Schizophrenia Research
Volume 90, Issue 1 , Pages 71-75, February 2007

Reduction of right medial pulvinar volume and neuron number in schizophrenia

  • William Byne

      Affiliations

    • Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    • Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, United States
    • Corresponding Author InformationCorresponding author. Research Bldg. Rm 2F37, Bronx Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, United States. Tel.: +1 718 584 9000x6041; fax: +1 718 562 9120.
    • ,
  • Jason Fernandes

      Affiliations

    • Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    • ,
  • Vhram Haroutunian

      Affiliations

    • Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    • Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, United States
    • ,
  • Dennis Huacon

      Affiliations

    • Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    • ,
  • Smith Kidkardnee

      Affiliations

    • Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    • ,
  • John Kim

      Affiliations

    • Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    • ,
  • Alex Tatusov

      Affiliations

    • Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    • Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, United States
    • ,
  • Uma Thakur

      Affiliations

    • Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    • ,
  • Georgia Yiannoulos

      Affiliations

    • Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States

Received 23 June 2006; received in revised form 3 October 2006; accepted 16 October 2006. published online 06 December 2006.

Abstract 

Several studies have described a reduction of pulvinar volume and/or neuronal number in schizophrenia (SZ). In order to better localize these changes, we assessed volume and neuronal number of the pulvinar and several of its subdivisions in postmortem material from subjects with chronic SZ and subjects with no psychiatric history. Total pulvinar volume and neuronal number were significantly lower in SZ and these differences were significant in only in its medial division. The medial pulvinar interconnects various heteromodal cortical regions suggesting that these deficits may contribute to the abnormalities of higher order integrative functions characteristic of schizophrenia.

Keywords: Schizophrenia, Thalamus, Pulvinar, Postmortem

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0920-9964(06)00448-8

doi:10.1016/j.schres.2006.10.006

Schizophrenia Research
Volume 90, Issue 1 , Pages 71-75, February 2007

Article Tools

* Image Usage & Resolution