No association between the DRD3 Ser9Gly polymorphism and schizophrenia

Fathalli, Ferid; Rouleau, Guy A.; Xiong, Lan; Tabbane, Karim; Benkelfat, Chawki; Deguzman, Rosherrie; Zoltan, Danics; Lal, Samarthji; D’cruz, Sarogini; Joober, Ridha

doi:10.1016/j.schres.2007.07.002

« Previous Next »Schizophrenia Research
Volume 98, Issue 1 , Pages 98-104, January 2008

No association between the DRD3 Ser9Gly polymorphism and schizophrenia

Ferid Fathalli
- Douglas Hospital Research Centre, Montréal, Québec, Canada
- Montréal University, Montréal, Québec, Canada
Guy A. Rouleau
- Montréal University, Montréal, Québec, Canada
- Notre Dame Hospital Research Centre (CHUM), Montréal, Québec, Canada
Lan Xiong
- Notre Dame Hospital Research Centre (CHUM), Montréal, Québec, Canada
Karim Tabbane
- Department of Psychiatry, University of Tunis, Tunisia
Chawki Benkelfat
- Department of Psychiatry, McGill University, Montréal, Québec, Canada
Rosherrie Deguzman
- Douglas Hospital Research Centre, Montréal, Québec, Canada
Danics Zoltan
- National Institute of Psychiatry, Budapest, Hungary
Samarthji Lal
- Douglas Hospital Research Centre, Montréal, Québec, Canada
- Department of Psychiatry, McGill University, Montréal, Québec, Canada
Sarogini D’cruz
- Douglas Hospital Research Centre, Montréal, Québec, Canada
Ridha Joober
- Douglas Hospital Research Centre, Montréal, Québec, Canada
- Department of Psychiatry, McGill University, Montréal, Québec, Canada
- Corresponding author. Douglas Hospital Research Center 6875, Boul LaSalle Verdun, Quebec, Canada H4H 1R3; Department of Psychiatry, McGill University, Montréal, Québec, Canada. Tel.: +1 514 762 3048; fax: +1 514 888 4064.

Received 11 January 2007; received in revised form 1 July 2007; accepted 4 July 2007. published online 15 August 2007.

Abstract

Objective

To investigate the association between a Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) and schizophrenia.

Methods

408 schizophrenic patients and 172 control subjects were compared with regard to their DRD3 Ser9Gly genotypic and allelic frequencies. In addition, we carried out a family-based association study including 183 pedigrees (472 subjects) using the transmission disequilibrium test (TDT).

Results

No significant differences of genotype or homozygosity distribution were identified between patients and controls. When patients were stratified according to gender, response to treatment, age at onset, no significant differences were observed. Neither allele A (Ser), or G (Gly) were preferentially transmitted from parents to affected offspring.