Schizophrenia Research
Volume 96, Issue 1 , Pages 82-86 , November 2007

Structural changes to the fusiform gyrus: A cerebral marker for social impairments in 22q11.2 deletion syndrome?

  • Bronwyn Glaser

      Affiliations

    • Service Médico-Pédagogique, Department of Child Psychiatry, University of Geneva Medical School and University Hospitals, 16-18 bd St Georges, 1211 Geneva 8, Switzerland
    • Corresponding Author InformationCorresponding author. Service médico-pédagogique, Bd St-Georges 16-18, Case postale 50, CH-1211 Geneva 8, Switzerland. Tel.: +41 22 327 43 02; fax: +41 22 327 43 20.
    • ,
  • Marie Schaer

      Affiliations

    • Service Médico-Pédagogique, Department of Child Psychiatry, University of Geneva Medical School and University Hospitals, 16-18 bd St Georges, 1211 Geneva 8, Switzerland
    • Signal Processing Institute, EPFL, LT55, Station 11, 1011 Lausanne, Switzerland
    • ,
  • Sandra Berney

      Affiliations

    • Service Médico-Pédagogique, Department of Child Psychiatry, University of Geneva Medical School and University Hospitals, 16-18 bd St Georges, 1211 Geneva 8, Switzerland
    • ,
  • Martin Debbane

      Affiliations

    • Service Médico-Pédagogique, Department of Child Psychiatry, University of Geneva Medical School and University Hospitals, 16-18 bd St Georges, 1211 Geneva 8, Switzerland
    • ,
  • Patrik Vuilleumier

      Affiliations

    • Behavioral Neurology and Imaging of Cognition, Clinic of Neurology, University Hospital and Department of Neurosciences, University Medical Center, Switzerland
    • Swiss National Center of Affective Sciences, University of Geneva, Switzerland
    • ,
  • Stephan Eliez

      Affiliations

    • Service Médico-Pédagogique, Department of Child Psychiatry, University of Geneva Medical School and University Hospitals, 16-18 bd St Georges, 1211 Geneva 8, Switzerland
    • Department of Genetic Medicine and Development, University of Geneva Medical School and University Hospitals, Switzerland

Received 22 May 2007 ,Revised 9 August 2007 ,Accepted 15 August 2007.

References 

  1. Adolphs R. Cognitive neuroscience of human social behaviour. Nat. Rev., Neurosci. 2003;4(3):165–178
  2. Andersson, F., Glaser, B., Spiridon, M., Debbane, M., Lazeyras, F., Delavelle, J., Vuilleumier, P., Eliez, S., in press. Impaired activation of face processing networks revealed by fMRI in 22q11.2 deletion syndrome. Biological Psychiatry (Jul 23 2007, Electronic publication ahead of print).
  3. Baker KD, Skuse DH. Adolescents and young adults with 22q11 deletion syndrome: psychopathology in an at-risk group. Br. J. Psychiatry. 2005;186:115–120
  4. Barnea-Goraly N, Menon V, Krasnow B, Ko A, Reiss A, Eliez S. Investigation of white matter structure in velocardiofacial syndrome: a diffusion tensor imaging study. Am. J. Psychiatry. 2003;160(10):1863–1869
  5. Behrmann M, Avidan G, Leonard GL, Kimchi R, Luna B, Humphreys K, et al. Configural processing in autism and its relationship to face processing. Neuropsychologia. 2006;44(1):110–129
  6. Belmonte MK, Allen G, Beckel-Mitchener A, Boulanger LM, Carper RA, Webb SJ. Autism and abnormal development of brain connectivity. J. Neurosci. 2004;24(42):9228–9231
  7. Debbane M, Glaser B, David MK, Feinstein C, Eliez S. Psychotic symptoms in children and adolescents with 22q11.2 deletion syndrome: neuropsychological and behavioral implications. Schizophr. Res. 2006;84(2-3):187–193
  8. Debbane M, Schaer M, Farhoumand R, Glaser B, Eliez S. Hippocampal volume reduction in 22q11.2 deletion syndrome. Neuropsychologia. 2006;44(12):2360–2365
  9. Duvernoy HM. The Human Brain: Surface, Three-Dimensional Sectional Anatomy and MRI. Series. New York: Springer-Verlag Wien; 1991;
  10. Eliez S, Schmitt JE, White CD, Reiss AL. Children and adolescents with velocardiofacial syndrome: a volumetric MRI study. Am. J. Psychiatry. 2000;157(3):409–415
  11. Eliez S, Blasey CM, Menon V, White CD, Schmitt JE, Reiss AL. Functional brain imaging study of mathematical reasoning abilities in velocardiofacial syndrome (del22q11.2). Genet. Med. 2001;3(1):49–55
  12. Eliez S, Blasey CM, Schmitt EJ, White CD, Hu D, Reiss AL. Velocardiofacial syndrome: are structural changes in the temporal and mesial temporal regions related to schizophrenia?. Am. J. Psychiatry. 2001;158(3):447–453
  13. Glaser B, Debbane M, Schaer M, Martinez S, Berney S, Andersson F, et al. What can face processing tell us about cognitive and social development in VCFS?. In: 12th Annual International Scientific Meeting of the Velo-Cardio-Facial Syndrome Educational Foundation. 2006;Strasbourg, France
  14. Grossmann T, Johnson MH. The development of the social brain in human infancy. Eur. J. Neurosci. 2007;25(4):909–919
  15. Gur RE, McGrath C, Chan RM, Schroeder L, Turner T, Turetsky BI, et al. An fMRI study of facial emotion processing in patients with schizophrenia. Am. J. Psychiatry. 2002;159(12):1992–1999
  16. Haxby JV, Hoffman EA, Gobbini MI. The distributed human neural system for face perception. Trends Cogn. Sci. 2000;4(6):223–233
  17. Kanwisher N, McDermott J, Chun MM. The fusiform face area: a module in human extrastriate cortex specialized for face perception. J. Neurosci. 1997;17(11):4302–4311
  18. Karayiorgou M, Morris MA, Morrow B, Shprintzen RJ, Goldberg R, Borrow J, et al Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc. Natl. Acad. Sci. U S A. 1995;92(17):7612–7616
  19. Kates WR, Burnette CP, Jabs EW, Rutberg J, Murphy AM, Grados M, et al. Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis. Biol. Psychiatry. 2001;49(8):677–684
  20. Kates WR, Miller AM, Abdulsabur N, Antshel KM, Conchelos J, Fremont W, et al. Temporal lobe anatomy and psychiatric symptoms in velocardiofacial syndrome (22q11.2 deletion syndrome). J. Am. Acad. Child Adolesc. Psych. 2006;45(5):587–595
  21. Kim JJ, Crespo-Facorro B, Andreasen NC, O'Leary DS, Zhang B, Harris G, et al. An MRI-based parcellation method for the temporal lobe. NeuroImage. 2000;11(4):271–288
  22. Lajiness-O'Neill RR, Beaulieu I, Titus JB, Asamoah A, Bigler ED, Bawle EV, et al. Memory and learning in children with 22q11.2 deletion syndrome: evidence for ventral and dorsal stream disruption?. Child Neuropsychol. 2005;11(1):55–71
  23. Lee CU, Shenton ME, Salisbury DF, Kasai K, Onitsuka T, Dickey CC, et al. Fusiform gyrus volume reduction in first-episode schizophrenia: a magnetic resonance imaging study. Arch. Gen. Psychiatry. 2002;59(9):775–781
  24. Schaer M, Schmitt JE, Glaser B, Lazeyras F, Delavelle J, Eliez S. Abnormal patterns of cortical gyrification in velo-cardio-facial syndrome (deletion 22q11.2): an MRI study. Psychiatry Res. 2006;146(1):1–11
  25. Simon TJ, Ding L, Bish JP, McDonald-McGinn DM, Zackai EH, Gee J. Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study. NeuroImage. 2005;25(1):169–180
  26. Surguladze S, Brammer MJ, Keedwell P, Giampietro V, Young AW, Travis MJ, et al. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biol. Psychiatry. 2005;57(3):201–209
  27. Takahashi T, Suzuki M, Zhou SY, Tanino R, Hagino H, Niu L, et al. Temporal lobe gray matter in schizophrenia spectrum: a volumetric MRI study of the fusiform gyrus, parahippocampal gyrus, and middle and inferior temporal gyri. Schizophr. Res. 2006;87(1-3):116–126
  28. van Amelsvoort T, Daly E, Robertson D, Suckling J, Ng V, Critchley H, et al. Structural brain abnormalities associated with deletion at chromosome 22q11: quantitative neuroimaging study of adults with velo-cardio-facial syndrome. Br. J. Psychiatry. 2001;178:412–419
  29. van Amelsvoort T, Schmitz N, Daly E, Deeley Q, Critchley H, Henry J, et al. Processing facial emotion in adults with velo-cardio-facial syndrome: functional magnetic resonance imaging. Br. J. Psychiatry. 2006;189:560–561
  30. Waiter GD, Williams JH, Murray AD, Gilchrist A, Perrett DI, Whiten A. A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder. NeuroImage. 2004;22(2):619–625
  31. Young MP. Objective analysis of the topological organization of the primate cortical visual system. Nature. 1992;358(6382):152–155
  32. Zinkstok J, van Amelsvoort T. Neuropsychological profile and neuroimaging in patients with 22Q11.2 Deletion Syndrome: a review. Neuropsychol. Dev. Cogn., Sect. C, Child Neuropsychol. 2005;11(1):21–37

PII: S0920-9964(07)00376-3

doi: 10.1016/j.schres.2007.08.016

Schizophrenia Research
Volume 96, Issue 1 , Pages 82-86 , November 2007

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