Schizophrenia Research
Volume 92, Issue 1 , Pages 50-62 , May 2007

Premorbid adjustment in schizophrenia — An important aspect of phenotype definition

  • Christine Schmael

      Affiliations

    • Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, J5, D-68159 Mannheim, Germany
    • ,
  • Alexander Georgi

      Affiliations

    • Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, J5, D-68159 Mannheim, Germany
    • ,
  • Bertram Krumm

      Affiliations

    • Central Institute of Mental Health, Department of Biostatistics, J5, D-68159 Mannheim, Germany
    • ,
  • Christin Buerger

      Affiliations

    • Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, J5, D-68159 Mannheim, Germany
    • ,
  • Monika Deschner

      Affiliations

    • Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, J5, D-68159 Mannheim, Germany
    • ,
  • Markus M. Nöthen

      Affiliations

    • Life and Brain Center, Department of Genomics, University of Bonn, Sigmund Freud-Str. 25, D-53105 Bonn, Germany
    • Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, D-53111 Bonn, Germany
    • ,
  • Thomas G. Schulze

      Affiliations

    • Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, J5, D-68159 Mannheim, Germany
    • ,
  • Marcella Rietschel

      Affiliations

    • Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, J5, D-68159 Mannheim, Germany
    • Corresponding Author InformationCorresponding author. Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, P.O.B. 122120, D-68072 Mannheim, Germany. Tel.: +49 621 1703 6052; fax: +49 621 1703 6055.

Received 4 July 2006 ,Revised 30 January 2007 ,Accepted 30 January 2007.

References 

  1. Addington J, Addington D. Premorbid functioning, cognitive functioning, symptoms and outcome in schizophrenia. J. Psychiatry Neurosci. 1993;18:18–23
  2. Addington J, Addington D. Patterns of premorbid functioning in first episode psychosis: relationship to 2-year outcome. Acta Psychiatr. Scand. 2005;112:40–46
  3. Addington J, van Mastrigt S, Addington D. Patterns of premorbid functioning in first-episode psychosis: initial presentation. Schizophr. Res. 2003;62:23–30
  4. Allen DN, Frantom LV, Strauss GP, van Kammen DP. Differential patterns of premorbid academic and social deterioration in patients with schizophrenia. Schizophr. Res. 2005;75:389–397
  5. Amminger GP, Resch F, Mutschlechner R, Friedrich MH, Ernst E. Premorbid adjustment and remission of positive symptoms in first-episode psychosis. Eur. Child Adolesc. Psychiatry. 1997;6:212–218
  6. Asarnow JR, Ben-Meir S. Children with schizophrenia spectrum and depressive disorders: a comparative study of premorbid adjustment, onset pattern and severity of impairment. J. Child Psychol. Psychiatry. 1988;29:477–488
  7. Bailer J, Brauer W, Rey ER. Premorbid adjustment as predictor of outcome in schizophrenia: results of a prospective study. Acta Psychiatr. Scand. 1996;93:368–377
  8. Bartko G, Frecska E, Horvath S, Zador G, Arato M. Predicting neuroleptic response from a combination of multilevel variables in acute schizophrenic patients. Acta Psychiatr. Scand. 1990;82:408–412
  9. Bleuler E. Dementia praecox oder Gruppe der Schizophrenien. In:  Aschaffenburg Gustav editors. Handbuch der Psychiatrie. Leipzig und Wien; 1911;p. 1911–1928
  10. Bromet EJ, Jandorf L, Fennig S, Lavelle J, Kovasznay B, Ram R, et al. The Suffolk County Mental Health Project: demographic, pre-morbid and clinical correlates of 6-month outcome. Psychol. Med. 1996;26:953–962
  11. Cannon M, Jones P, Gilvarry C, Rifkin L, McKenzie K, Foerster A, et al. Premorbid social functioning in schizophrenia and bipolar disorder: similarities and differences. Am. J. Psychiatry. 1997;154:1544–1550
  12. Cannon M, Jones P, Huttunen MO, Tanskanen A, Huttunen T, Rabe-Hesketh S, et al. School performance in Finnish children and later development of schizophrenia: a population-based longitudinal study. Arch. Gen. Psychiatry. 1999;56:457–463
  13. Cannon-Spoor EH, Potkin SG, Wyatt RJ. Measurement of premorbid adjustment in chronic schizophrenia. Schizophr. Bull. 1982;8:470–484
  14. Casar C, Artamendi M, Gutierrez M, Gil P, Garcia MJ, Cuesta MJ. Neuropsychological deficits, obstetric complications and premorbid adjustment in patients with the first psychotic episode. Actas Luso-Esp. Neurol. Psiquiatr. Cienc. Afines. 1997;25:303–307
  15. Castle D, Sham P, Murray R. Differences in distribution of ages of onset in males and females with schizophrenia. Schizophr. Res. 1998;33:179–183
  16. Childers SE, Harding CM. Gender, premorbid social functioning and long-term outcome in DSM III schizophrenia. Schizophr. Bull. 1990;16:309–318
  17. Crespo-Facorro, B., Pelayo-Teran, J.M., Perez-Iglesias, R., Ramirez-Bonilla, M., Martinez-Garcia, O., Pardo-Garcia, G., Vazquez-Barquero, J.L., in press. Predictors of acute treatment response in patients with a first episode of non-affective psychosis: Sociodemographics, premorbid and clinical variables. J. Psychiatr. Res. doi:10.1016/j.jpsychires.2006.05.002.
  18. Davidson M, Reichenberg A, Rabinowitz J, Weiser M, Kaplan Z, Mark M. Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. Am. J. Psychiatry. 1999;156:1328–1335
  19. Deister A, Marneros A. Sex-dependent differences in endogenous psychoses. A comparison between schizophrenic, schizoaffective and affective psychoses. Fortschr. Neurol. Psychiatr. 1992;60:407–419
  20. DeLisi LE. The significance of age of onset for schizophrenia. Schizophr. Bull. 1992;18:209–215
  21. DeLisi LE, Schwartz CC, Targum SD, Byrnes SM, Spoor EC, Weinberger DR, et al. Ventricular brain enlargement and outcome of acute schizophreniform disorder. Psychiatry Res. 1983;9:169–171
  22. DeLisi LE, Goldin LR, Maxwell ME, Kazuba DM, Gerschon ES. Clinical features of illness in siblings with schizophrenia or schizoaffective disorder. Arch. Gen. Psychiatry. 1987;44:891–896
  23. DeQuardo JR, Tandon R, Goldman R, Meador-Woodruff JH, McGrath-Giroux M, Brunberg JA, et al. Ventricular enlargement, neuropsychological status, and premorbid function in schizophrenia. Biol. Psychiatry. 1994;35:517–524
  24. Dworkin RH. Patterns of sex differences in negative symptoms and social functioning consistent with separate dimensions of schizophrenic psychopathology. Am. J. Psychiatry. 1990;147:347–349
  25. Dworkin RH, Bernstein G, Kaplansky LM, Lipsitz JD, Rinaldi A, Slater SL, et al. Social competence and positive and negative symptoms: a longitudinal study of children and adolescents at risk for schizophrenia and affective disorder. Am. J. Psychiatry. 1991;148:1182–1188
  26. Edwards J, McGorry PD, Waddell FM, Harrigan SM. Enduring negative symptoms in first-episode psychosis: comparison of six methods using follow-up data. Schizophr. Res. 1999;40:147–158
  27. Erel O, Cannon TD, Hollister JM, Mednick SA, Parnas J. Ventricular enlargement and premorbid deficits in school-occupational attainment in a high risk sample. Schizophr. Res. 1991;4:49–52
  28. Falkai P, Schneider-Axmann T, Honer WG, Vogeley K, Schonell H, Pfeiffer U, et al. Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: a MRI study. Eur. Arch. Psychiatry Clin. Neurosci. 2003;253:92–99
  29. Fangerau H, Ohlraun S, Granath RO, Nothen MM, Rietschel M, Schulze TG. Computer-assisted phenotype characterisation for genetic research in psychiatry. Hum. Hered. 2004;58:122–130
  30. Fennig S, Putnam K, Bromet EJ, Galambos N. Gender, premorbid characteristics and negative symptoms in schizophrenia. Acta Psychiatr. Scand. 1995;92:173–177
  31. Fenton WS, McGlashan TH. Sustained remission in drug-free schizophrenic patients. Am. J. Psychiatry. 1987;144:1306–1309
  32. Fenton WS, McGlashan TH. Natural history of schizophrenia subtypes. I. Longitudinal study of paranoid, hebephrenic, and undifferentiated schizophrenia. Arch. Gen. Psychiatry. 1991;48:969–977
  33. First MB, Spitzer RL, Gibbon M, Williams J. Structured Clinical Interview for Axis I DSM-IV Disorders. New York: Biometrics Research; 1994;
  34. Fleischhaker C, Schulz E, Tepper K, Martin M, Hennighausen K, Remschmidt H. Long-term course of adolescent schizophrenia. Schizophr. Bull. 2005;31:769–780
  35. Foerster A, Lewis SW, Owen MJ, Murray RM. Low birth weight and a family history of schizophrenia predict poor premorbid functioning in psychosis. Schizophr. Res. 1991;5:13–20
  36. Garver DL, Nair TR, Christensen JD, Holcomb J, Ramberg J, Kingsbury S. Atrophic and static (neurodevelopmental) schizophrenic psychoses: premorbid functioning, symptoms and neuroleptic response. Neuropsychopharmacology. 1999;21:82–92
  37. Giron M, Gomez-Beneyto M. Relationship between empathic family attitude and relapse in schizophrenia: a 2-year follow up prospective study. Schizophr. Bull. 1998;24:619–627
  38. Gleeson JF, Rawlings D, Jackson HJ, McGorry PD. Agreeableness and neuroticism as predictors of relapse after first-episode psychosis: a prospective follow-up study. J. Nerv. Ment. Dis. 2005;193:160–169
  39. Goldstein MJ. Further data concerning the relationship between premorbid adjustment and paranoid symptomatology. Schizophr. Bull. 1978;4:236–243
  40. Gupta S, Rajaprabhakaran R, Arndt S, Flaum M, Andreasen NC. Premorbid adjustment as a predictor of phenomenological and neurobiological indices in schizophrenia. Schizophr. Res. 1995;16:189–197
  41. Gureje O, Aderibigbe YA, Olley O, Bamidele RW. Premorbid functioning in schizophrenia: a controlled study of Nigerian patients. Compr. Psychiatry. 1994;35:437–440
  42. Guy JD, Liaboe GP, Wallace CJ. Premorbid adjustment in adult male schizophrenics, as related to process vs. reactive, chronic vs. acute, age of onset, and neurologically impaired vs. non-impaired. J. Clin. Psychol. 1986;42:62–67
  43. Haas GL, Sweeney JA. Premorbid and onset features in of first episode schizophrenia. Schizophr. Bull. 1992;18:373–386
  44. Haefner H, Riecher-Rossler A, Hambrecht M, Maurer K, Meissner S, Schmidtke A, et al. IRAOS: an instrument for the assessment of onset and early course of schizophrenia. Schizophr. Res. 1992;6:209–223
  45. Haim R, Rabinowitz J, Bromet E. The relationship of premorbid functioning to illness course in schizophrenia and psychotic mood disorders during two years following first hospitalization. J. Nerv. Ment. Dis. 2006;194:791–795
  46. Hegerl U, Juckel G, Muller-Schubert A, Pietzcker A, Gaebel W. Schizophrenics with small P300: a subgroup with a neurodevelopmental disturbance and a high risk for tardive dyskinesia?. Acta Psychiatr. Scand. 1995;91:120–125
  47. Ho BC, Mola C, Andreasen NC. Cerebellar dysfunction in neuroleptic naive schizophrenia patients: clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs. Biol. Psychiatry. 2004;55:1146–1153
  48. Honer WG, Kopala LC, Rabinowitz J. Extrapyramidal symptoms and signs in first-episode, antipsychotic exposed and non-exposed patients with schizophrenia or related psychotic illness. J. Psychopharmacol. 2005;19:277–285
  49. Hubschmid T, Perrin N, Ciompi L. The dynamics of outcome predictors in the early phase of schizophrenic psychoses—an empirical study. Psychiatr. Prax. 1991;18:196–201
  50. Kay SR, Lindenmayer JP. Outcome predictors in acute schizophrenia. Prospective significance of background and clinical dimensions. J. Nerv. Ment. Dis. 1987;175:152–160
  51. Keefe RS, Mohs RC, Losonczy MF, Davidson M, Silverman JM, Horvath TB, et al. Premorbid sociosexual functioning and long-term outcome in schizophrenia. Am. J. Psychiatry. 1989;146:206–211
  52. Kelley ME, Gilbertson M, Mouton A, van Kammen DP. Deterioration in premorbid functioning in schizophrenia: a developmental model of negative symptoms in drug-free patients. Am. J. Psychiatry. 1992;149:1543–1548
  53. Klausner JD, Sweeney JA, Deck MD, Haas GL, Kelly AB. Clinical correlates of cerebral ventricular enlargement in schizophrenia. Further evidence for frontal lobe disease. J. Nerv. Ment. Dis. 1992;180:407–412
  54. Krauss H, Marwinski K, Held T, Rietschel M, Freyberger HJ. Reliability and validity of the premorbid adjustment scale (PAS) in a German sample of schizophrenia and schizoaffective patients. Eur. Arch. Psychiatry Clin. Neurosci. 1998;248:277–281
  55. Klorman R, Strauss JS, Kokes RF. Premorbid adjustment in schizophrenia. Part III. The relationship of demographic and diagnostic factors to measures of premorbid adjustment in schizophrenia. Schizophr. Bull. 1977;3:214–225
  56. Larsen TK, McGlashan TH, Johannessen JO, Vibe-Hansen L. First episode schizophrenia: II. Premorbid patterns by gender. Schizophr. Bull. 1996;22:257–269
  57. Leung A, Chue P. Sex differences in schizophrenia, a review of the literature. Acta Psychiatr. Scand. 2000;401:3–38
  58. Levitt JJ, Shenton ME, McCarley RW, Faux SF, Ludwig AS. Premorbid adjustment in schizophrenia: implications for psychosocial and ventricular pathology. Schizophr. Res. 1994;12:159–168
  59. Levitt JJ, O'Donnell BF, McCarley RW, Nestor PG, Shenton ME. Correlations of premorbid adjustment in schizophrenia with auditory event-related potential and neuropsychological abnormalities. Am. J. Psychiatry. 1996;153:1347–1349
  60. Lindstrom LH. Clinical and biological markers for outcome in schizophrenia: a review of a longitudinal follow-up study in Uppsala schizophrenia research project. Neuropsychopharmacology. 1996;14(3 Suppl.):23S–26S
  61. Malla AK, Norman RM, Takhar J, Manchanda R, Townsend L, Scholten D, et al. Can patients at risk for persistent negative symptoms be identified during their first episode of psychosis?. J. Nerv. Ment. Dis. 2004;192:455–463
  62. Malmberg A, Lewis G, David A, Allebeck P. Premorbid adjustment and personality in people with schizophrenia. Br. J. Psychiatry. 1998;172:308–313
  63. Marneros A, Deister A, Rohde A, Sakamoto K. Nonpsychopathological features of K. Schneider's mania. Jpn. J. Psychiatry Neurol. 1988;42:17–21
  64. Maurer K, Bentz C, Loffler W, Hafner H. Psychiatric handicap—precursor or social sequelae of schizophrenia?. Gesundheitswese. 1996;58(1 Suppl.):79–85
  65. McClellan J, McCurry C. Neurodevelopmental pathways in schizophrenia. Semin. Clin. Neuropsychiatry. 1998;3:320–332
  66. McClellan J, Breiger D, McCurry C, Hlastala SA. Premorbid functioning in early-onset psychotic disorders. J. Am. Acad. Child Adolesc. Psych. 2003;42:666–672
  67. McCreadie RG, Connolly MA, Williamson DJ, Athawes RW, Tilak-Singh D. The Nithsdale Schizophrenia Surveys. XII. 'Neurodevelopmental' Schizophrenia: a search for clinical correlates and putative aetiological factors. Br. J. Psychiatry. 1994;165:340–346
  68. McGlashan TH. The prediction of outcome in chronic schizophrenia. IV. The Chestnut Lodge follow-up study. Arch. Gen. Psychiatry. 1986;43:167–176
  69. McGlashan TH, Bardenstein KK. Gender differences in affective, schizoaffective and schizophrenic disorders. Schizophr. Bull. 1990;16:319–329
  70. McGuffin P, Farmer AE, Harvey I. A polydiagnostic application of the operational criteria in studies of psychotic illness. Arch. Gen. Psychiatry. 1991;48:764–770
  71. Mueser KT, Bellack AS, Morrison RL, Wixted JT. Social competence in schizophrenia: premorbid adjustment, social skill, and domains of functioning. J. Psychiatr. Res. 1990;24:51–63
  72. Mukherjee S, Mahadik SP, Schnur DB, Laev H, Reddy R. Abnormal growth of cultured skin fibroblasts associated with poor premorbid history in schizophrenic patients. Schizophr. Res. 1994;13:233–237
  73. Muratori F, Salvatori F, D'Arcangelo G, Viglione V, Picchi L. Childhood psychopathological antecedents in early onset schizophrenia. Eur. Psychiatr. 2005;20:309–314
  74. Norman RM, Malla AK, Manchanda R, Townsend L. Premorbid adjustment in first episode schizophrenia and schizoaffective disorders: a comparison of social and academic domains. Acta Psychiatr. Scand. 2005;112:30–39
  75. Peralta V, Cuesta MJ. Motor features in psychotic disorders. I Factor structure and clinical correlates. Schizophr. Res. 2001;47:107–116
  76. Peralta V, Cuesta MJ, de Leon J. Positive and negative symptoms/syndromes in schizophrenia: reliability and validity of different diagnostic systems. Psychol. Med. 1995;25:43–50
  77. Perez V, Catafau AM, Corripio I, Martin JC, Alvarez E. Preliminary evidence of striatal D2 receptor density as a possible biological marker of prognosis in naive schizophrenic patients. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 2003;27:767–770
  78. Picchioni MM, Toulopoulou T, Regojo A, Rijsdijk F, Landau S, Hall MH, et al. Premorbid development in twins with schizophrenia. Schizophr. Res. 2006;81(Suppl. 1):268
  79. Rabinowitz J, De Smedt G, Harvey PD, Davidson M. Relationship between premorbid functioning and symptom severity as assessed at first episode of psychosis. Am. J. Psychiatry. 2002;159:2021–2026
  80. Rabinowitz J, Harvey PD, Eerdekens M, Davidson M. Premorbid functioning and treatment response in recent-onset schizophrenia. Br. J. Psychiatry. 2006;189:31–35
  81. Reichenberg A, Rabinowitz J, Weiser M, Mark M, Kaplan Z, Davidson M. Premorbid functioning in a national population of male twins discordant for psychoses. Am. J. Psychiatry. 2000;157:1514–1516
  82. Rhinewine JP, Lencz T, Thaden EP, Cervellione KL, Burdick KE, Henderson I, et al. Neurocognitive profile in adolescents with early-onset schizophrenia: clinical correlates. Biol. Psychiatry. 2005;58:705–712
  83. Rifkin L, Lewis S, Jones P, Toone B, Murray R. Low birth weight and schizophrenia. Br. J. Psychiatry. 1994;165:357–362
  84. Robinson D, Woerner MG, Alvir JM, Bilder R, Goldman R, Geisler S, et al. Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch. Gen. Psychiatry. 1999;56:241–247
  85. Rund BR, Melle I, Friis S, Larsen TK, Midboe LJ, Opjordsmoen S, et al. Neurocognitive dysfunction in first-episode psychosis: correlates with symptoms, premorbid adjustment, and duration of untreated psychosis. Am. J. Psychiatry. 2004;161:466–472
  86. Sartorius N, Kaelber CT, Cooper JE, Roper MT, Rae DS, Gulbinat W, et al. Progress toward achieving a common language in psychiatry. Results from the field trial of the clinical guidelines accompanying the WHO classification of mental and behavioral disorders in ICD-10. Arch. Gen. Psychiatry. 1993;50:115–124
  87. Schulze TG, McMahon FJ. Defining the phenotype in human genetic studies: forward genetics and reverse phenotyping. Hum. Hered. 2004;58:131–138
  88. Shean GD. Syndromes of schizophrenia and language dysfunction. J. Clin. Psychol. 1999;55:233–240
  89. Siever LJ, van Kammen DP, Linnoila M, Alterman I, Hare T, Murphy DL. Smooth pursuit eye movement disorder and its psychobiologic correlates in unmedicated schizophrenics. Biol. Psychiatry. 1986;21:1167–1174
  90. Silverstein ML, Mavrolefteros G, Close D. Premorbid adjustment and neuropsychological performance in schizophrenia. Schizophr. Bull. 2002;28:157–165
  91. Silverstein ML, Mavrolefteros G, Turnbull A. Premorbid factors in relation to motor, memory, and executive functions deficits in adult schizophrenia. Schizophr. Res. 2003;61:271–280
  92. St Hilaire A, Holowka D, Cunningham H, Champagne F, Pukall M, King S. Explaining variation in the premorbid adjustment of schizophrenia patients: the role of season of birth and family history. Schizophr. Res. 2005;73:39–48
  93. Stephens JH, Richard P, McHugh PR. Suicide in patients hospitalized for schizophrenia: 1913–1940. J. Nerv. Ment. Dis. 1999;187:10–14
  94. Strous RD, Alvir JM, Robinson D, Gal G, Sheitman B, Chakos M, et al. Premorbid functioning in schizophrenia: relation to baseline symptoms, treatment response, and medication side effects. Schizophr. Bull. 2004;30:265–278
  95. Swanson CL, Gur RC, Bilker W, Petty RG, Gur RE. Premorbid educational attainment in schizophrenia: association with symptoms, functioning, and neurobehavioral measures. Biol. Psychiatry. 1998;44:739–747
  96. Tabares R, Sanjuan J, Gomez-Beneyto M, Leal C. Correlates of symptom dimensions in schizophrenia obtained with the Spanish version of the Manchester scale. Psychopathology. 2000;33:259–264
  97. Tamminga CA. Gender and schizophrenia. J. Clin. Psychiatry. 1997;15:33–37
  98. Torgalsboen AK. Full recovery from schizophrenia: the prognostic role of premorbid adjustment, symptoms at first admission, precipitating events and gender. Psychiatry Res. 1999;88:143–152
  99. Torrey EF, Miller J, Rawlings R, Yolken RH. Seasonality of births in schizophrenia and bipolar disorder: a review of the literature. Schizophr. Res. 1997;1–38
  100. Ucok A, Polat A, Genc A, Cakir S, Turan N. Duration of untreated psychosis may predict acute treatment response in first-episode schizophrenia. J. Psychiatr. Res. 2004;163–168
  101. Ucok A, Polat A, Cakir S, Genc A. One year outcome in first episode schizophrenia. Predictors of relapse. Eur. Arch. Psychiatry Clin. Neurosci. 2006;256:37–43
  102. van Kammen DP, Kelley ME, Gilbertson MW, Gurklis J, O'Connor DT. CSF dopamine beta-hydroxylase in schizophrenia: associations with premorbid functioning and brain computerized tomography scan measures. Am. J. Psychiatry. 1994;151:372–378
  103. van Mastrigt S, Addington J. Assessment of premorbid function in first-episode schizophrenia: modifications to the Premorbid Adjustment Scale. J. Psychiatry Neurosci. 2002;27:92–101
  104. Vazquez-Barquero JL, Cuesta Nunez MJ, Herrera Castanedo S, Diez Manrique JF, Pardo G, Dunn G. Sociodemographic and clinical variables as predictors of the diagnostic characteristics of first episodes of schizophrenia. Acta Psychiatr. Scand. 1996;94:149–155
  105. Vourdas A, Pipe R, Corrigall R, Frangou S. Increased developmental deviance and premorbid dysfunction in early onset schizophrenia. Schizophr. Res. 2003;62:13–22
  106. Walshe M, McDonald C, Grech A, Schulze K, Bramon E, Murray RM. Premorbid functioning in the unaffected siblings of patients with familial and non-familial schizophrenia. Schizophr. Res. 2006;81(Suppl. 1):272
  107. Weinberger DR, Cannon-Spoor E, Potkin SG, Wyatt RJ. Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. Am. J. Psychiatry. 1980;137:1410–1413
  108. Weiser M, Reichenberg A, Rabinowitz J, Kaplan Z, Mark M, Nahon D, et al. Gender differences in premorbid cognitive performance in a national cohort of schizophrenic patients. Schizophr. Res. 2000;45:185–190
  109. Werry JS, McClellan JM. Predicting outcome in child and adolescent (early onset) schizophrenia and bipolar disorder. J. Am. Acad. Child Adolesc. Psych. 1992;31:147–150
  110. Werry JS, McClellan JM, Chard L. Childhood and adolescent schizophrenic, bipolar, and schizoaffective disorders: a clinical and outcome study. J. Am. Acad. Child Adolesc. Psych. 1991;30:457–465
  111. Wickham H, Walsh C, Asherson P, Gill M, Owen MJ, McGuffin P, et al. Familiality of clinical characteristics in schizophrenia. Schizophr. Res. 2002;36:325–329
  112. Wieselgren IM, Lindstrom LH. A prospective 1–5 year outcome study in first-admitted and readmitted schizophrenic patients: relationship to heredity, premorbid adjustment, duration of disease and education level at index admission and neuroleptic treatment. Acta Psychiatr. Scand. 1996;93:9–19
  113. Willinger U, Heiden AM, Meszaros K, Formann AK, Aschauer HN. Neurodevelopmental schizophrenia: obstetric complications, birth weight, premorbid social withdrawal and learning disabilities. Neuropsychobiology. 2001;43:163–169

PII: S0920-9964(07)00076-X

doi: 10.1016/j.schres.2007.01.016

Schizophrenia Research
Volume 92, Issue 1 , Pages 50-62 , May 2007

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