Schizophrenia Research
Volume 89, Issue 1 , Pages 312-319 , January 2007

Genetic and environmental influences on sensory gating of mid-latency auditory evoked responses: A twin study

  • Andrey P. Anokhin

      Affiliations

    • Department of Psychiatry, Washington University School of Medicine, St.Louis, MO, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 314 286 2201; fax: +1 314 286 0092.
  • ,
  • Andrei B. Vedeniapin

      Affiliations

    • Department of Psychiatry, Washington University School of Medicine, St.Louis, MO, USA
  • ,
  • Andrew C. Heath

      Affiliations

    • Department of Psychiatry, Washington University School of Medicine, St.Louis, MO, USA
  • ,
  • Oleg Korzyukov

      Affiliations

    • Wayne State University School of Medicine, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI, USA
  • ,
  • Nashaat N. Boutros

      Affiliations

    • Wayne State University School of Medicine, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI, USA

Received 22 March 2006 ,Revised 20 July 2006 ,Accepted 14 August 2006.

References 

  1. Adler LE, Freedman R, Ross RG, A.Waldo MC. Elementary phenotypes in the neurobiological and genetic study of schizophrenia. Biol. Psychiatry. 1999;46(1):8–18
  2. Arnfred SM, Chen AC, Glenthoj BY, Hemmingsen RP. Normal p50 gating in unmedicated schizophrenia outpatients. Am. J. Psychiatry. 2003;160(12):2236–2238
  3. Blumenfeld LD, Clementz BA. Response to the first stimulus determines reduced auditory evoked response suppression in schizophrenia: single trials analysis using MEG. Clin. Neurophysiol. 2001;112(9):1650–1659
  4. Boutros NN, Belger A. Midlatency evoked potentials attenuation and augmentation reflect different aspects of sensory gating. Biol. Psychiatry. 1999;45(7):917–922
  5. Boutros NN, Overall J, Zouridakis G. Test–retest reliability of the P50 mid-latency auditory evoked response. Psychiatry Res. 1991;39(2):181–192
  6. Boutros NN, Belger A, Campbell D, D'Souza C, Krystal J. Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report. Psychiatry Res. 1999;88(2):119–130
  7. Boutros NN, Korzyuko O, Oliwa G, Feingold A, Campbell D, McClain-Furmanski D, et al. Morphological and latency abnormalities of the mid-latency auditory evoked responses in schizophrenia: a preliminary report. Schizophr. Res. 2004;70(2–3):303–313
  8. Boutros NN, Korzyukov O, Jansen B, Feingold A, Bell M. Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients. Psychiatry Res. 2004;126(3):203–215
  9. Braff DL, Geyer MA. Sensorimotor gating and schizophrenia. Human and animal model studies. Arch. Gen. Psychiatry. 1990;47(2):181–188
  10. Braff DL, Light GA. Preattentional and attentional cognitive deficits as targets for treating schizophrenia. Psychopharmacology (Berl). 2004;174(1):75–85
  11. Bramon E, Rabe-Hesketh S, Sham P, Murray RM, Frangou S. Meta-analysis of the P300 and P50 waveforms in schizophrenia. Schizophr. Res. 2004;70(2–3):315–329
  12. Buchsbaum MS. The middle evoked response components and schizophrenia. Schizophr. Bull. 1977;3(1):93–104
  13. Cadenhead KS, Light GA, Geyer MA, Braff DL. Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder. Am. J. Psychiatry. 2000;157(1):55–59
  14. Cardenas VA, Gerson J, Fein G. The reliability of P50 suppression as measured by the conditioning/testing ratio is vastly improved by dipole modeling. Biol. Psychiatry. 1993;33(5):335–344
  15. Clementz BA, Blumenfeld LD. Multichannel electroencephalographic assessment of auditory evoked response suppression in schizophrenia. Exp. Brain Res. 2001;139(4):377–390
  16. Clementz BA, Geyer MA, Braff DL. P50 suppression among schizophrenia and normal comparison subjects: a methodological analysis. Biol. Psychiatry. 1997;41(10):1035–1044
  17. Croft RJ, Lee A, Bertolot J, Gruzelier JH. Associations of P50 suppression and desensitization with perceptual and cognitive features of “unreality” in schizotypy. Biol. Psychiatry. 2001;50(6):441–446
  18. Curtis L, Blouin JL, Radhakrishna U, Gehrig C, Lasseter VK, Wolyniec P, et al. No evidence for linkage between schizophrenia and markers at chromosome 15q13-14. Am. J. Med. Genet. 1999;88(2):109–112
  19. Davis H, Mast T, Yoshie N, Zerlin S. The slow response of the human cortex to auditory stimuli: recovery process. Electroencephalogr. Clin. Neurophysiol. 1966;21(2):105–113
  20. Fein G, Biggins C, MacKay S. Cocaine abusers have reduced auditory P50 amplitude and suppression compared to both normal controls and alcoholics. Biol. Psychiatry. 1996;39(11):955–965
  21. Freedman R, Adler LE, Waldo MC, Pachtman E, Franks RD. Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients. Biol. Psychiatry. 1983;18(5):537–551
  22. Freedman R, Adams CE, Adler LE, Bickford PC, Gault J, Harris JG, et al. Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia. Am. J. Med. Genet. 2000;97(1):58–64
  23. Freedman R, Olincy A, Ross RG, Waldo MC, Stevens KE, Adler LE, et al. The genetics of sensory gating deficits in schizophrenia. Curr. Psychiatry Rep. 2003;5(2):155–161
  24. Grunwald T, Boutros NN, Pezer N, von Oertzen J, Fernandez G, Schaller C, et al. Neuronal substrates of sensory gating within the human brain. Biol. Psychiatry. 2003;53(6):511–519
  25. Hetrick WP, Sandman CA, Bunney WE, Jin Y, Potkin SG, White MH. Gender differences in gating of the auditory evoked potential in normal subjects. Biol. Psychiatry. 1996;39(1):51–58
  26. Jin Y, Bunney WE, Sandman CA, Patterson JV, Fleming K, Moenter JR, et al. Is P50 suppression a measure of sensory gating in schizophrenia?. Biol. Psychiatry. 1998;43(12):873–878
  27. Johannesen JK, Kieffaber PD, O'Donnell BF, Shekhar A, Evans JD, Hetrick WP. Contributions of subtype and spectral frequency analyses to the study of P50 ERP amplitude and suppression in schizophrenia. Schizophr. Res. 2005;78(2–3):269–284
  28. Kisley MA, Noecker TL, Guinther PM. Comparison of sensory gating to mismatch negativity and self-reported perceptual phenomena in healthy adults. Psychophysiology. 2004;41(4):604–612
  29. Li CH, Liao HM, Chen CH. Identification of molecular variants at the promoter region of the human alpha 7 neuronal nicotinic acetylcholine receptor subunit gene but lack of association with schizophrenia. Neurosci. Lett. 2004;372(1–2):1–5
  30. Marco J, Fuentemilla L, Grau C. Auditory sensory gating deficit in abstinent chronic alcoholics. Neurosci. Lett. 2005;375(3):174–177
  31. Myles-Worsley M, Coon H, Byerley W, Waldo M, Young D, Freedman R. Developmental and genetic influences on the P50 sensory gating phenotype. Biol. Psychiatry. 1996;39(4):289–295
  32. Nagamoto HT, Adler LE, Waldo MC, Freedman R. Sensory gating in schizophrenics and normal controls: effects of changing stimulation interval. Biol. Psychiatry. 1989;25(5):549–561
  33. Neale MC, Cardon LR. Methodology for Genetic Studies of Twins and Families. Dordrecht: Kluwer Academic Publishers; 1992;
  34. Neves-Pereira M, Bassett AS, Honer WG, Lang D, King NA, Kennedy JL. No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families. Am. J. Med. Genet. 1998;81(5):361–363
  35. Patrick G, Struve FA. Reduction of auditory P50 gating response in marihuana users: further supporting data. Clin. Electroencephalogr. 2000;31(2):88–93
  36. Rijsdijk FV, Sham PC. Analytic approaches to twin data using structural equation models. Brief. Bioinform. 2002;3(2):119–133
  37. Roth WT, Horvath TB, Pfefferbaum A, Kopell BS. Event-related potentials in schizophrenics. Electroencephalogr. Clin. Neurophysiol. 1980;48(2):127–139
  38. Smith DA, Boutros NN, Schwarzkopf SB. Reliability of P50 auditory event-related potential indices of sensory gating. Psychophysiology. 1994;31(5):495–502
  39. Venables P. Input dysfunction in schizophrenia. In:  Maher BA editors. Progress in Experimental Personality Research. New York: Academic Press; 1964;p. 1–47
  40. Young DA, Waldo M, Rutledge JH, Freedman R. Heritability of inhibitory gating of the P50 auditory-evoked potential in monozygotic and dizygotic twins. Neuropsychobiology. 1996;33(3):113–117

PII: S0920-9964(06)00359-8

doi: 10.1016/j.schres.2006.08.009

Schizophrenia Research
Volume 89, Issue 1 , Pages 312-319 , January 2007