Schizophrenia Research
Volume 86, Issue 1 , Pages 89-98 , September 2006

Early stage vision in schizophrenia and schizotypal personality disorder

  • Brian F. O'Donnell

      Affiliations

    • Department of Psychology, Indiana University, Bloomington, IN, United States
    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States
    • Corresponding Author InformationCorresponding author. Department of Psychology, Indiana University, Bloomington, IN, United States. Tel.: +1 812 856 4164; fax: +1 812 855 4691.
    • ,
  • Andrew Bismark

      Affiliations

    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States
    • ,
  • William P. Hetrick

      Affiliations

    • Department of Psychology, Indiana University, Bloomington, IN, United States
    • ,
  • Misty Bodkins

      Affiliations

    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States
    • ,
  • Jenifer L. Vohs

      Affiliations

    • Department of Psychology, Indiana University, Bloomington, IN, United States
    • ,
  • Anantha Shekhar

      Affiliations

    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States

Received 23 December 2005 ,Revised 12 May 2006 ,Accepted 17 May 2006.

References 

  1. Bodis-Wollner I, Tagliati M. The visual system in Parkinson's disease. Adv. Neurol. 1993;60:390–394
  2. Braus DF, Weber-Fahr W, Tost H, Ruf M, Henn FA. Sensory information processing in neuroleptic-naive first-episode schizophrenic patients: a functional magnetic resonance imaging study. Arch. Gen. Psychiatry. 2002;59:696–701
  3. Brenner CA, Lysaker PH, Wilt MA, O'Donnell BF. Visual processing and neuropsychological function in schizophrenia and schizoaffective disorder. Psychiatry Res. 2002;111:125–136
  4. Brenner CA, Wilt MA, Lysaker PH, O'Donnell BF. Psychometrically matched tasks of discrimination and recognition performance in schizophrenia spectrum disorders. J. Abnorm. Psychology. 2003;112:28–37
  5. Bunney WE, Hetrick WP, Bunney BG, Patterson JV, Jin Y, Potkin SG, et al. Structured interview for assessing perceptual anomalies (SIAPA). Schizophr. Bull. 1999;25:577–592
  6. Butler PD, Javitt DC. Early-stage visual processing deficits in schizophrenia. Curr. Opin. Psychiatr. 2005;18:151–157
  7. Butler PD, Zemon V, Schechter I, Saperstein AM, Hoptman MJ, Lim KO, et al. Early-stage visual processing and cortical amplification deficits in schizophrenia. Arch. Gen. Psychiatry. 2005;62:495–504
  8. Cadenhead KS, Pery W, Shafer K, Braff DL. Cognitive functions in schizotypal personality disorder. Schizophr. Res. 1999;37:123–132
  9. Camisa KM, Wilt MAB, Lysaker PH, Rae LL, Brenner CA, O'Donnell BF. Personality traits in schizophrenia and related personality disorders. Psychiatry Res. 2005;133:23–33
  10. Chapman L, Chapman J. The measurement of differential deficit. J. Psychiatr. Res. 1973;14:303–311
  11. Chapman L, Chapman J. Commentary on two articles concerning generalized and specific cognitive deficits. J. Abnorm. Psychology. 2001;110:31–39
  12. Chen Y, Palafax GP, Nakayama K, Levy DL, Matthysse S, Holzman PS. Motion perception in schizophrenia. Arch. Gen. Psychiatry. 1999;56:149–154
  13. Chen Y, Nakayama K, Levy DL, Matthysse S, Holzman PS. Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit. Proc. Natl. Acad. Sci. 1999;96:4724–4729
  14. Chen Y, Levy DL, Sheremata S, Nakayama K, Mattysse S, Holzman PS. Effects of typical, atypical, and no antipsychotic drugs on visual contrast detection in schizophrenia. Am. J. Psychiatry. 2003;160:1795–1801
  15. Chen Y, Nakayam K, Levy DL, Matthysse SW, Holzman PS. Processing of global, but not local, direction is deficient in schizophrenia processing. Schizophr. Res. 2003;61:215–227
  16. Chen Y, Bidwell LC, Holzman PS. Visual motion integration in schizophrenia patients, their first-degree relatives, and patients with bipolar disorder. Schizophr. Res. 2005;74:271–281
  17. Cutting J, Dunne F. The nature of abnormal perceptual experiences at the onset of schizophrenia. Psychopathology. 1986;19:347–352
  18. Farmer CM, O'Donnell BF, Niznikiewicz MA, Voglmaier MM, McCarley RW, Shenton ME. Visual perception and working memory in schizotypal personality disorder. Am. J. Psychiatry. 2000;57:781–786
  19. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders – Patient Edition. New York: New York State Psychiatric Institute; 1995;
  20. First MB, Gibbon M, Spitzer RL, Williams JBW, Benjamin LS. User's Guide for the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). Washington, DC: APA Press; 1997;
  21. Foxe JJ, Doniger GM, Javitt DC. Early visual processing deficits in schizophrenia: impaired P1 generation revealed by high-density electrical mapping. Neuro Report. 2001;12:3815–3820
  22. Green MF, Nuechterlein KH, Mintz J. Backward masking in schizophrenia and mania: II. Specifying the visual channels. Arch. Gen. Psychiatry. 1994;51:945–951
  23. Hooker C, Park S. Trajectory estimation in schizophrenia. Schizophr. Res. 2000;45:83–92
  24. Kay SR, Abraham F, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr. Bull. 1987;13:261–275
  25. Kéri S, Antal A, Szekeres G, Benedek G, Janka Z. Spatiotemporal visual processing in schizophrenia. J. Neuropsychiatry Clin. Neurosci. 2002;14:190–196
  26. Kéri S, Kelemen O, Benedek G, Janka Z. Vernier threshold in patients with schizophrenia and in their unaffected siblings. Neuropsychology. 2004;18:537–542
  27. Kety SS, Wender PH, Jacobsen F, Ingraham LJ, Jansson L, Faber B, et al. Mental Illness in the biological and adoptive relatives of schizophrenic adoptees: replication of the Copenhagen study in the rest of Denmark. Arch. Gen. Psychiatry. 1994;51:442–455
  28. Krishnan GP, Vohs JL, Carroll CA, Hetrick WP, Shekhar A, Bockbrader MA, et al. Steady state visual evoked potential abnormalities in schizophrenia. Clin. Neurophysiol. 2005;116:614–624
  29. Lafargue T, Brasic J. Neurodevelopmental hypothesis of schizophrenia: a central sensory disturbance. Med. Hypotheses. 2000;55:314–318
  30. Legge G. Sustained and transient mechanisms in human vision: temporal and spatial properties. Vis. Res. 1978;18:69–81
  31. Levitt H. Transformed up-down methods in psychoacoustics. J. Acoust. Soc. Am. 1970;49:467–477
  32. Lezak MD. Neuropsychological Assessment. 3rd ed.. New York: Oxford University Press; 1995;
  33. Li C-SR. Impaired detection of visual motion in schizophrenia patients. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 2002;26:929–934
  34. Livingstone M, Hubel D. Segregation of form, color, movement and depth: anatomy, physiology and perception. Science. 1988;240:740–749
  35. Merigan WH, Maunsell JHR. How parallel are the primate visual pathways?. Annu. Rev. Neurosci. 1993;16:369–402
  36. Merigan W, Freeman A, Meyers SP. Parallel processing streams in the human visual cortex. NeuroReport. 1997;18:3881–3985
  37. Mohamed S, Paulsen JS, O'Leary D, Arndt S, Andreasen N. Generalized cognitive deficits in schizophrenia: a study of first-episode patients. Arch. Gen. Psychiatry. 1999;56:749–754
  38. Newsome WT, Pare EB. A selective impairment of motion perception following lesions of the middle temporal visual area (MT). J. Neurosci. 1988;8:2201–2211
  39. O'Donnell BF, Swearer JM, Smith LT, Nestor PG, Shenton ME, McCarley RW. Selective deficits in visual perception and recognition in schizophrenia. Am. J. Psychiatry. 1996;153:687–692
  40. Onitsuka T, Shenton ME, Kasai K, Nestor PG, Toner SK, Kikinis R, et al. Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia. Arch. Gen. Psychiatry. 2003;60:349–359
  41. Onitsuka T, Shenton ME, Salisbury DF, Dickey CC, Kasai K, Toner SK, et al. Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study. Am. J. Psychiatry. 2004;16:1603–1611
  42. Phillipson OT, Harris JP. Perceptual changes in schizophrenia: a questionnaire survey. Psychol. Med. 1985;15:859–866
  43. Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr. Bull. 1991;17:555–564
  44. Raine A, Reynolds C, Lencz T, Scerbo A, Triphon N, Kim D. Cognitive–perceptual, interpersonal, and disorganized features of schizotypal personality. Schizophr. Bull. 1994;20:191–201
  45. Renshaw PF, Yurglen-Todd DA, Cohen BM. Greater hemodynamic response to photic stimulation in schizophrenic patients: and echo planar MRI study. Am. J. Psychiatry. 1994;151:1493–1495
  46. Richardson AJ, Gruzlier JH, Puri BK. Reduced visual motion sensitivity in unmedicated schizophrenic patients. Eur. Psychiatr. 1996;11:422S
  47. Schwartz BD, McGinn T, Winstead DK. Disordered spatiotemporal processing in schizophrenics. Biol. Psychiatry. 1987;22:688–698
  48. Selemon LD, Rajkowska G, Goldman-Rakic PS. Abnormally high neuronal density in the schizophrenic cortex. Arch. Gen. Psychiatry. 1995;52:805–818
  49. Sheehan DV, Lecrubier Y, Harnett-Sheehan K, Amorim P, Janavs J, Weiller E, et al. The Mini International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview. J. Clin. Psychiatry. 1998;59:22–33
  50. Siever LJ, Davis KL. The pathophysiology of schizophrenia disorders: perspectives from the spectrum. Am. J. Psychiatry. 2004;161:398–413
  51. Slaghuis WL. Contrast sensitivity for stationary and drifting spatial frequency gratings in positive- and negative-symptom schizophrenia. J. Abnorm. Psychology. 1998;107(1):49–62
  52. Slaghuis WL. Spatio-temporal luminance contrast sensitivity and visual backward making in schizophrenia. Exp. Brain Res. 2004;156:196–211
  53. Stuve TA, Friedman L, Jesberger JA, Gilmore GC, Strauss ME, Meltzer HY. The relationship between smooth pursuit performance, motion perception and sustained visual attention in patients with schizophrenia and normal controls. Psychol. Med. 1997;27:143–152
  54. Tagliati M, Bodis-Wollner I, Kovanecz I, Stanzione P. Spatial frequency tuning of the monkey pattern ERG depends on D2 receptor-linked action of dopamine. Vis. Res. 1994;34:2051–2057
  55. Taylor SF, Tandon R, Koeppe RA. PET study of greater visual activation in schizophrenia. Am. J. Psychiatry. 1997;154:1296–1298
  56. Tyler CW. Analysis of normal flicker sensitivity and its variability in the visuogram test. Investig. Ophthalmol. Vis. Sci. 1991;32:2552–2560
  57. Tyler CW, McBride B. The morphonome image psychophysics software and calibrator for Macintosh Systems. Spat. Vis. 1995;10:479–484
  58. Ungerleider LG. The corticocortical pathways for object recognition and spatial perception. In:  Chagas C,  Gattass R,  Gross C editor. Pattern Recognition Mechanisms. Berlin: Springer; 1985;p. 21–37
  59. Van Essen DC, Gallant JL. Neural mechanisms of form and motion processing in the primate visual system. Neuron. 1994;13:1–10
  60. Wandell BA. Foundations of Vision. Sunderland, MA: Sinauer; 1995;
  61. Wechsler D. WAIS-III. Administration and Scoring Manual. San Antonio, TX: Psychological Corporation; 1997;

PII: S0920-9964(06)00241-6

doi: 10.1016/j.schres.2006.05.016

Schizophrenia Research
Volume 86, Issue 1 , Pages 89-98 , September 2006

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