Schizophrenia Research
Volume 91, Issue 1 , Pages 103-106 , March 2007

Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia

  • Paul G. Nestor

      Affiliations

    • Department of Psychology, University of Massachusetts, Boston, United States
    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • Corresponding Author InformationCorresponding author. Department of Psychology, University of Massachusetts-Boston, Boston, MA 02125-3393, United States. Tel.: +1 617 287 6387.
    • ,
  • Toshiaki Onitsuka

      Affiliations

    • Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Ronald J. Gurrera

      Affiliations

    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Margaret Niznikiewicz

      Affiliations

    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Melissa Frumin

      Affiliations

    • Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Martha E. Shenton

      Affiliations

    • Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Robert W. McCarley

      Affiliations

    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States

Received 13 September 2006 ,Revised 14 November 2006 ,Accepted 17 November 2006.

References 

  1. Barta PE, Pearlson GD, Powers RE, Richards SS, Lune LE. Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am. J. Psychiatry. 1990;147:1457–1462
  2. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders — Clinician Version. Washington, DC: American Psychiatric Press; 1997;
  3. Gaser C, Nenadic I, Volz HP, Buchel C, Sauer H. Neuroanatomy of ‘hearing voices’: a frontotemporal brain structural abnormality associated with auditory hallucinations in schizophrenia. Cereb. Cortex. 2004;14:91–96
  4. Kay SR, Opler LA, Fiszbein A. Positive and Negative Syndrome Scale (PANSS). New York, NY: Multi-Health Systems, Inc.; 1986;
  5. McCarley RW, Shenton ME, O'Donnell BF, Faux SF, Kikinis R, Nestor PG, et al. Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia. Arch. Gen. Psychiatry. 1993;50:190–197
  6. McLellan AT, Kushner H, Metzger D, Peters R, Smith I, Grissom G, et al. The fifth edition of the addiction severity index. J. Subst. Abuse Treat. 1992;9:199–213
  7. Nestor PG, Shenton ME, McCarley RW, Haimson J, Smith RS, O'Donnell B, et al. Neuropsychological correlates of MRI temporal lobe abnormalities in schizophrenia. Am. J. Psychiatry. 1993;150:1849–1855
  8. Onitsuka T, Shenton ME, Kasai K, Nestor PG, Toner SK, Kikinis R, et al. Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia. Arch. Gen. Psychiatry. 2003;60:349–355
  9. Onitsuka T, Shenton ME, Salisbury DF, Dickey CC, Kasai K, Toner SK, et al. Middle and inferior temporal gyrus gray matter volume abnormalities in schizophrenia: an MRI study. Am. J. Psychiatry. 2004;161:1603–1611
  10. Onitsuka T, Nestor PG, Gurrera RJ, Shenton ME, Kasai K, Frumin M, et al. Association between reduced extraversion and right posterior fusiform gyrus gray matter reduction in chronic schizophrenia. Am. J. Psychiatry. 2005;162:599–601
  11. Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia: a quantitative MRI study. N. Engl. J. Med. 1992;327:604–612

☆ This work was supported by the National Institute of Health (K02 MH 01110 and R01 MH 50747 to MES, R01 MH 40799 to RWM, RO1 MH 63360 to MN), the Department of Veterans Affairs Merit Awards (MES, MN, PGN, RWM), the Department of Veterans Affairs REAP Award (RWM), the MIND Institute (Albuquerque, NM) and a VA Psychiatry/Neuroscience Research Fellowship Award (MF).

PII: S0920-9964(06)00485-3

doi: 10.1016/j.schres.2006.11.025

Schizophrenia Research
Volume 91, Issue 1 , Pages 103-106 , March 2007

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