Genetic analysis of the human ENTH (Epsin 4) gene and schizophrenia

Liou, Ying-Jay; Lai, I-Ching; Wang, Ying-Chieh; Bai, Ya-Mei; Lin, Chao-Cheng; Lin, Chih-Yuan; Chen, Tzu-Ting; Chen, Jen-Yeu

doi:10.1016/j.schres.2006.02.021

« Previous Next »Schizophrenia Research
Volume 84, Issue 2 , Pages 236-243, June 2006

Genetic analysis of the human ENTH (Epsin 4) gene and schizophrenia

Ying-Jay Liou
- Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
- Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Miaoli, Taiwan
I-Ching Lai
- Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
- Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Miaoli, Taiwan
- Institute of Medical Science, Tzu Chi University, Hualien, Taiwan
Ying-Chieh Wang
- Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
- Institute of Medical Science, Tzu Chi University, Hualien, Taiwan
Ya-Mei Bai
- Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
- Institute of Public Health, National Yang-Ming University, Taipei, Taiwan
Chao-Cheng Lin
- Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
- Institute of Medical Science, College of Medicine, Taipei Medical University, Taipei, Taiwan
Chih-Yuan Lin
- Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
Tzu-Ting Chen
- Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
- Graduate Institute of Behavior Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
Jen-Yeu Chen
- Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
- Corresponding author. Department of Psychiatry, Yuli Veterans Hospital, Yuli, Hualien 981, Taiwan. Tel.: +886 3 8883141x312, 645; fax: +886 3 8887091.

Received 10 November 2005; received in revised form 25 February 2006; accepted 26 February 2006.

Abstract

Numerous linkage studies suggest that chromosome 5q may be one of the important cytogenetic regions containing risk loci for schizophrenia susceptibility. Recently, genetic variations (rs254664 and rs10046055) in the intron 1 and 5′ flanking regions of the ENTH (also known as Epsin 4) gene, which is located in 5q 33.3, have been demonstrated to be significantly associated with schizophrenia. The present study investigates whether this finding could be replicated in a population of Han Chinese, consisting of 269 patients with schizophrenia and 236 normal controls, by analyzing 9 single nucleotide polymorphisms (SNPs) ranging from the 5′ upstream region to intron 8 of the ENTH gene and covering 96kb. The results showed that we failed to identify the associations of rs1186922 and rs10046055 with schizophrenia. Although another genetic variation (rs1186922) showed a weak association with schizophrenia (uncorrected p value for alleles=0.038), the significance did not survive after Bonferroni correction. This study thus fails to support an association of genetic variations in the ENTH gene and schizophrenia.