Schizophrenia Research
Volume 80, Issue 2 , Pages 137-149 , 15 December 2005

Cognitive functioning in patients with schizophrenia and bipolar disorder: A quantitative review

  • Lydia Krabbendam

      Affiliations

    • Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO BOX 616 (KAP2), 6200 MD Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 43 3882582; fax: +31 43 3882578.
    • ,
  • Baer Arts

      Affiliations

    • Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO BOX 616 (KAP2), 6200 MD Maastricht, The Netherlands
    • ,
  • Jim van Os

      Affiliations

    • Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO BOX 616 (KAP2), 6200 MD Maastricht, The Netherlands
    • Division of Psychological Medicine, Institute of Psychiatry, London, UK
    • ,
  • André Aleman

      Affiliations

    • BCN NeuroImaging Center, University of Groningen, Groningen, The Netherlands

Received 15 June 2005 ,Revised 9 August 2005 ,Accepted 9 August 2005.

References 

  1. Addington J, Addington D. Facial affect recognition and information processing in schizophrenia and bipolar disorder. Schizophr. Res. 1998;32:171–181
  2. Albus M, Hubmann W, Wahlheim C, Sobizack N, Franz U, Mohr F. Contrasts in neuropsychological test profile between patients with first-episode schizophrenia and first-episode affective disorders. Acta Psychiatr. Scand. 1996;94:87–93
  3. Aleman A, Hijman R, De Haan EHF, Kahn RS. Memory impairment in schizophrenia: a meta-analysis. Am. J. Psychiatry. 1999;156:1358–1366
  4. Altshuler LL, Ventura J, van Gorp WG, Green MF, Theberge DC, Mintz J. Neurocognitive function in clinically stable men with bipolar I disorder or schizophrenia and normal control subjects. Biol. Psychiatry. 2004;56:560–569
  5. Arduini L, Kalyvoka A, Stratta P, Rinaldi O, Daneluzzo E, Rossi A. Insight and neuropsychological function in patients with schizophrenia and bipolar disorder with psychotic features. Can. J. Psychiatry. 2003;48:338–341
  6. Asarnow RF. Neurocognitive impairments in schizophrenia: a piece of the epigenetic puzzle. Eur. Child Adolesc. Psychiatry. 1999;8:I5–I8
  7. Baumann B, Bogerts B. The pathomorphology of schizophrenia and mood disorders: similarities and differences. Schizophr. Res. 1999;39:141–148(discussion 162)
  8. Bramon E, Sham PC. The common genetic liability between schizophrenia and bipolar disorder: a review. Curr. Psychiatry Rep. 2001;3:332–337
  9. Brockington IF, Kendell RE, Wainwright S, Hillier VF, Walker J. The distinction between the affective psychoses and schizophrenia. Br. J. Psychiatry. 1979;135:243–248
  10. Brockington IF, Kendell RE, Wainwright S. Depressed patients with schizophrenic or paranoid symptoms. Psychol. Med. 1980;10:665–675
  11. Cardno AG, Rijsdijk FV, Sham PC, Murray RM, McGuffin P. A twin study of genetic relationships between psychotic symptoms. Am. J. Psychiatry. 2002;159:539–545
  12. Chua SE, Murray RM. The neurodevelopmental theory of schizophrenia: evidence concerning structure and neuropsychology. Ann. Med. 1996;28:547–555
  13. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ: Erlbaum; 1988;
  14. Crow TJ. From Kraepelin to Kretschmer leavened by Schneider: the xtransition from categories of psychosis to dimensions of variation intrinsic to homo sapiens. Arch. Gen. Psychiatry. 1998;55:502–504
  15. Cuesta MJ, Peralta V, Caro F, de Leon J. Schizophrenic syndrome and Wisconsin Card Sorting Test dimensions. Psychiatry Res. 1995;58:45–51
  16. Dalby JT, Williams R. Preserved reading and spelling ability in psychotic disorders. Psychol. Med. 1986;16:171–175
  17. Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test: Adult Version. San Antonio, TX: The Psychological Corporation; 1987;
  18. Dickerson FB, Sommerville J, Origoni AE, Ringel NB, Parente F. Outpatients with schizophrenia and bipolar I disorder: do they differ in their cognitive and social functioning?. Psychiatry Res. 2001;102:21–27
  19. Docherty NM, DeRosa M, Andreasen NC. Communication disturbances in schizophrenia and mania. Arch. Gen. Psychiatry. 1996;53:358–364
  20. Gard D, Harrell EH, Poreh A. Cognitive deficits in schizophrenia on the WAIS-R NI Sentence Arrangement Subtest. Wechsler Adult Intelligence Scale-Revised Neuropsychological Inventory. J. Clin. Psychol. 1999;55:1085–1094
  21. Gold JM, Carpenter C, Randolph C, Goldberg TE, Weinberger DR. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch. Gen. Psychiatry. 1997;54:159–165
  22. Gold JM, Queern C, Iannone VN, Buchanan RW. Repeatable battery for the assessment of neuropsychological status as a screening test in schizophrenia: I. Sensitivity, reliability, and validity. Am. J. Psychiatry. 1999;156:1944–1950
  23. Goldberg TE. Some fairly obvious distinctions between schizophrenia and bipolar disorder. Schizophr. Res. 1999;39:127–132
  24. Goldberg TE, Gold JM, Greenberg R, Griffin S, Schulz SC, Pickar D, et al. Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery. Am. J. Psychiatry. 1993;150:1355–1362
  25. Green MF, Nuechterlein KH, Mintz J. Backward masking in schizophrenia and mania: I. Specifying a mechanism. Arch. Gen. Psychiatry. 1994;51:939–944
  26. Gruzelier J, Seymour K, Wilson L, Jolley A, Hirsch S. Impairments on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Arch. Gen. Psychiatry. 1988;45:623–629
  27. Hawkins KA, Hoffman RE, Quinlan DM, Rakfeldt J, Docherty NM, Sledge WH. Cognition, negative symptoms, and diagnosis: a comparison of schizophrenic, bipolar, and control samples. J. Neuropsychiatry Clin. Neurosci. 1997;9:81–89
  28. Heaton RK. A Manual for the Wisconsin Card Sorting Test. Odessa: Psychological Assessment Resources; 1981;
  29. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12:426–445
  30. Hobart MP, Goldberg R, Bartko JJ, Gold JM. Repeatable battery for the assessment of neuropsychological status as a screening test in schizophrenia, II: convergent/discriminant validity and diagnostic group comparisons. Am. J. Psychiatry. 1999;156:1951–1957
  31. Hoff AL, Shukla S, Aronson T, Cook B, Ollo C, Baruch S, et al. Failure to differentiate bipolar disorder from schizophrenia on measures of neuropsychological function. Schizophr. Res. 1990;3:253–260
  32. Jablensky A. The conflict of the nosologists: views on schizophrenia and manic-depressive illness in the early part of the 20th century. Schizophr. Res. 1999;39:95–100(discussion 159)
  33. Jones PB, Tarrant CJ. Specificity of developmental precursors to schizophrenia and affective disorders. Schizophr. Res. 1999;39:121–125(discussion 161)
  34. Kessels RP, Aleman A, Verhagen WI, van Luijtelaar EL. Cognitive functioning after whiplash injury: a meta-analysis. J. Int. Neuropsychol. Soc. 2000;6:271–278
  35. Koren D, Seidman LJ, Harrison RH, Lyons MJ, Kremen WS, Caplan B, et al. Factor structure of the Wisconsin card sorting test: dimensions of deficit in schizophrenia. Neuropsychology. 1998;12:289–302
  36. Krabbendam L, Honig A, Wiersma J, Vuurman EF, Hofman PA, Derix MM, et al. Cognitive dysfunctions and white matter lesions in patients with bipolar disorder in remission. Acta Psychiatr.Scand. 2000;101:274–280
  37. Kraepelin E. Dementia praecox and paraphrenia. Livingstone, Livingstone. 1913;
  38. Kremen WS, Seidman LJ, Faraone SV, Tsuang MT. Is there disproportionate impairment in semantic or phonemic fluency in schizophrenia?. J. Int. Neuropsychol. Soc. 2003;9:79–88
  39. Lipsey MW, Wilson DB. Practical Meta-analysis. Thousand Oaks, CA: Sage; 2001;
  40. Luteijn F, van der Ploeg FAE. Handleiding Groninger Intelligentietest (GIT) ([Manual Groningen Intelligence Test]), Lisse, The Netherlands: Swets and Zeitlinger; 1983;
  41. Maier W, Lichtermann D, Franke P, Heun R, Falkai P, Rietschel M. The dichotomy of schizophrenia and affective disorders in extended pedigrees. Schizophr. Res. 2002;57:259–266
  42. Marneros A. The schizoaffective phenomenon: the state of the art. Acta Psychiatr. Scand. 2003;418:29–33(Suppl)
  43. Martinez-Aran A, Vieta E, Colom F, Reinares M, Benabarre A, Gasto C, et al. Cognitive dysfunctions in bipolar disorder: evidence of neuropsychological disturbances. Psychother. Psychosom. 2000;69:2–18
  44. Martinez-Aran A, Penades R, Vieta E, Colom F, Reinares M, Benabarre A, et al. Executive function in patients with remitted bipolar disorder and schizophrenia and its relationship with functional outcome. Psychother. Psychosom. 2002;71:39–46
  45. Martinez-Aran A, Vieta E, Reinares M, Colom F, Torrent C, Sanchez-Moreno J, et al. Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. Am. J. Psychiatry. 2004;161:262–270
  46. McGrath J, Scheldt S, Welham J, Clair A. Performance on tests sensitive to impaired executive ability in schizophrenia, mania and well controls: acute and subacute phases. Schizophr. Res. 1997;26:127–137
  47. Mojtabai R, Bromet EJ, Harvey PD, Carlson GA, Craig TJ, Fennig S. Neuropsychological differences between first-admission schizophrenia and psychotic affective disorders. Am. J. Psychiatry. 2000;157:1453–1460
  48. Morice R. Cognitive inflexibility and pre-frontal dysfunction in schizophrenia and mania. Br. J. Psychiatry. 1990;15750–15754
  49. Murray RM, Sham P, Van Os J, Zanelli J, Cannon M, McDonald C. A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophr. Res. 2004;71:405–416
  50. Park S. Association of an oculomotor delayed response task and the Wisconsin card sort test in schizophrenic patients. Int. J. Psychophysiol. 1997;27:147–151
  51. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Arch. Gen. Psychiatry. 1992;49:975–982
  52. Quraishi S, Frangou S. Neuropsychology of bipolar disorder: a review. J. Affect. Disord. 2002;72:209–226
  53. Reitan RM. Validity of the Trail Making Test as an indication of organic brain damage. Percept. Mot. Skills. 1958;8:271–276
  54. Rey A. L'examen psychologique dans les cas d'encephalopathie traumatique: les problèmes ([The psychological examination in cases of traumatic encephalopathy: problems]), Archives de Psychologie. 1941;28:215–285
  55. Rey A. L'examen Clinique en Psychologie ([Clinical Assessment in Psychology]), Paris: Presses Universitaires de France; 1964;
  56. Rosenthal R. Meta-analytic Procedures for Social Research. London: Sage Publications; 1991;
  57. Rossi A, Arduini L, Daneluzzo E, Bustini M, Prosperini P, Stratta P. Cognitive function in euthymic bipolar patients, stabilized schizophrenic patients, and healthy controls. J. Psychiatr. Res. 2000;34:333–339
  58. Seidman LJ, Kremen WS, Koren D, Faraone SV, Goldstein JM, Tsuang MT. A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophr. Res. 2002;53:31–44
  59. Seidman LJ, Lanca M, Kremen WS, Faraone SV, Tsuang MT. Organizational and visual memory deficits in schizophrenia and bipolar psychoses using the Rey–Osterrieth complex figure: effects of duration of illness. J. Clin. Exp. Neuropsychol. 2003;25:949–964
  60. Shaddish WR, Haddock CK. Combining estimates of effect size. In:  Cooper H,  Hedges V editor. The Handbook of Research Synthesis. New York: Sage Publications; 1994;p. 261–285
  61. Signoret JL. BEM-84, Batterie d'efficience Mnésique Réduite ([Abbreviated Battery of Memory Efficiency]), Paris: Editions Elsevier; 1991;
  62. Silverstein ML, McDonald C, Fogg L. Intelligence and neuropsychological functioning in psychiatric disorders. Arch. Clin. Neuropsychol. 1990;5:317–323
  63. Siris SG. Depression in schizophrenia: perspective in the era of “atypical” antipsychotic agents. Am. J. Psychiatry. 2000;157:1379–1389
  64. Stroop JR. Studies of interference in serial verbal reactions. J. Exp. Psychol. 1935;18:643–662
  65. Tabares Seisdedos R, Balanza Martinez V, Salazar Fraile J, Selva Vera G, Leal Cercos C, Gomez Beneyto M. Specific executive/attentional deficits in patients with schizophrenia or bipolar disorder who have a positive family history of psychosis. J. Psychiatr. Res. 2003;37:479–486
  66. Tam WC, Liu Z. Comparison of neurocognition between drug-free patients with schizophrenia and bipolar disorder. J. of Nerv. Ment. Dis. 2004;192:464–470
  67. Tam WC, Sewell KW, Deng HC. Information processing in schizophrenia and bipolar disorder: a discriminant analysis. J. of Nerv. Ment. Dis. 1998;186:597–603
  68. Thomas P, Kearney G, Napier E, Ellis E, Leuder I, Johnson M. Speech and language in first onset psychosis differences between people with schizophrenia, mania, and controls. Br. J. Psychiatry. 1996;168:337–343
  69. Tien AY, Eaton WW. Psychopathologic precursors and sociodemographic risk factors for the schizophrenia syndrome. Arch. Gen. Psychiatry. 1992;49:37–46
  70. Tien AY, Ross DE, Pearlson G, Strauss ME. Eye movements and psychopathology in schizophrenia and bipolar disorder. J. of Nerv. Ment. Dis. 1996;184:331–338
  71. Van Gorp WG, Altshuler L, Theberge DC, Wilkins J, Dixon W. Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study. Arch. Gen. Psychiatry. 1998;55:41–46
  72. Van Os J, Jones P, Lewis G, Wadsworth M, Murray R. Developmental precursors of affective illness in a general population birth cohort. Arch. Gen. Psychiatry. 1997;54:625–631
  73. Van Os J, Jones P, Sham P, Bebbington P, Murray RM. Risk factors for onset and persistence of psychosis. Soc. Psychiatry Psychiatr. Epidemiol. 1998;33:596–605
  74. Verdoux H, Liraud F. Neuropsychological function in subjects with psychotic and affective disorders. Relationship to diagnostic category and duration of illness. Eur. Psychiatry. 2000;15:236–243
  75. Wechsler D. Wechsler Adult Intelligence Scale. Manual. New York: Psychological Corporation; 1955;
  76. Wechsler D. Wechsler Adult Intelligence Scale-Revised. New York: Psychological Corporation; 1981;
  77. Wechsler D. Wechsler Memory Scale-Revised Manual. New York: The Psychological Corporation; 1987;
  78. Wechsler D. WAIS-III: Wechsler Adult Intelligence Scale. Administration and Scoring Manual. 3rd ed.. New York: Psychological Corporation; 1997;
  79. Wildenauer DB, Schwab SG, Maier W, Detera-Wadleigh SD. Do schizophrenia and affective disorder share susceptibility genes?. Schizophr. Res. 1999;39:107–111(discussion 160)
  80. Young DA, Zakzanis KK, Bailey C, Davila R, Griese J, Sartory G, et al. Further parameters of insight and neuropsychological deficit in schizophrenia and other chronic mental disease. J. of Nerv. Ment. Dis. 1998;186:44–50
  81. Zakzanis KK, Leach L, Kaplan E. Neuropsychological Differential Diagnosis. Lisse, The Netherlands: Swets and Zeitlinger; 1999;
  82. Zalla T, Joyce C, Szoke A, Schurhoff F, Pillon B, Komano O, et al. Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia. Psychiatry Res. 2004;121:207–217

PII: S0920-9964(05)00360-9

doi: 10.1016/j.schres.2005.08.004

Schizophrenia Research
Volume 80, Issue 2 , Pages 137-149 , 15 December 2005

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