Schizophrenia Research
Volume 80, Issue 2 , Pages 235-242 , 15 December 2005

Schizotypal dimensions: Continuity between schizophrenia and bipolar disorders

  • Franck Schürhoff

      Affiliations

    • Département hospitalo-universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor (AP-HP), 40 rue Mesly, 94000 Créteil, France
    • Unité INSERM U 513, “Neurobiologie et Psychiatrie”, Hôpital Henri Mondor, 94000 Créteil, France
    • Corresponding Author InformationCorresponding author. Département hospitalo-universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor (AP-HP), 40 rue Mesly, 94000 Créteil, France. Tel.: +33 1 49 81 30 51; fax: +33 1 49 81 30 59.
    • ,
  • Audrey Laguerre

      Affiliations

    • Département hospitalo-universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor (AP-HP), 40 rue Mesly, 94000 Créteil, France
    • Unité INSERM U 513, “Neurobiologie et Psychiatrie”, Hôpital Henri Mondor, 94000 Créteil, France
    • ,
  • Andreï Szöke

      Affiliations

    • Département hospitalo-universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor (AP-HP), 40 rue Mesly, 94000 Créteil, France
    • Unité INSERM U 513, “Neurobiologie et Psychiatrie”, Hôpital Henri Mondor, 94000 Créteil, France
    • ,
  • Alexandre Méary

      Affiliations

    • Département hospitalo-universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor (AP-HP), 40 rue Mesly, 94000 Créteil, France
    • Unité INSERM U 513, “Neurobiologie et Psychiatrie”, Hôpital Henri Mondor, 94000 Créteil, France
    • Service de Pharmacologie Clinique, Hôpital Henri Mondor, 94000 Créteil, France
    • ,
  • Marion Leboyer

      Affiliations

    • Département hospitalo-universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor (AP-HP), 40 rue Mesly, 94000 Créteil, France
    • Unité INSERM U 513, “Neurobiologie et Psychiatrie”, Hôpital Henri Mondor, 94000 Créteil, France

Received 21 March 2005 ,Revised 22 July 2005 ,Accepted 23 July 2005.

References 

  1. Andreasen NC, Carpenter WT. Diagnosis and classification of schizophrenia. Schizophr. Bull. 1993;19:199–214
  2. Andreasen NC, Olsen S. Negative versus positive schizophrenia: definition and validation. Arch. Gen. Psychiatry. 1982;39:789–794
  3. Arndt S, Alliger RJ, Andreasen NC. The distinction of positive and negative symptoms. The failure of a two-dimensional model. Br. J. Psychiatry. 1991;158:317–322
  4. Battaglia M, Cavallini MC, Macciardi F, Bellodi F. The structure of the DSM-III-R schizotypal personality disorder diagnosed by direct interviews. Schizophr. Bull. 1997;23:83–92
  5. Baron M, Gruen RS, Romo-Gruen JM. Positive and negative symptoms. Relation to familial transmission of schizophrenia. Br. J. Psychiatry. 1992;161:610–614
  6. Bilder RM, Mukherjee S, Rieder RO, Pandurangi AK. Symptomatic and neuropsychological components of defect states. Schizophr. Bull. 1985;11:409–419
  7. Bleuler E. Dementia Praecox of the Group of Schizophrenias (Translated by J. Zinkin). New York, NY: International Universities Press; 1911/1950;
  8. Bramon E, Sham PC. The common genetic liability between schizophrenia and bipolar disorder: a review. Curr. Psychiatry Rep. 2001;3:332–337
  9. Burke JG, Murphy BM, Bray JC, Walsh D, Kendler KS. Clinical similarities in siblings with schizophrenia. Am. J. Med. Genet. (Part B). 1996;67:239–243
  10. Cardno AG, Holmans PA, Harvey I, Williams MB, Owen MJ, McGuffin P. Factor-derived subsyndromes of schizophrenia and familial morbid risks. Schizophr. Res. 1997;23:231–238
  11. Cardno AG, Sham PC, Murray RM, McGuffin P. Twin study of symptom dimensions in psychosis. Br. J. Psychiatry. 2001;179:39–45
  12. Coryell WH, Zimmerman M. Personality disorder in the families of depressed, schizophrenic, and never-ill probands. Am. J. Psychiatry. 1989;146:496–502
  13. Crow TJ. Positive and negative schizophrenia symptoms and the role of dopamine. Br. J. Psychiatry. 1981;139:251–254
  14. Crow TJ. Psychotic continuum or disease entities? The critical impact of nosology on the problem of aetiology. In:  Marneros A,  Andreasen NC,  Tsuang MT editor. Psychotic Continuum. Berlin: Springer; 1995;p. 151–163
  15. Dumas P, Bouafia S, Gutknecht C, Saoud M, Dalery J, d'Amato T. Validation of the French version of the raine schizotypal personality disorder questionnaire — categorical and dimensional approach to schizotypal personality traits in a normal student population. Encephale. 2000;26:42–46
  16. Dworkin RH, Lenzenweger MF. Symptoms and the genetics of schizophrenia: implications for diagnosis. Am. J. Psychiatry. 1984;141:1541–1546
  17. Etain, B., Roy, I., Henry, C., Schürhoff, F., Rousseva, A., Leboyer, M., Bellivier, F., Physical anhedonia is not a candidate symptom nor an endophenotype in bipolar disorders. (submitted for publication).
  18. Fischer RA. Statistical Methods for Research Workers. Edinburgh: Oliver and Boyd Eds; 1925;
  19. Gruzelier JH. The factorial structure of schizotypy, part I: affinities with syndromes of schizophrenia. Schizophr. Bull. 1996;22:611–620
  20. Guerra A, Fearon P, Sham P, Jones P, Lewis S, Mata I, et al. The relationship between predisposing factors, premorbid function and symptom dimensions in psychosis: an integrated approach. Eur. Psychiatr. 2002;17:311–320
  21. Hull JW, Smith TE, Anthony DE, Goodman MS, Kentros MK, Sepe O, et al. Patterns of symptom change: a longitudinal analysis. Schizophr. Res. 1997;24:17–18
  22. Kendler KS, McGuire M, Gruenberg AM, Walsh D. Clinical heterogeneity in schizophrenia and the pattern of psychopathology in relatives: results from an epidemiologically based family study. Acta Psychiatr. Scand. 1994;89:294–300
  23. Kendler KS, McGuire M, Gruenberg AM, Walsh D. Outcome and family study of the subtypes of schizophrenia in the west of Ireland. Am. J. Psychiatry. 1994;151:849–856
  24. Kendler KS, McGuire M, Gruenberg AM, Walsh D. Schizotypal symptoms and signs in the roscommon family study: their factor structure and familial relationship with psychotic and affective disorders. Arch. Gen. Psychiatry. 1995;52:296–303
  25. Kendler KS, Karkowski-Shuman L, O'Neill A, Straub RE, MacLean CJ, Walsh D. Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish study of high-density schizophrenia families: evidence for possible etiologic heterogeneity. Am. J. Psychiatry. 1997;154:191–198
  26. Kety SS, Wender PH, Jacobsen B, Ingraham LJ, Jansson L, Faber B, et al. Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen Study in the rest of Denmark. Arch. Gen. Psychiatry. 1994;51:442–455
  27. Liddle PF, Barnes TR. Syndromes of chronic schizophrenia. Br. J. Psychiatry. 1990;157:558–561
  28. Loftus J, DeLisi LE, Crow TJ. Familial associations of subsyndromes of psychosis in affected sibling pairs with schizophrenia and schizoaffective disorders. Psychiatry Res. 1998;80:101–111
  29. McGuffin P, Farmer AE, Harvey I. A polydiagnostic application of operational criteria in psychotic illness: development and reliability of the OPCRIT system. Arch. Gen. Psychiatry. 1991;48:50–55
  30. Maxwell ME. Family Interview for Genetic Studies. Clinical Neurogenetic Branch, Intramural Research Program, NIMH, USA. 1992;
  31. Nurnberger JI, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, et al. Diagnostic interview for genetic studies. Rationale, unique features, and training, NIMH genetics initiative. Arch. Gen. Psychiatry. 1994;51:849–859
  32. Preisig M, Fenton BT, Matthey ML, Berney A, Ferrero F. Diagnostic interview for genetic studies (DIGS): inter-rater and test–retest reliability of the French version. Eur. Arch. Psychiatry Clin. Neurosci. 1999;249:174–179
  33. Rabe-Hesketh S, Toulopoulou T, Murray R. Multilevel modelling of cognitive function in schizophrenic patients and their first degree relatives. Multivar. Behav. Res. 2001;36:279–298
  34. Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr. Bull. 1991;17:555–564
  35. Raine A, Reynolds C, Lencz T, Scerbo A, Triphon N, Kim D. Cognitive–perceptual, interpersonal, and disorganized features of schizotypal personality. Schizophr. Bull. 1994;20:191–201
  36. Reynolds CA, Raine A, Mellingen K, Venables PH, Mednick SA. Three-factor model of schizotypal personality: invariance across culture, gender, religious affiliation, family adversity, and psychopathology. Schizophr. Bull. 2000;26:603–618
  37. Rossi A, Daneluzzo E. Schizotypal dimensions in normals and schizophrenic patients: a comparison with other clinical samples. Schizophr. Res. 2002;54:67–75
  38. Schürhoff F, Szöke A, Bellivier F, Turcas C, Villemur M, Tignol J, et al. Anhedonia in schizophrenia: a distinct familial subtypes?. Schizophr. Res. 2003;61:59–66
  39. Schürhoff F, Szöke A, Méary A, Bellivier F, Rouillon F, Pauls D, et al. Familial aggregation of delusional proneness in schizophrenia and bipolar pedigrees. Am. J. Psychiatry. 2003;160:1313–1319
  40. Serretti A, Mandelli L, Lattuada E, Cusin C, Smeraldi E. Clinical and demographic features of mood disorder subtypes. Psychiatry Res. 2002;112:195–210
  41. Squires-Wheeler E, Skodol AE, Friedman D, Erlenmeyer-Kimling L. The specificity of DSM-III schizotypal personality traits. Psychol. Med. 1988;18:757–765
  42. Squires-Wheeler E, Skodol AE, Basset A, Erlenmeyer-Kimling L. DSM-III-R schizotypal personality traits in offspring of schizophrenic disorder, affective disorder, and normal control parents. J. Psychiatr. Res. 1989;23:229–239
  43. Van Os J, Marcelis M, Sham P, Gilvarry K, Murray R. Psychopathological syndromes and familial morbid risk of psychosis. Br. J. Psychiatry. 1997;170:241–246
  44. Verdoux H, Van Os J, Sham P, Jones P, Gilvarry K, Murray R. Does familiality predispose to both emergence and persistence of psychosis? A follow-up study. Br. J. Psychiatry. 1996;168:620–626
  45. Vollema MG, Hoijtink H. The multidimensionality of self-report schizotypy in a psychiatric population: an analysis using multidimensional Rasch models. Schizophr. Bull. 2000;26:565–575
  46. Wickham H, Walsh C, Asherson P, Taylor C, Sigmundson T, Gill M, et al. Familiality of symptom dimensions in schizophrenia. Schizophr. Res. 2001;47:223–232
  47. Yeung AS, Lyons MS, Waternaux CM, Faraone SV, Tusang MT. A family study of self-reported personality traits and DSM-III-R personality disorders. Psychiatry Res. 1993;48:243–255

PII: S0920-9964(05)00322-1

doi: 10.1016/j.schres.2005.07.009

Schizophrenia Research
Volume 80, Issue 2 , Pages 235-242 , 15 December 2005

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