No association between the DRD3 Ser9Gly polymorphism and schizophrenia

Received 11 January 2007; received in revised form 1 July 2007; accepted 4 July 2007. published online 15 August 2007.

Abstract

Objective

To investigate the association between a Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) and schizophrenia.

Methods

408 schizophrenic patients and 172 control subjects were compared with regard to their DRD3 Ser9Gly genotypic and allelic frequencies. In addition, we carried out a family-based association study including 183 pedigrees (472 subjects) using the transmission disequilibrium test (TDT).

Results

No significant differences of genotype or homozygosity distribution were identified between patients and controls. When patients were stratified according to gender, response to treatment, age at onset, no significant differences were observed. Neither allele A (Ser), or G (Gly) were preferentially transmitted from parents to affected offspring.

Conclusion

The hypothesis that the DRD3 Ser9Gly polymorphism plays a predisposing role in schizophrenia is not supported by this study.

Keywords: Schizophrenia, DRD3 (dopamine D3 receptor gene), Association study, Neuroleptic response

a Douglas Hospital Research Centre, Montréal, Québec, Canada

b Montréal University, Montréal, Québec, Canada

c Notre Dame Hospital Research Centre (CHUM), Montréal, Québec, Canada

d Department of Psychiatry, University of Tunis, Tunisia

e Department of Psychiatry, McGill University, Montréal, Québec, Canada

f National Institute of Psychiatry, Budapest, Hungary

Corresponding author. Douglas Hospital Research Center 6875, Boul LaSalle Verdun, Quebec, Canada H4H 1R3; Department of Psychiatry, McGill University, Montréal, Québec, Canada. Tel.: +1 514 762 3048; fax: +1 514 888 4064.

PII: S0920-9964(07)00300-3

doi:10.1016/j.schres.2007.07.002

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