Schizophrenia Research
Volume 96, Issue 1 , Pages 100-111 , November 2007

Association of synapsin 2 with schizophrenia in families of Northern European ancestry

Received 26 March 2007 ,Revised 27 July 2007 ,Accepted 31 July 2007.

References 

  1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat. Genet. 2002;30(1):97–101
  2. Ahmadian A, Gharizadeh B, Gustafsson AC, Sterky F, Nyren P, Uhlen M, et al. Single-nucleotide polymorphism analysis by pyrosequencing. Anal. Biochem. 2000;280(1):103–110
  3. Augustine GJ, Burns ME, DeBello WM, Hilfiker S, Morgan JR, Schweizer FE, et al. Proteins involved in synaptic vesicle trafficking. J. Physiol. 1999;520(Pt 1):33–41
  4. Bassett AS, Chow EWC, Waterworth DM, Brzustowicz L. Genetic insights into schizophrenia. Can. J. Psychiatry. 2001;46(2):131–137
  5. Bassett AS, Chow EW, Weksberg R, Brzustowicz L. Schizophrenia and genetics: new insights. Curr. Psychiatry Rep. 2002;4(4):307–314
  6. Bortolin S, Black M, Modi H, Boszko I, Kobler D, Fieldhouse D, et al. Analytical validation of the tag-it high-throughput microsphere-based universal array genotyping platform: application to the multiplex detection of a panel of thrombophilia-associated single-nucleotide polymorphisms. Clin. Chem. 2004;50(11):2028–2036
  7. Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science. 2000;288(5466):678–682
  8. Brzustowicz LM, Hayter JE, Hodgkinson KA, Chow EWC, Bassett AS. Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22. Hum. Hered. 2002;54(4):199–209
  9. Brzustowicz LM, Simone J, Mohseni P, Hayter JE, Hodgkinson KA, Chow EWC, et al. Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22. Am. J. Hum. Genet. 2004;74(5):1057–1063
  10. Chen Q, He G, Qin W, Chen QY, Zhao XZ, Duan SW, et al. Family-based association study of synapsin II and schizophrenia. Am. J. Hum. Genet. 2004;75(5):873–877
  11. Chen Q, He G, Wang XY, Chen QY, Liu XM, Gu ZZ, et al. Positive association between synapsin II and schizophrenia. Biol. Psychiatry. 2004;56(3):177–181
  12. Chong VZ, Young LT, Mishra RK. cDNA array reveals differential gene expression following chronic neuroleptic administration: implications of synapsin II in haloperidol treatment. J. Neurochem. 2002;82(6):1533–1539
  13. Chong VZ, Skoblenick K, Morin F, Xu Y, Mishra RK. Dopamine-D1 and -D2 receptors differentially regulate synapsin II expression in the rat brain. Neuroscience. 2006;138(2):587–599
  14. Clayton D. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am. J. Hum. Genet. 1999;65(4):1170–1177
  15. Cloninger CR, Kaufmann CA, Faraone SV, Malaspina D, Svrakic DM, Harkavy-Friedman J, et al. Genome-wide search for schizophrenia susceptibility loci: the NIMH genetics initiative and millennium consortium. Am. J. Med. Genet. 1998;81(4):275–281
  16. Cottingham RW, Idury RM, Schaffer AA. Faster sequential genetic linkage computations. Am. J. Hum. Genet. 1993;53(1):252–263
  17. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 2003;25(2):115–121
  18. Durner M, Vieland VJ, Greenberg DA. Further evidence for the increased power of LOD scores compared with nonparametric methods. Am. J. Hum. Genet. 1999;64(1):281–289
  19. Faraone SV, Blehar M, Pepple J, Moldin SO, Norton J, Nurnberger JI, et al. Diagnostic accuracy and confusability analyses: an application to the diagnostic interview for genetic studies. Psychol. Med. 1996;26(2):401–410
  20. Gitler D, Takagishi Y, Feng J, Ren Y, Rodriguiz RM, Wetsel WC, et al. Different presynaptic roles of synapsins at excitatory and inhibitory synapses. J. Neurosci. 2004;24(50):11368–11380
  21. Greengard P, Valtorta F, Czernik AJ, Benfenati F. Synaptic vesicle phosphoproteins and regulation of synaptic function. Science. 1993;259(5096):780–785
  22. Hilfiker S, Pieribone VA, Czernik AJ, Kao HT, Augustine GJ, Greengard P. Synapsins as regulators of neurotransmitter release. Philos. Trans. R. Soc. Lond., B Biol. Sci. 1999;354(1381):269–279
  23. Hilfiker S, Benfenati F, Doussau F, Nairn AC, Czernik AJ, Augustine GJ, et al. Structural domains involved in the regulation of transmitter release by synapsins. J. Neurosci. 2005;25(10):2658–2669
  24. Hosaka M, Sudhof TC. Synapsins I and II are ATP-binding proteins with differential Ca2+ regulation. J. Biol. Chem. 1998;273(3):1425–1429
  25. Hung CC, Chen YH, Tsai MT, Chen CH. Systematic search for mutations in the human tissue inhibitor of metalloproteinases-3 (TIMP-3) gene on chromosome 22 and association study with schizophrenia. Am. J. Med. Genet. 2001;105(3):275–278
  26. Iannone MA, Taylor JD, Chen J, Li MS, Rivers P, Slentz-Kesler KA, et al. Multiplexed single nucleotide polymorphism genotyping by oligonucleotide ligation and flow cytometry. Cytometry. 2000;39(2):131–140
  27. Imai C, Sugai T, Iritani S, Niizato K, Nakamura R, Makifuchi T, et al. A quantitative study on the expression of synapsin II and N-ethylmaleimide-sensitive fusion protein in schizophrenic patients. Neurosci. Lett. 2001;305(3):185–188
  28. Jaffrey SR, Benfenati F, Snowman AM, Czernik AJ, Snyder SH. Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. PNAS. 2002;99(5):3199–3204
  29. Kao HT, Porton B, Hilfiker S, Stefani G, Pieribone VA, DeSalle R, et al. Molecular evolution of the synapsin gene family. J. Exp. Zool. 1999;285(4):360–377
  30. Lee HJ, Song JY, Kim JW, Jin SY, Hong MS, Park JK, et al. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. Behav. Brain Funct. 2005;1:15
  31. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am. J. Hum. Genet. 2003;73(1):34–48
  32. Martin ER, Monks SA, Warren LL, Kaplan NL. A test for linkage and association in general pedigrees: the pedigree disequilibrium test. Am. J. Hum. Genet. 2000;67(1):146–154
  33. McGuffin P, Asherson P, Owen M, Farmer A. The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia?. Br. J. Psychiatry. 1994;164(5):593–599
  34. Mirnics K, Middleton FA, Marquez A, Lewis DA, Levitt P. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron. 2000;28(1):53–67
  35. Mitchell AA, Cutler DJ, Chakravarti A. Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test. Am. J. Hum. Genet. 2003;72(3):598–610
  36. Nurnberger JI, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH genetics initiative. Arch. Gen. Psychiatry. 1994;51(11):849–859(discussion 863–844)
  37. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am. J. Hum. Genet. 1998;63(1):259–266
  38. Olson TM, Hirohata S, Ye J, Leco K, Seldin MF, Apte SS. Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively. Genomics. 1998;51(1):148–151
  39. Ott J. Linkage probability and its approximate confidence interval under possible heterogeneity. Genet. Epidemiol. Suppl. 1986;1:251–257
  40. Ott J. Computer-simulation methods in human linkage analysis. Proc. Natl. Acad. Sci. U. S. A. 1989;86(11):4175–4178
  41. Pohar N, Godenschwege TA, Buchner E. Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to human. Genomics. 1999;57(2):293–296
  42. Pulver AE, Lasseter VK, Kasch L, Wolyniec P, Nestadt G, Blouin JL, et al Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am. J. Med. Genet. 1995;60(3):252–260
  43. Ronaghi M, Uhlen M, Nyren P. A sequencing method based on real-time pyrophosphate. Science. 1998;281(5375):363–365
  44. Saviouk V, Chow EW, Bassett AS, Brzustowicz LM. Tumor necrosis factor promoter haplotype associated with schizophrenia reveals a linked locus on 1q44. Mol. Psychiatry. 2004;10(4):375–383
  45. Schaffer AA, Gupta SK, Shriram K, Cottingham RW. Avoiding recomputation in linkage analysis. Hum. Hered. 1994;44(4):225–237
  46. Sobel E, Lange K. Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am. J. Hum. Genet. 1996;58(6):1323–1337
  47. Sobel E, Sengul H, Weeks DE. Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees. Hum. Hered. 2001;52(3):121–131
  48. Sobel E, Papp JC, Lange K. Detection and integration of genotyping errors in statistical genetics. Am. J. Hum. Genet. 2002;70(2):496–508
  49. Vawter MP, Thatcher L, Usen N, Hyde TM, Kleinman JE, Freed WJ. Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia. Mol. Psychiatry. 2002;7(6):571–578
  50. Wang HY, Luo M, Tereshchenko IV, Frikker DM, Cui X, Li JY, et al. A genotyping system capable of simultaneously analyzing >1000 single nucleotide polymorphisms in a haploid genome. Genome Res. 2005;15(2):276–283
  51. Xu B, Wratten N, Charych EI, Buyske S, Firestein BL, Brzustowicz LM. Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder. PLoS Med. 2005;2(10):e263
  52. Zheng Y, Li H, Qin W, Chen W, Duan Y, Xiao Y, et al. Association of the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase gene with schizophrenia in the Chinese Han population. Biochem. Biophys. Res. Commun. 2005;328(4):809–815

PII: S0920-9964(07)00332-5

doi: 10.1016/j.schres.2007.07.031

Schizophrenia Research
Volume 96, Issue 1 , Pages 100-111 , November 2007

Article Tools