Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia

Kirihara, Kenji; Araki, Tsuyoshi; Kasai, Kiyoto; Maeda, Keiko; Hata, Akinobu; Uetsuki, Miki; Yamasue, Hidenori; Rogers, Mark A.; Kato, Nobumasa; Iwanami, Akira

doi:10.1016/j.schres.2005.08.003

« Previous Next »Schizophrenia Research
Volume 80, Issue 2 , Pages 197-201, 15 December 2005

Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia

Kenji Kirihara
- Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan
- Corresponding authors. Kirihara is to be contacted at Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan. Tel.: +81 3 5800 9263; fax: +81 3 5800 6894.
Tsuyoshi Araki
- Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan
Kiyoto Kasai
- Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan
- Corresponding authors. Kirihara is to be contacted at Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan. Tel.: +81 3 5800 9263; fax: +81 3 5800 6894.
Keiko Maeda
- Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan
Akinobu Hata
- Fukushima Prefectural Mental Health and Welfare Centre, 8-30 Oyamacho, Fukushimashi, Fukushima 960-8012, Japan
Miki Uetsuki
- Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan
Hidenori Yamasue
- Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan
Mark A. Rogers
- Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan
- Department of Psychology, Monash University, Clayton 3168, Vicotoria, Australia
Nobumasa Kato
- Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan
Akira Iwanami
- Department of Medical Technology, Aino University, 4-5-4 Higashiohta, Ibaraki, Osaka 567-0012, Japan

Received 14 May 2005; received in revised form 3 August 2005; accepted 3 August 2005.

Abstract

We have previously reported an association between reduced amplitude of auditory P300 event-related potential and severity of positive thought disorder as assessed by the Comprehensive Index of Positive Thought Disorder in a sample of patients with chronic schizophrenia. Here we replicate those findings using a different measure, Thought Disorder Index (TDI), in a new larger sample of 55 patients. The auditory P300 amplitude showed a significant negative correlation with scores on TDI. This correlation was relatively more pronounced in the left temporal region than in the right temporal region. These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia.

Keywords: Schizophrenia, P300, Event-related potentials, Thought disorder