Schizophrenia Research
Volume 98, Issue 1 , Pages 111-117 , January 2008

Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection

  • Rajiv P. Sharma

      Affiliations

    • The Psychiatric Institute, University of Illinois at Chicago, 1601 W. Taylor St., Chicago, IL 60612, United States
    • Department of Psychiatry, University of Illinois at Chicago—College of Medicine, 912 S. Wood St., Chicago, IL 60612, United States
    • Corresponding Author InformationCorresponding author. The Psychiatric Institute 1601 West Taylor Street Chicago, IL 60612, United States. Tel.: +1 312 413 4508; fax: +1 312 413 4503.
    • ,
  • Dennis R. Grayson

      Affiliations

    • The Psychiatric Institute, University of Illinois at Chicago, 1601 W. Taylor St., Chicago, IL 60612, United States
    • Department of Psychiatry, University of Illinois at Chicago—College of Medicine, 912 S. Wood St., Chicago, IL 60612, United States
    • ,
  • David P. Gavin

      Affiliations

    • The Psychiatric Institute, University of Illinois at Chicago, 1601 W. Taylor St., Chicago, IL 60612, United States
    • Department of Psychiatry, University of Illinois at Chicago—College of Medicine, 912 S. Wood St., Chicago, IL 60612, United States

Received 27 June 2007 ,Revised 10 September 2007 ,Accepted 14 September 2007.

References 

  1. Abdolmaleky HM, Cheng KH, Russo A, Smith CL, Faraone SV, Wilcox M, et al. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005;134(1):60–66
  2. Abdolmaleky HM, Cheng KH, Faraone SV, Wilcox M, Glatt SJ, Gao F, et al. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum. Mol. Genet. 2006;15(21):3132–3145
  3. Akbarian S, Ruehl MG, Bliven E, Luiz LA, Peranelli AC, Baker SP, et al. Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia. Arch. Gen. Psychiatry. 2005;62(8):829–840
  4. Akbarian S, Huang HS. Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain Res. Brain Res. Rev. 2006;52(2):293–304
  5. Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER, et al. Chromatin acetylation, memory, and LTP are impaired in CBP+/− mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron. 2004;42(6):947–959
  6. Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M. Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc. Natl. Acad. Sci. U. S. A. 2007;104(24):10164–10169
  7. Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC, et al. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science. 2003;302(5646):885–889
  8. Chen Y, Sharma RP, Costa RH, Costa E, Grayson DR. On the epigenetic regulation of human reelin promoter. Nucleic Acids Res. 2002;30(13):2930–2939
  9. Costa E, Grayson DR, Veldic M, Guidotti A. Neurochemical basis for an epigenetic vision of synaptic organization. Int. Rev. Neurobiol. 2004;59:73–91
  10. Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2005;102(35):12578–12583
  11. Fan G, Beard C, Chen RZ, Csankovszki G, Sun Y, Siniaia M, et al. DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J. Neurosci. 2001;21(3):788–797
  12. Gavin DP, Rosen C, Jayaraman S, Grayson D, Sharma RP. HDAC inhibitors, valproic acid and trichostatin A increase glutamic acid decarboxylase (GAD67) expression in primary lymphocyte cultures. Biol. Psychiatry. 2007;61(8S):210S
  13. Gibbons RD, Bhaumik DK, Cox DR, Grayson DR, Davis JM, Sharma RP. Sequential prediction bounds for identifying differentially expressed genes in replicated microarray experiments. J. Stat. Plan. Inference. 2005;129:19–37
  14. Guidotti A, Ruzicka W, Grayson DR, Veldic M, Pinna G, Davis JM, et al. S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis. NeuroReport. 2007;18(1):57–60
  15. Grayson DR, Jia X, Chen Y, Sharma RP, Mitchell CP, Guidotti A, et al. Reelin promoter hypermethylation in schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2005;102(26):9341–9346
  16. Korzus E, Rosenfeld MG, Mayford M. CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron. 2004;42(6):961–972
  17. Kundakovic M, Chen Y, Costa E, Grayson DR. DNA methyltransferase inhibitors coordinately induce expression of the human reelin and GAD67 genes. Mol. Pharmacol. 2006;71(3):644–653
  18. Levenson JM, Roth TL, Lubin FD, Miller CA, Huang IC, Desai P, et al. Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. J. Biol. Chem. 2006;281(23):15763–15773
  19. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, et al. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. 2003;302(5646):890–893
  20. Miller CA, Sweatt JD. Covalent modification of DNA regulates memory formation. Neuron. 2007;53(6):857–869
  21. Noh JS, Sharma RP, Veldic M, Salvacion AA, Jia X, Chen Y, et al. DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures. Proc. Natl. Acad. Sci. U. S. A. 2005;102(5):1749–1754
  22. Petronis A, Paterson AD, Kennedy JL. Schizophrenia: an epigenetic puzzle?. Schizophr. Bull. 1999;25(4):639–655
  23. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem. J. 2003;370(Pt 3):737–749
  24. Ruzicka WB, Zhubi A, Veldic M, Grayson DR, Costa E, Guidotti A. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Mol. Psychiatry. 2007;12(4):385–397
  25. Saha RN, Pahan K. HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis. Cell Death Differ. 2006;13(4):539–550
  26. Sharma RP. Schizophrenia, epigenetics and ligand-activated nuclear receptors: a framework for chromatin therapeutics. Schizophr. Res. 2005;72(2–3):79–90
  27. Sharma RP, Grayson DR, Guidotti A, Costa E. Chromatin, DNA methylation, and neuron gene regulation — the purpose of the package. J. Psychiatry Neurosci. 2005;30(4):257–263
  28. Sharma RP, Rosen CR, Kartan S, Guidotti A, Costa E, Grayson D, et al. Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population. Schizophr. Res. 2006;88(1–3):227–231
  29. Sharma, R.P., Tun, N., Kartan, S., Grayson, D.R., 2007. DNA methyltransferase activity in primary cortical cultures. Society of Neuroscience meeting, San Diego, CA 2007. Abstract 607.16/HH6.
  30. Simonini MV, Camargo LM, Dong E, Maloku E, Veldic M, Costa E, et al. The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases. Proc. Natl. Acad. Sci. U. S. A. 2006;103(5):1587–1592
  31. Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting P, et al. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc. Natl. Acad. Sci. U. S. A. 2002;99(26):17095–17100
  32. Tremolizzo L, Doueiri MS, Dong E, Grayson DR, Davis J, Pinna G, et al. Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol. Psychiatry. 2005;57(5):500–509
  33. Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat. Neurosci. 2006;9(4):519–525
  34. Veldic M, Caruncho HJ, Liu WS, Davis J, Satta R, Grayson DR, et al. DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains. Proc. Natl. Acad. Sci. U. S. A. 2004;101(1):348–353
  35. Veldic M, Guidotti A, Maloku E, Davis JM, Costa E. In psychosis, cortical interneurons overexpress DNA-methyltransferase 1. Proc. Natl. Acad. Sci. U. S. A. 2005;102(6):2152–2157
  36. Veldic M, Kadriu B, Maloku E, Agis-Balboa RC, Guidotti A, Davis JM, et al. Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder. Schizophr. Res. 2007;91(1–3):51–61

☆ This work was presented at the Society of Biological Psychiatry meeting in San Diego, May 2007.

PII: S0920-9964(07)00428-8

doi: 10.1016/j.schres.2007.09.020

Schizophrenia Research
Volume 98, Issue 1 , Pages 111-117 , January 2008

Article Tools

* Image Usage & Resolution