Schizophrenia Research
Volume 91, Issue 1 , Pages 103-106, March 2007

Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia☆

  • Paul G. Nestor

      Affiliations

    • Department of Psychology, University of Massachusetts, Boston, United States
    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • Corresponding Author InformationCorresponding author. Department of Psychology, University of Massachusetts-Boston, Boston, MA 02125-3393, United States. Tel.: +1 617 287 6387.
    • ,
  • Toshiaki Onitsuka

      Affiliations

    • Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Ronald J. Gurrera

      Affiliations

    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Margaret Niznikiewicz

      Affiliations

    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Melissa Frumin

      Affiliations

    • Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Martha E. Shenton

      Affiliations

    • Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Robert W. McCarley

      Affiliations

    • Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, United States

Received 13 September 2006; received in revised form 14 November 2006; accepted 17 November 2006. published online 18 January 2007.

Abstract 

We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning were examined within the same subjects. The results indicated two distinct, dissociable brain structure-function relationships: (1) reduced left STG volume-positive symptoms-executive deficits; (2) reduced left FG-negative symptoms-facial memory deficits. STG and FG volume reductions may each make distinct contributions to symptoms and cognitive deficits of schizophrenia.

Keywords: Schizophrenia, MRI, Neuropsychology, Symptoms

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☆ This work was supported by the National Institute of Health (K02 MH 01110 and R01 MH 50747 to MES, R01 MH 40799 to RWM, RO1 MH 63360 to MN), the Department of Veterans Affairs Merit Awards (MES, MN, PGN, RWM), the Department of Veterans Affairs REAP Award (RWM), the MIND Institute (Albuquerque, NM) and a VA Psychiatry/Neuroscience Research Fellowship Award (MF).

PII: S0920-9964(06)00485-3

doi:10.1016/j.schres.2006.11.025

Schizophrenia Research
Volume 91, Issue 1 , Pages 103-106, March 2007

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