J, Tang F, Ruan Y, et al. Association of G72/G30 polymorphisms with early-onset and male schizophrenia. NeuroReport. 2006;17:1899–1902
  59. Zou F, Li C, Duan S, Zheng Y, Gu N, Feng G, et al. A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population. Schizophr. Res. 2005;73:257–261

PII: S0920-9964(07)00457-4

doi: 10.1016/j.schres.2007.10.004

Schizophrenia Research
Volume 98, Issue 1 , Pages 89-97 , January 2008

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