Schizophrenia Research
Volume 89, Issue 1 , Pages 72-85 , January 2007

Minor physical anomalies in schizophrenia: A meta-analysis

  • Seth M. Weinberg

      Affiliations

    • Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    • Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    • Corresponding Author InformationCorresponding author. 100 Technology Drive, Suite 500, Pittsburgh, PA 15219, USA. Tel.: +1 412 648 9206; fax: +1 412 648 8779.
    • ,
  • Elizabeth A. Jenkins

      Affiliations

    • Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    • ,
  • Mary L. Marazita

      Affiliations

    • Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    • Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    • Department of Oral and Maxillofacial Surgery, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    • Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    • ,
  • Brion S. Maher

      Affiliations

    • Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA

Received 9 June 2006 ,Revised 30 August 2006 ,Accepted 6 September 2006.

References 

  1. Akabaliev VH, Sivkov ST. Minor physical anomalies in schizophrenia. Folia Med. (Plovdiv). 1998;40(2):39–45
  2. Akabaliev VH, Sivkov ST. Sexual dimorphism in minor physical anomalies in schizophrenic patients and normal controls. Compr. Psychiatry. 2003;44(4):341–348
  3. Akabaliev VH, Sivkov ST, Baltadjiev GA. Discriminant analysis of minor physical anomalies as dysontogenetic markers of schizophrenia. Folia Med. (Plovdiv). 2001;43(3):21–26
  4. Alexander RC, Mukherjee S, Richter J, Kaufmann CA. Minor physical anomalies in schizophrenia. J. Nerv. Ment. Dis. 1994;182(11):639–644
  5. Buckley PF. The clinical stigmata of aberrant neurodevelopment in schizophrenia. J. Nerv. Ment. Dis. 1998;186(2):79–86
  6. Buckley PF, Moore C, Long H, Larkin C, Thomson P, Mulvany F, et al. 1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates. Biol. Psychiatry. 1994;36(12):792–800
  7. Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: historical and meta-analytic review. Am. J. Psychiatry. 2002;159(7):1080–1092
  8. Cannon M, Dean K, Jones PB. Early environmental risk factors for schizophrenia. In:  Keshavan MS,  Kennedy JL,  Murray RM editor. Neurodevelopment and Schizophrenia. Cambridge: Cambridge University Press; 2004;p. 191–209
  9. Cantor-Graae E, McNeil TF, Torrey EF, Quinn P, Bowler A, Sjostrom K, et al. Link between pregnancy complications and minor physical anomalies in monozygotic twins discordant for schizophrenia. Am. J. Psychiatry. 1994;151(8):1188–1193
  10. Cantor-Graae E, Ismail B, McNeil TF. Neonatal head circumference and related indices of disturbed fetal development in schizophrenic patients. Schizophr. Res. 1998;32(3):191–199
  11. Cochran WG. The combination of estimates from different experiments. Biometrics. 1954;10(1):101–129
  12. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Hillsdale: Lawrence Earlbaum Associates; 1988;
  13. Davies N, Russell A, Jones P, Murray RM. Which characteristics of schizophrenia predate psychosis?. J. Psychiatr. Res. 1998;32(3–4):121–131
  14. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control. Clin. Trials. 1986;7(3):177–188
  15. Edgar JC, Yeo RA, Gangestad SW, Blake MB, Davis JT, Lewine JD, et al. Reduced auditory M100 asymmetry in schizophrenia and dyslexia: applying a developmental instability approach to assess atypical brain asymmetry. Neuropsychologia. 2005;44(2):289–299
  16. Elizarraras-Rivas J, Fragoso-Herrera R, Cerdan-Sanchez LF, Ramos-Zepeda R, Barajas-Barajas LO, Troyo-Sanroman R. Minor physical anomalies and anthropometric measures in schizophrenia: a pilot study from Mexico. Schizophr. Res. 2003;62(3):285–287
  17. Francis-West PH, Robson L, Evans DJ. Craniofacial development: the tissue and molecular interactions that control development of the head. Adv. Anat. Embryol. Cell Biol. 2003;169:1–138
  18. Geddes JR, Lawrie SM. Obstetric events in schizophrenia: a meta-analysis. Br. J. Psychiatry. 1995;167(6):786–793
  19. Gourion D, Goldberger C, Bourdel MC, Bayle FJ, Millet B, Olie JP, et al. Neurological soft-signs and minor physical anomalies in schizophrenia: differential transmission within families. Schizophr. Res. 2003;63(1–2):181–187
  20. Gourion D, Goldberger C, Bourdel MC, Bayle FJ, Loo H, Krebs MO. Minor physical anomalies in patients with schizophrenia and their parents: prevalence and pattern of craniofacial abnormalities. Psychiatry Res. 2004;125(1):21–28
  21. Gourion D, Goldberger C, Olie JP, Loo H, Krebs MO. Neurological and morphological anomalies and the genetic liability to schizophrenia: a composite phenotype. Schizophr. Res. 2004;67(1):23–31
  22. Green MF, Satz P, Soper HV, Kharabi F. Relationship between physical anomalies and age at onset of schizophrenia. Am. J. Psychiatry. 1987;144(5):666–667
  23. Green MF, Satz P, Gaier DJ, Ganzell S, Kharabi F. Minor physical anomalies in schizophrenia. Schizophr. Bull. 1989;15(1):91–99
  24. Green MF, Satz P, Christenson CD. Minor physical anomalies in schizophrenia patients, bipolar patients, and their siblings. Schizophr. Bull. 1994;20(3):433–440
  25. Green MF, Bracha HS, Satz P, Christenson CD. Preliminary evidence for an association between minor physical anomalies and second trimester neurodevelopment in schizophrenia. Psychiatry Res. 1994;53(2):119–127
  26. Griffiths TD, Sigmundsson T, Takei N, Frangou S, Birkett PB, Sharma T, et al. Minor physical anomalies in familial and sporadic schizophrenia: the Maudsley family study. J. Neurol. Neurosurg. Psychiatry. 1998;64(1):56–60
  27. Gualtieri CT, Adams A, Shen CD, Loiselle D. Minor physical anomalies in alcoholic and schizophrenic adults and hyperactive and autistic children. Am. J. Psychiatry. 1982;139(5):640–643
  28. Guy JD, Majorski LV, Wallace CJ, Guy MP. The incidence of minor physical anomalies in adult male schizophrenics. Schizophr. Bull. 1983;9(4):571–582
  29. Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain. 1999;122(4):593–624
  30. Hata K, Iida J, Iwasaka H, Negoro HI, Ueda F, Kishimoto T. Minor physical anomalies in childhood and adolescent onset schizophrenia. Psychiatry Clin. Neurosci. 2003;57(1):17–21
  31. Hata K, Iida J, Iwasaka H, Negoro H, Kishimoto T. Association between minor physical anomalies and leteral ventricular enlargement in childhood and adolescent onset schizophrenia. Acta Psychiatr. Scand. 2003;108(2):147–151
  32. Hedges LV, Olkin I. Statistical Methods for Meta-Analysis. Orlando: Academic Press, Inc.; 1985;
  33. Hennessy RJ, Lane A, Kinsella A, Larkin C, O'Callaghan E, Waddington JL. 3D morphometrics of craniofacial dysmorphology reveals sex-specific asymmetries in schizophrenia. Schizophr. Res. 2004;67(2–3):261–268
  34. Hoyme HE. Minor anomalies: diagnostic clues to aberrant human morphogenesis. Genetica. 1993;89(1–3):307–315
  35. Ismail B, Cantor-Graae E, McNeil TF. Minor physical anomalies in schizophrenic patients and their siblings. Am. J. Psychiatry. 1998;155(12):1695–1702
  36. Ismail B, Cantor-Graae E, McNeil TF. Minor physical anomalies in schizophrenia: cogitive, neurological and other clinical correlates. J. Psychiatr. Res. 2000;34(1):45–56
  37. Jones KL. Smith's Recognizable Patterns of Human Malformation. Philadelphia: W.B. Saunders Company; 1997;
  38. Joo EJ, Jeong SH, Ahn YN, Lee KY, Yoon SC, Kim EJ, et al. No association found between 158 Val/Met polymorphism of the COMT gene and schizophrenia with minor physical anomalies. Psychiatry Res. 2005;136(2–3):83–91
  39. Kelly BD, Lane A, Agartz I, Henriksson KM, McNeil TF. Craniofacial dysmorphology in Swedish schizophrenia patients. Acta Psychiatr. Scand. 2005;111(3):202–207
  40. Kline RB. Beyond Significance Testing: Reforming Data Analysis Methods in Behavioral Research. Washington, DC: American Psychological Association; 2004;
  41. Kravariti E, Dazzan P, Fearon P, Murray RM. Can one identify preschizophrenic children?. In:  Keshavan MS,  Kennedy JL,  Murray RM editor. Neurodevelopment and Schizophrenia. Cambridge: Cambridge University Press; 2004;p. 415–431
  42. Krause JP, Kauffman JM. Minor physical anomalies in exceptional children: a review and critique of research. J. Abnorm. Child Psychol. 1982;10(2):247–264
  43. Lal R, Sharma S. Minor physical anomalies in schizophrenia. Indian J. Psychiatry. 1987;29(2):119–122
  44. Lane A, Kinsella A, Murphy P, Byrne M, Keenan J, Colgan K, et al. The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins. Psychol. Med. 1997;27(5):1155–1164
  45. Lawrie SM, Byrne M, Miller P, Hodges A, Clafferty R, Owens DC, et al. Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia. Br. J. Psychiatry. 2001;178(6):524–530
  46. Le Douarin NM, Kalcheim C. The Neural Crest. Cambridge: Cambridge University Press; 1999;
  47. Lloyd T, Doody G, Brewin J, Park B, Jones P. Minor physical anomalies in schizophrenia: is age a confounding factor?. Schizophr. Res. 2003;61(1):67–73
  48. Lohr JB, Flynn K. Minor physical anomalies in schizophrenia and mood disorders. Schizophr. Bull. 1993;19(3):551–556
  49. Lohr JB, Alder M, Flynn K, Harris MJ, McAdams LA. Minor physical anomalies in older patients with late-onset schizophrenia, early-onset schizophrenia, depression, and Alzheimer's disease. Am. J. Geriatr. Psychiatry. 1997;5(4):318–323
  50. Marcus J, Hans SL, Byhouwer B, Norem J. Relationships among neurological functioning, intelligence quotients, and physical anomalies. Schizophr. Bull. 1985;11(1):101–106
  51. Marenco S, Weinberger DR. The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from the cradle to grave. Dev. Psychopathol. 2000;12(3):501–527
  52. McGrath JJ, van Os J, Jones PB, Harvey I, Murray RM. Minor physical anomalies in psychosis: associations with clinical and putative aetiological variables. Schizophr. Res. 1995;18(1):9–20
  53. McGrath JJ, El-Saadi O, Grim V, Cardy S, Chapple B, Chant D, et al. Minor physical anomalies and quantitative measures of the head and face in patients with psychosis. Arch. Gen. Psychiatry. 2002;59(5):458–464
  54. McGrath JJ, Feron FP, Burne THJ, Mackay-Sim A, Eyles DW. The neurodevelopmental hypothesis of schizophrenia: a review of recent developments. Ann. Med. 2003;35(2):86–93
  55. McNeil TF, Cantor-Graae E. Does preexisting abnormality cause labor-delivery complications in fetuses who will develop schizophrenia?. Schizophr. Bull. 1999;25(3):425–435
  56. McNeil TF, Cantor-Graae E. Minor physical anomalies and obstetric complications in schizophrenia. Aust. N. Z. J. Psychiatry. 2000;34:S65–S73(Suppl)
  57. McNeil TF, Blennow G, Lundberg L. Congenital malformations and structural developmental anomalies in groups at high risk for psychosis. Am. J. Psychiatry. 1992;149(1):57–61
  58. McNeil TF, Cantor-Graae E, Ismail B. Obstetric complications and congenital malformation in schizophrenia. Brain Res. Brain Res. Rev. 2000;31(2–3):166–178
  59. Murphy K, Owen MJ. Minor physical anomalies and their relationship to the aetiology of schizophrenia. Br. J. Psychiatry. 1996;168(2):139–142
  60. Murray RM, O'Callaghan E, Castle DJ, Lewis SW. A neurodevelopmental approach to the classification of schizophrenia. Schizophr. Bull. 1992;18(2):319–332
  61. Nizamie SH, Nizamie A, Sangma MW, Sharma PL. Soft neurological signs and minor physical anomalies in schizophrenia. Indian J. Psychiatry. 1989;31(3):230–237
  62. O'Callaghan E, Larkin C, Kinsella A, Waddington JL. Familial, obstetric, and other clinical correlates of minor physical anomalies in schizophrenia. Am. J. Psychiatry. 1991;148(4):479–483
  63. O'Callaghan E, Buckley P, Madigan C, Redmond O, Stack JP, Kinsella A, et al. The relationship of minor physical anomalies and other putative indices of developmental disturbance in schizophrenia to abnormalities of cerebral structure on magnetic resonance imaging. Biol. Psychiatry. 1995;38(8):516–524
  64. Ponnudurai R. A study of some somatic traits in schizophrenia. Indian J. Psychiatry. 1986;28(3):249–251
  65. Puri BK, El-Dosoky A, Cheema S, Lekh SK, Hall AD, Mortimer AM. Parietal scalp hair whorl patterns in schizophrenia. Biol. Psychiatry. 1995;37(4):278–279
  66. Roberts GW, Colter N, Lofthouse R, Johnstone EC, Crow TJ. Is there gliosis in schizophrenia? Investigation of the temporal lobe. Biol. Psychiatry. 1987;22(12):1459–1468
  67. Rosenthal R. The ‘file drawer’ problem and tolerance for null results. Psychol. Bull. 1979;86(3):638–641
  68. Schiffman J, Ekstrom M, LaBrie J, Schulsinger F, Sorenson H, Mednick S. Minor physical anomalies and schizophrenia spectrum disorders: a prospective investigation. Am. J. Psychiatry. 2002;159(2):238–243
  69. Scutt LE, Chow EWC, Weksberg R, Honer WG, Bassett AS. Patterns of dysmorphic features in schizophrenia. Am. J. Med. Genet. 2001;105(8):713–723
  70. Sivkov ST, Akabaliev VH. Minor physical anomalies in schizophrenic patients and normal controls. Psychiatry. 2003;66(3):222–233
  71. Sivkov ST, Akabaliev VH. Discriminating value of total minor anomaly score on the Waldrop physical anomaly scale between schizophrenia patients and normal control subjects. Schizophr. Bull. 2004;30(2):361–366
  72. Sutton AJ, Abrams KR, Jones DR, Sheldon TA, Song F. Methods for Meta-Analysis in Medical Research. Chichester: John Wiley and Sons, Ltd.; 2000;
  73. Tarrant CJ, Jones PB. Precursors to schizophrenia: do biological markers have specificity. Can. J. Psychiatry. 1999;44(4):335–349
  74. Thompson SG, Sharp SJ. Explaining heterogeneity in meta-analysis: a comparison of methods. Stat. Med. 1999;18(20):2693–2708
  75. Trixler M, Tényi T, Csábi G, Szabó G, Méhes K. Informative morphogenetic variants in patients with schizophrenia and alcohol-dependant patients: beyond the Waldrop scale. Am. J. Psychiatry. 1997;154(5):691–693
  76. Trixler M, Tényi T, Csábi G, Szabó R. Minor physical anomalies in schizophrenia and bipolar affective disorder. Schizophr. Res. 2001;52(3):195–201
  77. Waddington JL, O'Callaghan E, Buckley P, Madigan C, Redmond O, Stack JP, et al. Tardive dyskinesia in schizophrenia relationship to minor physical anomalies, frontal lobe dysfunction and cerebral structure on magnetic resonance imaging. Br. J. Psychiatry. 1995;167(1):41–44
  78. Waddington JL, Lane A, Scully P, Meagher D, Quinn J, Larkin C, et al. Early cerebro-craniofacial dysmorphogenesis in schizophrenia: a lifetime trajectory model from neurodevelopmental basis to ‘neuroprogressive’ process. J. Psychiatr. Res. 1999;33(6):477–489
  79. Waldrop MF, Halverson CF. Minor physical anomalies and hyperactive behavior in children. In:  Hellmuth J editors. Exceptional Infant: Studies in Abnormalities. New York: Brunner/Mazel; 1971;p. 343–380
  80. Waldrop MF, Pedersen FA, Bell RQ. Minor physical anomalies and behavior in preschool children. Child Dev. 1968;39(2):391–400
  81. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry. 1987;44(7):660–669
  82. Weinstein DD, Diforio D, Schiffman J, Walker E, Bonsall R. Minor physical anomalies, dermatoglyphic asymmetries, and cortisol levels in adolescents with schizotypal personality disorder. Am. J. Psychiatry. 1999;156(4):617–623
  83. Woods BT. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am. J. Psychiatry. 1998;155(12):1661–1670

PII: S0920-9964(06)00398-7

doi: 10.1016/j.schres.2006.09.002

Schizophrenia Research
Volume 89, Issue 1 , Pages 72-85 , January 2007

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