Schizophrenia Research
Volume 98, Issue 1 , Pages 105-110 , January 2008

Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients

  • Cynthia Shannon Weickert

      Affiliations

    • MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    • Schizophrenia Research Institute, Prince of Wales Medical Research Institute, University of New South Wales, Australia and IRP, NIMH, NIH, Bethesda, MD 20892, USA
    • Corresponding Author InformationCorresponding author. UNSW Department of Psychiatry, Prince of Wales Medical Research Institute, Barker Street Randwick, NSW 2031 Australia. Tel.: +61 2 9399 1117; fax: +61 2 9399 1005.
    • ,
  • Debora A. Rothmond

      Affiliations

    • MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    • ,
  • Thomas M. Hyde

      Affiliations

    • Neuropathology Section of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    • ,
  • Joel E. Kleinman

      Affiliations

    • Neuropathology Section of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    • ,
  • Richard E. Straub

      Affiliations

    • Genes of Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA

Received 15 March 2007 ,Revised 13 May 2007 ,Accepted 16 May 2007.

References 

  1. Bray NJ, Buckland PR, Owen MJ, O'Donovan MC. Cis-acting variation in the expression of a high proportion of gene in human brain. Hum. Genet. 2003;113:149–153
  2. Bray NJ, Preece A, Williams NM, Moskvina V, Buckland PR, Owen MJ, et al. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Hum. Mol. Genet. 2005;14:1947–1954
  3. Chiba S, Hashimoto R, Hattori S, Yohda M, Lipska B, Weinberger DR, et al. Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus. J. Neural Transm. 2006;113:1337–1346
  4. Eastwood SL, Burnet PW, McDonald B, Clinton J, Harrison PJ. Synaptophysin gene expression in human brain: a quantitative in situ hybridization and immunocytochemical study. Neuroscience. 1994;59:881–892
  5. Harrison PJ. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology (Berl). 2004;174:151–162
  6. Harrison PJ, Eastwood SL. Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia. Hippocampus. 2001;11:508–519
  7. Harrison PJ, Law AJ, Eastwood SL. Glutamate receptors and transporters in the hippocampus in schizophrenia. Ann. N. Y. Acad. Sci. 2003;1003:94–101
  8. Law AJ, Weickert CS, Hyde TM, Kleinman JE, Harrison PJ. Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines. Am. J. Psychiatry. 2004;161:1848–1855
  9. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, et al. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum. Mol. Genet. 2004;13:2699–2708
  10. Riley B, Kendler KS. Molecular genetic studies of schizophrenia. Eur. J. Hum. Genet. 2006;14:669–680
  11. Schwab SG, Knapp M, Mondabon S, Hallmayer J, Borrmann-Hassenbach M, Albus M, et al. Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am. J. Hum. Genet. 2003;72:185–190
  12. Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV, et al. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am. J. Hum. Genet. 2002;71:337–348
  13. Talbot K, Eidem WL, Tinsley CL, Benson MA, Thompson EW, Smith RJ, et al. Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. J. Clin. Invest. 2004;113:1353–1363
  14. Talbot K, Cho D, Ong W, Kazi HA, Siegel SJ, Blake DJ, et al. Sandy (Sdy) Mice Display Both a Loss of Dysbindin and Elevated Vesicular Glutamate Transporter-1 (VGlut-1) in the Same Synaptic Fields of the Hippocampal Formation. 2005;
  15. Talbot K, Cho DS, Ong WY, Benson MA, Han LY, Kazi HA, et al. Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin. Hum. Mol. Genet. 2006;15:3041–3054
  16. Webster MJ, Shannon Weickert C, Herman MM, Hyde TM, Kleinman JE. Synaptophysin and GAP-43 mRNA levels in the hippocampus of subjects with schizophrenia. Schizophr. Res. 2001;49:89–98
  17. Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, et al. Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch. Gen. Psychiatry. 2004;61:544–555

PII: S0920-9964(07)00236-8

doi: 10.1016/j.schres.2007.05.041

Schizophrenia Research
Volume 98, Issue 1 , Pages 105-110 , January 2008

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